Grandem 1 Mg Injection 3 Ml

Grandem Injection 3ml

Aristo Pharmaceuticals Pvt.ltd

AMPOULE of 1 ML
Pack of 5 ML
VIAL of 3 ML

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MRP ~~₹114~~

₹93.48

₹38.00/ML

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Composition

Granisetron (1 Mg)

Grandem Injection 3ml is primarily used to manage nausea and vomiting related to cancer treatments and surgery. This medicine belongs to a group known as antiemetics.

Apart from its main use, this medicine also helps in the prevention and management of nausea and vomiting triggered by radiation therapy. It's proven effective in controlling postoperative nausea and vomiting, providing relief to patients undergoing surgical procedures.

Before you start using this medicine, it's crucial to consult your doctor, who will guide you on the correct dosage and frequency. Do inform your doctor about any existing health conditions or medicines you are currently taking. If you notice any side effects while on this medicine, notify your doctor immediately. For optimal results, continue using the medicine for your doctor's entire duration.

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Grandem Injection 3ml is used for the following:

Managing nausea and vomiting caused by cytotoxic chemotherapy
Controlling nausea and vomiting due to radiation therapy
Preventing and managing postoperative nausea and vomiting

Directions for Use of Grandem Injection 3ml

When administering Grandem Injection 3ml, follow these steps:

The injection is to be administered only by a trained healthcare professional.
It should not be self-administered at home.
Always follow your doctor's advice regarding the timing of your injections.
If you are due an injection but cannot reach your doctor's office, consult your doctor about rescheduling.
Do not attempt to catch up on missed doses without consulting your doctor.

Grandem Injection 3ml is administered intravenously.

You may experience some common side effects while using Grandem Injection 3ml:

Headache
Constipation
Diarrhoea
Abdominal pain
Dizziness
Insomnia
Fatigue

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing Grandem Injection 3ml. However, if you experience serious side effects or worsening symptoms, please consult your doctor.

Here are some suggestions to manage common side effects:

Dyspepsia: Follow the diet plan recommended by your doctor.
Fatigue: Avoid activities your doctor has advised against and follow their recommendations.

Grandem Injection 3ml contains granisetron (1 mg), which acts on your body in the following ways:

5-HT3 Receptor Antagonist: Granisetron works by specifically targeting and blocking the 5-HT3 receptors located in your body's chemoreceptor trigger zone and gastrointestinal tract. These receptors are part of the mechanism that triggers the urge to vomit.
Serotonin Inhibitor: When granisetron blocks the 5-HT3 receptors, it effectively inhibits the activity of serotonin. Serotonin is a neurotransmitter that plays a significant role in initiating the vomiting reflex. This action helps reduce nausea and vomiting associated with cancer treatments and surgery.

Pregnancy

Caution is advised while taking Grandem Injection 3ml if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

Always consult your doctor before using this medicine if you are breastfeeding.

Alcohol

To ensure safety, it's recommended to discuss your alcohol consumption with your doctor.

Liver

Even though Grandem Injection 3ml doesn't require dosage adjustment in patients with liver issues, it's advisable to consult your doctor before using this medicine if you have liver-related concerns.

Kidney

Grandem Injection 3ml doesn't necessitate dosage adjustment in patients with kidney impairment. However, if you have a history of kidney problems, it's wise to discuss this with your doctor before taking this medicine.

Using Machines & Driving

Grandem Injection 3ml may cause dizziness or somnolence. If affected, refrain from driving or operating heavy machinery. Always discuss these risks with your doctor.

Allergy

If you're allergic to granisetron or any other ingredients in Grandem Injection 3ml, do not use this medicine. Contact your doctor immediately if you experience any allergic reactions.

Children

The use of Grandem Injection 3ml has been established as safe and effective in children aged above 2 years for the prevention of nausea and vomiting induced by chemotherapy. Always consult your doctor before giving any medicine to a child.

Older Patients

No overall differences were observed between elderly and younger patients regarding the safety or effectiveness of Grandem Injection 3ml. Nonetheless, some older individuals may be more sensitive. Caution is advised if patients are above 70 years of age.

Drug-Drug Interactions

Grandem Injection 3ml interacts with the following medicines:

Serotonergic medications: Using Grandem Injection 3ml with other serotonergic medicines like SSRI antidepressants (such as fluoxetine and sertraline) or triptans (like sumatriptan and zolmitriptan) can increase the risk of serotonin syndrome, a potentially serious condition.
Antifungals: If you take strong CYP3A4 inhibitors like ketoconazole or itraconazole alongside Grandem Injection 3ml, the latter may increase the levels of granisetron in your blood, which could lead to more side effects.
Antibiotics: Taking strong CYP3A4 inducers such as rifampin alongside Grandem Injection 3ml may reduce granisetron levels in your blood. This could make the medicine less effective in managing your symptoms.

Drug-Food Interactions

No specific food interactions have been reported with Grandem Injection 3ml.

Drug-Disease Interactions

Grandem Injection 3ml interacts with the following diseases:

Gastrointestinal motility disorders: Grandem Injection 3ml might slow down your gut movements. So, if you have conditions that affect bowel transit and motility, you should be cautious.
Cardiovascular disease: Grandem Injection 3ml can cause QT prolongation, a heart rhythm disorder. So, if you have pre-existing heart rhythm problems or cardiac conduction disorders, be careful while using Grandem Injection 3ml.

Daily Dose

Your doctor should administer the daily dose of Grandem Injection 3ml as prescribed. The dosage may vary based on individual factors, such as the severity of the condition and response to treatment. It is important to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

An overdose is highly unlikely for this medication as it is administered by a skilled healthcare professional.

Missed Dose

If you forget to take your Grandem Injection 3ml as scheduled, consult your doctor for advice.

Store Grandem Injection 3ml in the refrigerator or (2°C - 8°C). Do Not Freeze.
Protect the injection from light.
It's crucial to keep this medicine out of the reach of children.
Pay attention to the expiry date and make sure you use this medicine before it.

When undergoing chemotherapy or radiotherapy, eating small, frequent meals can help manage nausea and vomiting. This applies to both adults and if Grandem Injection 3ml is prescribed for your child.
Staying hydrated is crucial, particularly if vomiting occurs. Sip water or clear liquids slowly throughout the day to maintain hydration levels.

Fact Box

Drug Category	5-HT3 Antagonist
Therapeutic Category	Antiemetic
Available Dosage Types	Injection
Habit Forming	No
Ailment	Chemotherapy-induced nausea, Radiation-induced vomiting, Postoperative nausea

What is Grandem Injection 3ml used for?

Grandem Injection 3ml is used to prevent and manage nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery.

How does Grandem Injection 3ml work?

Grandem Injection 3ml contains granisetron which blocks the action of a substance in the body called serotonin, reducing the urge to vomit or feel nauseous.

Can pregnant women use Grandem Injection 3ml?

It should only be used if clearly needed and after consulting your doctor.

Can nursing mothers use Grandem Injection 3ml?

Consult your doctor before using it while breastfeeding.

Can children use Grandem Injection 3ml?

Yes, children above 2 years can use Grandem Injection 3ml to manage nausea and vomiting caused by chemotherapy. Always consult a doctor first.

Are there any side effects of using Grandem Injection 3ml?

Yes, some common side effects include headache, constipation, diarrhoea, abdominal pain, dizziness, insomnia and fatigue.

Can I use other medicines while using Grandem Injection 3ml?

Some medicines may interact with Grandem Injection 3ml. Always tell your doctor about any other medications you're taking to ensure safe use.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

23 A, Shah Industrial Estate, Off Veera Desai Rd, Andheri West, Mumbai, Maharashtra 400053

Country of origin: INDIA

References

Heron Therapeutics, Inc. (2016). Highlights of prescribing information for SUSTOL [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/022445s000lbl.pdf
Unknown. (n.d.). Granisetron hydrochloride injection. In Unknown [Unknown]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/077963Orig1s016,%20077297Orig1s016,%20078392Orig1s017lbl.pdf
Granisetron hydrochloride. (2018, August 7). Cancer.gov. https://www.cancer.gov/about-cancer/treatment/drugs/granisetronhydrochloride
Granisetron: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00889

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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