Isotrate 20 Mg Tablet 10

Isotrate 20 Tablet 10

Jagsonpal Pharmaceuticals Ltd

Strip of 10 Units

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Composition

Isosorbide-5-mononitrate / Isosorbide Mononitrate (20 Mg)

Strength:

20 MG 40 MG 10 MG

Isotrate 20 Tablet 10 is primarily used to prevent angina pectoris, a type of heart-related chest pain caused by coronary artery disease. This medicine belongs to a class of medications known as nitrates.

In addition to its main use, this tablet is also used to manage coronary heart disease and as a follow-up medication after a heart attack. It is further used to manage pulmonary hypertension, a condition that affects the blood vessels in the lungs.

Before taking this medicine, it's important that you consult your doctor for the correct dosage and frequency. Inform your doctor about any pre-existing conditions or ongoing medications to ensure this medicine is safe for you. If you notice any side effects while on this medication, notify your doctor immediately.

Isotrate 20 Tablet 10 is used for the following:

Prevention of angina pectoris, a type of heart-related chest pain caused by coronary artery disease
Management of coronary heart disease, a condition where the heart's blood supply is blocked or interrupted
Follow-up care after a heart attack to prevent further heart damage
Management of pulmonary hypertension, a type of high blood pressure that affects the arteries in the lungs and the right side of your heart

Directions for Use of Isotrate 20 Tablet 10

Here are some instructions to follow while taking Isotrate 20 Tablet 10:

Swallow the tablet whole with a glass of water. Avoid chewing or crushing it.
You can take it with or without food but try to take it at the same time each day.
Do not stop taking this medicine suddenly without consulting your doctor, even if your symptoms have improved.
Always remember to take this medicine regularly as prescribed by your doctor for effective results.

Isotrate 20 Tablet 10 is taken orally.

Isotrate 20 Tablet 10 may have the following common side effects:

Headache
Dizziness
Nausea
Increased sweating
Flushing: This refers to a warm feeling and redness on the face and neck.
Blurred vision: You might have difficulty focusing your eyes on objects.
Increased or decreased heartbeat
Cough and nasal congestion
Tinnitus: Perception of noise or ringing in the ears when there is no external sound present.
Edema
Fatigue
Flu-like symptoms
Malaise

Managing the Side Effects:

Most side effects are temporary and generally harmless, resolving on discontinuing the use of Isotrate 20 Tablet 10. However, if you experience any serious side effects or worsening of symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: If you feel nauseous, try taking Isotrate 20 Tablet 10s after meals to lessen this effect.
Sleepiness: Consider taking this medicine at night if it makes you feel drowsy during the day.

Isotrate 20 Tablet 10 contains Isosorbide Mononitrate (20 mg). The activity of this medicine can be described through its mechanism of action:

Conversion into Nitric Oxide: After administration, Isosorbide Mononitrate is converted into nitric oxide (NO)
Activation of Guanylate Cyclase: Nitric oxide activates an enzyme known as guanylate cyclase, which leads to an increase in cyclic guanosine monophosphate (cGMP) in smooth muscles
Vasodilation: The increased levels of cGMP result in relaxation and increased blood flow in arteries, veins, and cardiac tissue (vasodilation), thus reducing strain on the heart muscle and giving relief from angina

Pregnancy

Caution is advised while taking Isotrate 20 Tablet 10 if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, it's important to discuss this with your doctor before starting Isotrate 20 Tablet 10.

Alcohol

It is recommended that you avoid alcohol while taking this medicine, as it may increase certain side effects.

Liver

If you have liver health issues, caution is advised when taking Isotrate 20 Tablet 10s. Always consult your doctor before starting this medication.

Kidney

Isotrate 20 Tablet 10 should be used carefully by those with kidney health concerns. It's advisable to speak to your doctor before starting this medication.

Using Machines & Driving

Side effects of Isotrate 20 Tablet 10 may include dizziness and sleepiness. Avoid driving or operating machinery if you experience these side effects.

Allergy

If you are allergic to nitrates or any ingredients in this medicine, avoid using Isotrate 20 Tablet 10. Always inform your doctor of any allergies before starting a new medication.

Children

Isotrate 20 Tablet 10 is not typically prescribed for children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Isotrate 20 Tablet 10 under medical supervision, especially if they are above 70 years old, have liver or kidney issues, or are taking other medications.

Drug-Drug Interactions

Isotrate 20 Tablet 10 interacts with the following medicines:

Erectile dysfunction or pulmonary hypertension medication: Medicines like sildenafil and tadalafil, when taken concurrently with Isotrate 20 Tablet 10, can lead to severe low blood pressure, which may be life-threatening.
Antihypertensives: Medicines like atenolol, verapamil, and telmisartan can significantly reduce blood pressure when taken with Isotrate 20 Tablet 10, so blood pressure should be carefully monitored.
Psychiatric disorders and migraine medications: Concurrent use of certain medications may lead to low blood pressure symptoms, so close monitoring is necessary.

Drug-Food Interactions

There are no specific known food interactions with Isotrate 20 Tablet 10.

Drug-Disease Interactions

Isotrate 20 Tablet 10 interacts with the following diseases:

Low blood pressure or shock: Isotrate 20 Tablet 10 has a vasodilatory effect which can further decrease the blood pressure in patients already suffering from low blood pressure or shock.
Thyroid disorders, anemia, or increased intracranial pressure: This medication should be used cautiously in patients with these conditions as it may exacerbate symptoms.
Kidney or liver disorders: The metabolism and excretion of this medicine could be affected in patients with malfunctioning kidneys or liver. Hence, caution is advised while using Isotrate 20 Tablet 10 in such cases.

Daily Dose

The daily dose of Isotrate 20 Tablet 10 should be taken as advised by your doctor. Always adhere to the prescribed dosage and do not alter it without consulting your doctor.

Over Dose

Taking more than the prescribed dose of Isotrate 20 Tablet 10 could cause symptoms like headache, dizziness, and flushed skin. If you've taken more than the prescribed dose, inform your doctor immediately.

Missed Dose

If you forget to take Isotrate 20 Tablet 10, take it as soon as you remember. But if it's nearly time for the next dose, skip the missed one and continue with your regular schedule. Never increase your dosage without consulting your doctor.

Ensure Isotrate 20 Tablet 10 is stored at room temperature.
Keep the medicine away from direct sunlight and damp areas to prevent degradation.
Always keep this medication out of reach of children to avoid accidental ingestion.

Isotrate 20 Tablet 10 is used to manage heart-related conditions, so it is important to maintain a low-sodium diet. Excessive salt intake can increase blood pressure, putting additional strain on your heart.
Regular, moderate physical activity, such as brisk walking for 30 minutes a day, can help strengthen your heart and improve blood flow. However, remember not to overexert yourself and always consult your doctor before starting a new exercise regimen.

Fact Box

Drug Category	Coronary Vasodilator
Therapeutic Category	Nitrates
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Angina Pectoris, Coronary Heart Disease, Pulmonary Hypertension

What is the purpose of Isotrate 20 Tablet 10?

Isotrate 20 Tablet 10 is used to prevent heart-related chest pain and manage coronary heart disease. It isn't for immediate relief of sudden angina attacks.

How does Isotrate 20 Tablet 10 work in the body?

This medicine relaxes and widens blood vessels, reducing the strain on your heart and making it easier for your heart to pump blood around your body.

Can I drive or operate machinery after taking Isotrate 20 Tablet 10?

If you experience dizziness or sleepiness, avoid driving or operating machinery until these effects subside. Your ability to perform these activities might be impaired.

What precautions should I consider with Isotrate 20 Tablet 10?

Patients with low blood pressure, thyroid disorders, kidney or liver disorders, and those who are weak or malnourished should use this medicine cautiously.

Can pregnant or breastfeeding women take Isotrate 20 Tablet 10?

Caution is advised while taking Isotrate 20 Tablet 10 if you are pregnant or breastfeeding. It is best to consult your doctor before taking this medicine during these conditions.

Are there any common side effects of Isotrate 20 Tablet 10?

Common side effects include headache, dizziness, flushing, nausea, weakness, low blood pressure, rapid heartbeat, and sleepiness. Consult your doctor if they persist.

How should I store my Isotrate 20 Tablet 10?

Store your medicine at room temperature, away from direct sunlight, heat and moisture. Keep it out of reach of children and pets.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

T-210 J, Shahpur Jat,, New Delhi, Delhi, 110049

Country of origin: INDIA

References

monoket®. (2003). monoket® tablets. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020215s024lbl.pdf
DailyMed - ISOSORBIDE MONONITRATE tablet, extended release. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cd439861-2e23-4e0e-bcdc-48e2ebdc4943
NCATS Inxight Drugs — ISOSORBIDE MONONITRATE. (n.d.). https://drugs.ncats.io/substance/LX1OH63030
Isosorbide mononitrate: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01020

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