Lastavin S 100 Mg Tablet 14

Lastavin S 100 Tablet 14

Ajanta Pharma Ltd

Strip of 14 Units

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MRP ~~₹680~~

₹339.32

₹48.57/Units

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Composition

Sacubitril (49 Mg) + Valsartan (51 Mg)

Lastavin S 100 Tablet 14 is primarily used to prevent heart failure. It's a combination medicine that belongs to the class of angiotensin receptor neprilysin inhibitors (ARNIs).

Besides its main use in heart failure, the medicine also helps reduce symptoms like shortness of breath, swelling in the feet and ankles, and fatigue. When used with other heart failure medicines and lifestyle changes, it can significantly improve quality of life and decrease the risk of hospitalisation due to worsening heart failure.

Before starting this medicine, inform your doctor about any pre-existing conditions or ongoing medications. If you experience any side effects while taking it, notify your doctor immediately. For the best results, continue taking the medicine for the duration your doctor prescribes.

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Lastavin S 100 Tablet 14 can be used for the following:

Managing heart failure in adults
Relief from shortness of breath associated with heart failure
Decreasing swelling in the feet and ankles due to heart failure
Reducing fatigue linked with heart failure
Enhancing quality of life for those suffering from heart failure
Minimising the risk of hospitalisation due to worsening heart conditions

Directions for Use of Lastavin S 100 Tablet 14

Here's how you should take Lastavin S 100 Tablet 14:

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet.
If you have trouble swallowing it whole, you can crush it and mix it with water before taking it.
Always consult your doctor if you have any concerns or questions regarding how to take this medicine.

Lastavin S 100 Tablet 14 is taken orally.

Side Effects of Lastavin S 100 Tablet 14

While consuming Lastavin S 100 Tablet 14, you may experience some side effects. Please note the following:

Low blood pressure (hypotension)
Muscle weakness or irregular heartbeat
Kidney problems
Dizziness
Cough
Headache
Fatigue

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing Lastavin S 100 Tablet 14. However, if you experience serious side effects or worsening symptoms, please consult your doctor.

Here is how you can manage some common side effects:

Low blood pressure (hypotension): Try getting up slowly from a sitting or lying position to minimise dizziness.
High potassium levels in the blood (hyperkalaemia): If you experience symptoms like muscle weakness or irregular heartbeat, consult your doctor, who may adjust your treatment as necessary.

Lastavin S 100 Tablet 14 contains two active ingredients:

Sacubitril (49 mg): This component inhibits neprilysin. Neprilysin is an enzyme that breaks down natriuretic peptides. These peptides help relax blood vessels, increase sodium and water excretion and reduce strain on the heart. By inhibiting neprilysin, sacubitril increases the levels of these beneficial peptides.
Valsartan (51 mg): As an angiotensin II receptor blocker (ARB), valsartan works by blocking the action of angiotensin II. This hormone causes blood vessels to narrow and increases blood pressure and fluid retention. By blocking angiotensin II receptors, valsartan helps relax blood vessels, reduce blood pressure and decrease the workload on the heart.

These combined actions contribute to the overall effectiveness of Lastavin S 100 Tablet 14 in managing heart failure.

Pregnancy

Lastavin S 100 Tablet 14 is not recommended if you are pregnant, as it can potentially harm the unborn baby. If you are planning to conceive, consult your doctor before starting this medication.

Breastfeeding

It's best to avoid Lastavin S 100 Tablet 14 while breastfeeding due to potential risks to the baby. Your doctor can guide you on the best course of action.

Alcohol

While taking Lastavin S 100 Tablet 14, it's wise to limit alcohol consumption as it might intensify some side effects like dizziness or fatigue.

Liver

If you have liver problems, caution is advised when taking Lastavin S 100 Tablet 14. Your doctor may need to adjust your dosage or monitor your liver function.

Kidney

Patients with severe kidney problems or those on dialysis should use Lastavin S 100 Tablet 14 with caution. Consult your doctor for dose adjustments or special monitoring.

Using Machines & Driving

Lastavin S 100 Tablet 14 might cause dizziness or fatigue. If you experience these, avoid driving or operating heavy machinery until you feel well again.

Allergy

Avoid Lastavin S 100 Tablet 14 if you are allergic to sacubitril, valsartan, or any other ingredients in the tablet. Discuss any known allergies with your doctor before starting this medicine.

Children

Lastavin S 100 Tablet 14 is not recommended for use in children under 18 without guidance from a doctor.

Older Patients

Elderly patients should take Lastavin S 100 Tablet 14 under medical supervision as they may be more susceptible to its blood pressure-lowering effects and potential kidney issues.

Interactions of Lastavin S 100 Tablet 14

Drug-Drug Interactions

Lastavin S 100 Tablet 14 interacts with the following medicines:

ACE inhibitors: Medicines such as enalapril or lisinopril can interact with Lastavin S 100 Tablet 14, leading to a high risk of angioedema, an allergic reaction causing facial and throat swelling.
Potassium-sparing diuretics and potassium supplements: When used with Lastavin S 100 Tablet 14, these can increase the risk of having high potassium levels in your blood (hyperkalaemia).
NSAIDs: Medicines like ibuprofen or naproxen may decrease the blood pressure-lowering effect of Lastavin S 100 Tablet 14 and increase the risk of kidney problems.

Drug-Food Interactions

There are no specific interactions of this medicine with food.

Drug-Disease Interactions

Lastavin S 100 Tablet 14 interacts with the following diseases:

Kidney Disease: People with severe kidney problems may require dose adjustments or special monitoring when taking this medication.
Liver Disease: Lastavin S 100 Tablet 14 should be used cautiously in people with liver problems. Dose adjustments may be necessary.

Daily Dose

Your doctor will prescribe the appropriate daily dose of Lastavin S 100 Tablet 14. This dosage may be adjusted based on your response to the medicine and the severity of your condition. It's important not to exceed the prescribed dose without consulting your doctor.

Over Dose

In case you accidentally take more than the prescribed dose of Lastavin S 100 Tablet 14, you might feel dizzy or experience a headache. Avoid panic and inform your doctor about it.

Missed Dose

If you miss a dose of Lastavin S 100 Tablet 14, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue as per your regular schedule. Remember never to increase your dosage without consulting your doctor.

Store Lastavin S 100 Tablet 14 in a closed container at room temperature, ideally below 30°C.
Keep the medicine away from direct sunlight and moisture.
Ensure it is out of reach of children.
Always check the expiry date.

Maintain a low-sodium diet to help manage blood pressure levels and reduce strain on your heart.
Incorporate regular, gentle exercises into your routine, such as walking or yoga, to help improve cardiovascular health. Always consult your doctor regarding the type and intensity of exercise suitable for you.

Fact Box

Drug Category	Angiotensin Receptor Neprilysin Inhibitor
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Heart Failure, High Blood Pressure

What is Lastavin S 100 Tablet 14 used for?

This medicine is primarily used to manage heart failure symptoms like shortness of breath and fatigue and to improve the heart's pumping ability.

How does Lastavin S 100 Tablet 14 work?

It contains two ingredients that relax blood vessels, increase sodium and water removal from the body, reduce strain on the heart, and lower blood pressure.

Can I take Lastavin S 100 Tablet 14 with food?

Yes, you can take this medicine with or without food. If you struggle to swallow it whole, you can crush it and mix it with water.

What should I do if I miss a dose of Lastavin S 100 Tablet 14?

If you miss a dose, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue your regular schedule.

Are there any side effects of Lastavin S 100 Tablet 14?

Common side effects include low blood pressure, high potassium levels in the blood, kidney problems, dizziness, coughing, headaches, and fatigue.

Can pregnant women take Lastavin S 100 Tablet 14?

No, this medicine shouldn't be taken during pregnancy as it can harm the foetus. Women of childbearing age should use effective contraception while taking it.

Can I stop taking Lastavin S 100 Tablet 14 abruptly?

No, abruptly stopping this medicine isn't advised. Always consult your doctor before discontinuing any medication.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

54, Sir Mathuradas Vasanji Rd, Hanuman Nagar, Andheri East, Mumbai, Maharashtra 400053

Country of origin: INDIA

References

Novartis Pharmaceuticals Corporation. (2021). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
Entresto. (n.d.). Entresto Summary of product characteristics. https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
CARMADA. (n.d.). Sacubitril and Valsartan tablets [Report]. https://www.sanofi.in/dam/jcr:2e79c610-7644-4d4c-bf51-1651a1804410/Carmada%20PI-%20Valsartan+Secubitril-Annotated-Nov%202023.pdf
Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177
Kido, K., Colvin, B. M., Szymanski, T. W., & Guglin, M. (2022). Sacubitril/Valsartan Off-Label uses for heart failure. Journal of Cardiac Failure, 28(7), 1185–1201. https://doi.org/10.1016/j.cardfail.2022.03.348

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