Lefunol 20 Tablet 10

Knoll Healthcare Pvt. Ltd.

Strip of 10 Units

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MRP ~~₹257~~

₹128.24

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Composition

Leflunomide (20 Mg)

Strength:

20 MG 10 MG

Lefunol 20 Tablet is primarily prescribed for the treatment of rheumatoid arthritis and psoriatic arthritis in adults. It belongs to a class of medications known as disease-modifying antirheumatic drugs (DMARDs), which are designed to slow the progression of these autoimmune conditions and alleviate their symptoms.

This medicine suppresses the immune system. It targets the overactive immune cells involved in causing inflammation, pain, and joint damage, which are common features of rheumatoid and psoriatic arthritis.

Before beginning treatment with this medicine, it is essential to consult your doctor, who will determine the appropriate dosage and frequency based on your specific condition and health profile. Ensure that you inform your doctor about any pre-existing medical conditions, ongoing medications, or allergies to avoid potential complications. It is also crucial to report any side effects, such as gastrointestinal discomfort, skin reactions, or signs of infection, to your doctor promptly.

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Lefunol 20 Tablet is used for the following:

Reduction of signs and symptoms in adults with active rheumatoid arthritis
Slowing down structural damage in adults with active rheumatoid arthritis
Improvement of physical function in adults with active rheumatoid arthritis
Management of symptoms in adults with active psoriatic arthritis

Directions for Use of Lefunol 20 Tablet 10

Follow these instructions while taking Lefunol 20 Tablet:

Swallow the tablet whole with a glass of water.
Avoid crushing, breaking, or chewing the tablet.
Do not alter the dosage or stop taking the medicine without consulting your doctor first.

Lefunol 20 Tablet is taken orally.

Lefunol 20 Tablet may have the following common side effects:

Diarrhoea
Nausea
Abdominal pain
Oral ulcers
Hair loss
Rash
Headache
Dizziness

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Lefunol 20 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: Try taking Lefunol 20 Tablet with food.
Nausea: Consider taking this medicine after meals to lessen this effect.

Lefunol 20 Tablet contains leflunomide (20 mg). This medicine acts on the body through the following mechanisms:

Inhibition of Pyrimidine Synthesis: Leflunomide blocks the production of pyrimidine, a crucial compound needed for the rapid multiplication of cells. This action targets overactive immune cells responsible for inflammation in arthritis.
Immune System Suppression: By inhibiting pyrimidine synthesis, leflunomide reduces immune system activity, thereby alleviating inflammation, pain, and joint damage while slowing the progression of rheumatoid and psoriatic arthritis.

Pregnancy

Lefunol 20 Tablet is strictly contraindicated during pregnancy as it can cause harm to the developing fetus. If you are pregnant or planning to conceive, discuss this with your doctor before starting the medication.

Breastfeeding

Breastfeeding is not recommended while taking Lefunol 20 Tablet, as this medicine may pass into breast milk and harm the nursing infant. Consult your doctor to understand the risks and explore alternative treatment options.

Alcohol

Avoid consuming alcohol while on Lefunol 20 Tablet as it can increase the risk of liver damage. Discuss alcohol use with your doctor, especially if you have a history of liver problems.

Liver

Caution is advised when using Lefunol 20 Tablet in patients with mild to moderate liver impairment. It is contraindicated in cases of severe liver disease. This medicine may affect liver function, so routine liver function tests may be required. If you have any liver conditions, inform your doctor before starting treatment.

Kidney

Patients with a history of kidney problems should use Lefunol 20 Tablet cautiously. Kidney function should be monitored, and your doctor will decide whether this medication is suitable for you.

Using Machines & Driving

Lefunol 20 Tablet does not typically impair your ability to drive or operate machinery. However, if you experience side effects like dizziness, fatigue, or weakness, it is best to avoid such activities and consult your doctor.

Allergy

Do not take Lefunol 20 Tablet if you are allergic to leflunomide or any of its ingredients. Always check the composition of the medicine and consult your doctor if you have a history of allergies.

Children

Lefunol 20 Tablet is not recommended for children under 18 years of age. Always consult a pediatrician or healthcare provider before giving this medication to children.

Older Patients

Older patients (above 70 years) should take Lefunol 20 Tablet under strict medical supervision, as they may be more susceptible to side effects such as liver or kidney complications. Your doctor may adjust the dosage and closely monitor your health during treatment.

Drug-Drug Interactions

Lefunol 20 Tablet interacts with the following medicines:

Hepatotoxic medicines: Medicines like methotrexate can interact with Lefunol 20 Tablet, potentially increasing the risk of serious liver injury.
Anticoagulants: Medicines like warfarin may interact with Lefunol 20 Tablet, potentially increasing the anticoagulant effect.
Immunosuppressants: Combined use with other immune-suppressing medicines such as azathioprine or cyclosporine may increase the risk of infections.

Drug-Food Interactions

None

Drug-Disease Interactions

Lefunol 20 Tablet interacts with the following diseases:

Severe Liver Disease: This medication is contraindicated in patients with severe liver impairment as it may worsen liver function.
Severe Infections: Patients with active severe infections should avoid starting Lefunol 20 Tablet until the infection is fully treated, as the medication suppresses the immune system.
Immune Deficiency: Due to its immunosuppressive effects, Lefunol 20 Tablet is not recommended for individuals with severe immune deficiencies.
Bone Marrow Disorders: This medicine can affect blood cell production, including white blood cells, red blood cells, and platelets, and is not suitable for patients with impaired bone marrow function.

Daily Dose

The daily dose of Lefunol 20 Tablet should be taken as directed by your doctor. The prescribed dosage may vary based on individual circumstances, such as the severity of your condition and how you respond to the medicine. It's crucial to adhere to your doctor's instructions and not exceed the recommended dose without seeking medical advice.

Over Dose

If you accidentally take more than the recommended dose, you might experience side effects such as nausea, abdominal discomfort, or dizziness. Should these symptoms persist, inform your doctor. Always stick to the prescribed dosage to avoid such instances.

Missed Dose

If you forget to take your Lefunol 20 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and carry on with your normal schedule. Never double up your dosage without consulting your doctor.

Always keep Lefunol 20 Tablet in its original packaging.
Store it at room temperature, ideally below 25°C.
Keep it away from direct light and moisture to maintain its efficacy.
Make sure the medicine is kept out of the reach of children.
Remember to check the expiry date on the packet before using the medicine.

If you're taking Lefunol 20 Tablet for rheumatoid or psoriatic arthritis, aim to maintain a balanced diet rich in Omega-3 fatty acids (found in fish, walnuts, flaxseeds) which may help reduce inflammation.
Regular low-impact exercises like swimming or cycling can help keep your joints flexible and strong without causing pressure or pain. Always consult your doctor before starting any new exercise routine.

Fact Box

Drug Category	Pyrimidine Synthesis Inhibitor
Therapeutic Category	DMARD (Disease-Modifying Antirheumatic Medicines)
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Rheumatoid Arthritis, Psoriatic Arthritis

What is Lefunol 20 Tablet used for?

Lefunol 20 Tablet is used to manage symptoms and slow down the progression of rheumatoid and psoriatic arthritis in adults.

How does Lefunol 20 Tablet work?

Lefunol 20 Tablet works by inhibiting the production of a substance needed for rapidly dividing cells, thus reducing inflammation and slowing arthritis progression.

Can Lefunol 20 Tablet be taken with food?

You must take the medicine as directed by your doctor.

What are the common side effects of Lefunol 20 Tablet?

Side effects can include diarrhoea, nausea, abdominal pain, oral ulcers, hair loss, rash, headache, and dizziness. Consult your doctor if these persist or worsen.

Is Lefunol 20 Tablet safe during pregnancy?

No, Lefunol 20 Tablet may cause birth defects and should not be taken during pregnancy. Women must use reliable contraception during and after treatment.

What precautions should I take while using Lefunol 20 Tablet?

Inform your doctor about all your health conditions, especially liver disease, immunodeficiency, bone marrow problems, diabetes, and any active or chronic infections before starting this medication.

Can Lefunol 20 Tablet interact with other medicines?

Yes, it may interact with several medications, such as hepatotoxic medicines and anticoagulants like warfarin. Always inform your doctor about all medicines you're currently taking.

Last Updated On 12 Mar. 2025 | 12:15PM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 6 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 11 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

M17, Pharma Tower,, Phase-1, Badli Industrial Area,, Badli, Delhi, 110042

Country of origin: INDIA

References

Unknown, U. (2002). ARAVA tablets. In Unknown [Unknown]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/20905slr007,20905se1-006_arava_lbl.pdf
ARAVA. (n.d.). ARAVA Tablets (leflunomide) 10 mg, 20 mg, 100 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
Padda, I. S., & Goyal, A. (2023, June 3). Leflunomide. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK557799/
Leflunomide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01097
Leflunomide: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a600032.html

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