Macitent 10 Mg Tablet 10

Macitent Tablet 10

Msn Laboratories Ltd

Strip of 10 Units

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MRP ~~₹2109.8~~

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Composition

Macitentan (10 Mg)

Macitent Tablet is used mainly to manage pulmonary arterial hypertension (PAH), a condition characterised by high blood pressure in the arteries that carry blood from the heart to the lungs. It belongs to a group of medicines referred to as endothelin receptor antagonists.

In addition to its primary purpose, this medicine also aids in decreasing the workload on your heart, hence improving your overall exercise capacity. It also helps in delaying the progression of PAH, contributing to better health outcomes for those struggling with this condition.

Before starting this medication, it's important to consult your doctor for the correct dosage and frequency. You should inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects while on this medication, notify your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

Macitent Tablet is used for the following:

Long-term management of pulmonary arterial hypertension (PAH) in adults
Delaying disease progression in patients with PAH
Enhancing exercise capacity in adults suffering from PAH
Use as a standalone therapy or in combination with other medicines to manage PAH
Remember, this medicine is intended for adults and should be used under proper medical guidance.

Directions for Use of Macitent Tablet 10

Here's how to take Macitent Tablet:

Swallow the tablet whole with a glass of water.
Do not crush, chew, or break the tablet.
Always remember to follow your doctor's instructions when taking this medicine. If you have questions about how to take Macitent Tablet, don't hesitate to ask your doctor.

Macitent Tablet is taken orally.

Macitent Tablet may have the following common side effects:

Nasopharyngitis: This is inflammation of the nasopharynx, the area behind your nose and above your mouth. You might feel like you have a cold.
Headache
Anaemia: This condition occurs when you don't have enough red blood cells, making you feel tired and weak.
Bronchitis: An inflammation in your bronchial tubes which carry air to your lungs. You could experience coughing, shortness of breath or chest discomfort.
Urinary tract infection
Pharyngitis: This is inflammation of the pharynx, which is in the back of the throat. It usually results in a sore throat.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Macitent Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Bronchitis: Consider taking this medicine at night if coughing or chest discomfort keeps you awake.
Pharyngitis: If a sore throat becomes bothersome, try taking Macitent Tablet with food or milk to lessen this effect.

Macitent Tablet contains macitentan (10 mg) and works in your body in the following ways:

Blocks endothelin-1: Macitentan blocks the effects of a naturally occurring substance in your body called endothelin-1, which causes blood vessels to narrow and raises blood pressure.
Promotes vasodilation: By blocking the receptors of endothelin-1, macitentan promotes vasodilation, which is the widening of your blood vessels, helping reduce the blood pressure in your pulmonary arteries.
Reduces cell proliferation: Macitentan also reduces the multiplication of cells in the pulmonary arteries, leading to a decrease in pulmonary vascular resistance and subsequently lowering the pressure in your pulmonary arteries.

Pregnancy

Macitent Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Caution is advised for lactating women. The benefits of breastfeeding should be considered along with your clinical need for Macitent.

Alcohol

It's always a good idea to consult your doctor before consuming alcohol while on medication.

Liver

Caution is advised while taking Macitent Tablet in case of mild to moderate liver impairment. It is not recommended for severe liver diseases. If you have liver problems, discuss them with your doctor before starting Macitent Tablet.

Kidney

Caution is advised before using Macitent Tablet if you have a history of any kidney problems. It is a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

No specific precautions exist regarding the use of heavy machinery or driving while using Macitent Tablet. However, if you feel unwell or experience any side effects, avoid such activities and consult your doctor.

Allergy

Macitent Tablet should not be used if you're allergic to macitentan or any other ingredients in the tablet. If you've had an allergic reaction to similar medicines in the past, let your doctor know.

Children

The safety and efficacy of Macitent Tablet have not been established in children under 18 years of age. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Macitent Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Macitent Tablet interacts with the following medicines:

Antifungals: Medicines such as ketoconazole may increase the exposure to macitentan, potentially raising the risk of side effects.
Antibiotics: Medicines like rifampin could reduce the effectiveness of Macitent Tablet by lowering macitentan levels in the body.
Other endothelin receptor antagonists: Concomitant use of medicines such as bosentan and ambrisentan is not recommended due to potential interaction risks.
Certain immunosuppressants: Macitent Tablet should not be used with cyclosporine, everolimus, or sirolimus as it may increase exposure to these medicines potentially leading to increased side effects.

Drug-Food Interactions

Drug-Disease Interactions

Macitent Tablet interacts with the following diseases:

Severe hepatic impairment: Macitent Tablet may cause fluid retention and is not recommended for those with severe liver disease.
Anaemia: Patients taking this medicine should be monitored for signs of anaemia as it might worsen their condition.

Daily Dose

The daily dose of Macitent Tablet should be as recommended by your doctor. The dosage may vary based on individual factors like the severity of the condition and how you respond to the medication. Always adhere to the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

In case of an accidental overdose, general supportive measures and symptomatic treatment should be provided as needed. Macitent Tablet is highly protein-bound and is not expected to be dialyzable.

Missed Dose

If you forget to take your regular dose of Macitent Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosage schedule. Never adjust your dosage without consulting your doctor.

Store Macitent Tablet in a cool and dry place, ideally below 30°C.
Keep this medicine out of reach of children and pets.
Do not expose Macitent Tablet to direct sunlight, heat or moisture.
Always remember to use the medicine before its expiry date.

Engage in regular physical activity like walking or stretching as it can help improve your circulation, reducing strain on your heart.
Adopt a low-sodium diet as consuming too much salt can increase blood pressure in your pulmonary arteries, worsening PAH symptoms. Always consult your doctor for specific dietary advice.

Fact Box

Drug Category	Endothelin Receptor Antagonist
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Pulmonary Arterial Hypertension

What is Macitent Tablet used for?

Macitent Tablet is used to manage pulmonary arterial hypertension (PAH), a condition where the blood pressure in the arteries to your lungs is too high.

How does Macitent Tablet work?

Macitent Tablet works by blocking a substance called endothelin-1, which causes blood vessels to narrow. This helps widen your blood vessels and reduces blood pressure.

How should I take my Macitent Tablet?

You must take the medicine as directed by your doctor.

What are the side effects of taking Macitent Tablet?

Possible side effects may include headache, urinary tract infection, bronchitis, and flu-like symptoms. Consult your doctor if any side effects persist or worsen.

Can I take Macitent Tablet if I am pregnant?

No, Macitent Tablet should not be taken during pregnancy as it may harm the foetus. Always consult your doctor for advice about medicines during pregnancy.

Can I take other medicines alongside Macitent Tablet?

Some medicines might interact with Macitent Tablet and can affect how it works. Always inform your doctor about any other medications you are taking.

What should I do if I miss a dose of Macitent Tablet?

If you miss a dose of Macitent Tablet, take it as soon as you remember unless it's nearly time for the next dose - don't double up on doses.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad, Telangana 500018

Country of origin: INDIA

References

Actelion Pharmaceuticals US, Inc. (2019). Highlights of prescribing information [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/204410s017lbl.pdf
Opsumit. (n.d.). Opsumit 10 mg film-coated tablets. In SUMMARY OF PRODUCT CHARACTERISTICS. https://ec.europa.eu/health/documents/community-register/2017/20170717138517/anx_138517_en.pdf
Australian Public Assessment Report for macitentan. (2014). In Therapeutic Goods Administration, Therapeutic Goods Administration. https://www.tga.gov.au/sites/default/files/auspar-macitentan-140428.pdf
Janssen Inc. (2021). OPSUMIT Macitentan tablets. https://pdf.hres.ca/dpd_pm/00060736.PDF
Macitentan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB08932

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