Natrise 30 Mg Tablet 4

Natrise 30 Tablet 4

Sun Pharma Laboratories Ltd.

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Composition

Tolvaptan (30 Mg)

Strength:

15 MG 30 MG

Natrise Tablet is utilised to regulate low sodium levels in your blood, a condition known as hyponatraemia. This medicine falls under the vasopressin receptor antagonists category.

This medicine also manages hyponatraemia related to heart failure, liver cirrhosis, and syndrome of inappropriate antidiuretic hormone (SIADH). By enhancing serum sodium levels, it helps mitigate symptoms like nausea, fatigue, confusion and severe ones like seizures and coma.

You should take this medicine orally following your doctor's instructions. It's crucial to let your doctor know about any health conditions you have or any other medicines you're taking before starting this medicine. If you experience any side effects while using this medication, inform your doctor promptly. For effective results, continue taking the medicine for the duration prescribed by your doctor.

Natrise Tablet is used for the following:

Addressing low sodium levels in the blood, known as hyponatraemia.
Management of fluid overload related to heart failure.
Handling sodium imbalance in liver cirrhosis patients.
Correction of sodium levels in the syndrome of inappropriate antidiuretic hormone (SIADH).

Directions for Use of Natrise 30 Tablet 4

Follow the dosage and timing instructions provided by your doctor precisely.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Natrise Tablet is taken orally.

Natrise Tablet may have the following common side effects:

Thirst
Dry mouth
Asthenia: This refers to feeling weak or lacking energy.
Constipation
Polyuria: You might find you're going to the toilet to urinate more often than usual.
Hyperglycaemia: This could cause high blood sugar levels.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Natrise Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Thirst: Drinking plenty of water can help manage this common side effect.
Constipation: Try taking Natrise Tablet with or after meals to lessen this effect.

Natrise Tablet contains tolvaptan (30 mg) and works on your body as follows:

Vasopressin V2-Receptor Antagonism: Tolvaptan is a selective vasopressin V2-receptor antagonist. It blocks the binding and effects of vasopressin at the V2 receptors in your kidney collecting ducts. Vasopressin usually promotes water absorption in the kidneys.
Aquaresis: By inhibiting vasopressin's action, tolvaptan triggers an increased excretion of water (aquaresis), while preserving sodium in your body. This leads to more urine output, decreased body water, and a rise in serum sodium concentration.

Pregnancy

Caution is advised while taking Natrise Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

Natrise Tablet is contraindicated for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

It is best to avoid alcohol while being treated with Natrise Tablet, as it can worsen the side effects like dizziness, dehydration and liver problems.

Liver

Natrise Tablet should be avoided in patients with underlying liver disease. If you have liver problems, discuss them with your doctor before starting this medicine.

Kidney

Caution is advised before using Natrise Tablet if you have a history of any kidney problems. It is a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

There are no specific restrictions on driving or operating machinery while taking Natrise Tablet. However, if you experience any side effects like dizziness or fatigue, avoid such activities until you feel better.

Allergy

If you have a known allergy to tolvaptan or any other ingredients in Natrise Tablet, avoid using this medicine. Consult your doctor for alternatives.

Children

Natrise Tablet is not typically prescribed for children. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Natrise Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Natrise Tablet interacts with the following medicines:

CYP3A Inhibitors: Medicines such as ketoconazole, clarithromycin, ritonavir and saquinavir can significantly increase the levels of tolvaptan in the blood when taken alongside Natrise Tablet.
Vasopressin Analogues: Medicines like desmopressin which mimic the effects of vasopressin could have their effects reduced by Natrise Tablet.

Drug-Food Interactions

Drinking grapefruit juice while taking Natrise Tablet can increase tolvaptan levels in your blood.

Drug-Disease Interactions

Natrise Tablet interacts with the following diseases:

Liver Disease: If you have an underlying liver condition, taking Natrise Tablet could potentially exacerbate your condition.
High Potassium Levels: If you have a higher level of potassium in your blood (greater than 5 mEq/L), caution is advised while taking Natrise Tablet.
Autosomal Dominant Polycystic Kidney Disease (ADPKD): If you suffer from ADPKD, the use of Natrise Tablet is contraindicated.

Daily Dose

The recommended daily dose of Natrise Tablet should be taken as instructed by your doctor. Dosage can differ based on individual needs and response to the medication. Always consult your doctor before changing your dosage.

Over Dose

Overdosing on Natrise Tablet may result in excessive thirst, dry mouth, or high blood sugar levels. If you experience these symptoms after taking a higher dose than prescribed, inform your doctor.

Missed Dose

If you miss a dose of Natrise Tablet, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular schedule.

Store Natrise Tablet at room temperature.
Keep it in a tightly closed container to prevent exposure to moisture and light.
Ensure to keep this medicine out of the reach of children.
Always check the expiry date and ensure the medicine is used before it.

For managing hyponatraemia, which Natrise Tablet helps manage, try incorporating a low-sodium diet into your lifestyle. This means limiting processed foods and choosing fresh fruits, vegetables, and lean proteins.
As dehydration can occur during medication with Natrise Tablet, ensure you have an ample supply of drinking water available.

Fact Box

Drug Category	Vasopressin Receptor Antagonist
Therapeutic Category	Hyponatraemia Medicine
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Heart Failure, Liver Cirrhosis, SIADH

What is Natrise Tablet used for?

Natrise Tablet is primarily used to manage low sodium levels in the blood, often linked to conditions like heart failure and the syndrome of inappropriate antidiuretic hormone.

How does Natrise Tablet work?

Natrise Tablet contains tolvaptan, which blocks an action of a hormone that promotes water retention in the kidneys. This results in more water excretion, helping raise sodium levels.

How long does it take for Natrise Tablet to work?

The effects of Natrise Tablet start within 1-2 hours of taking it. A substantial increase in urine output is seen within 2-4 hours and sodium levels start rising within 4-8 hours.

Can I drink alcohol while taking Natrise Tablet?

It's best to avoid alcohol while taking this medicine as it can exacerbate side effects like dizziness, dehydration and liver problems. Always consult your doctor for specific advice.

What happens if I miss a dose of Natrise Tablet?

If you miss a dose, take it as soon as you remember. However, if it's close to your next dose, skip the missed one.

Are there any specific foods or drinks I should avoid while on Natrise Tablet?

Patients should refrain from drinking grapefruit juice during treatment with Natrise Tablet as it can increase tolvaptan levels in the blood.

Does Natrise Tablet have any side effects?

Yes, common side effects include thirst, dry mouth, fatigue, constipation and increased urination. Most side effects don't require medical attention and resolve over time.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

References

Otsuka. (2009). Highlights of prescribing information [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/022275s017lbl.pdf
Tolvaptan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06212
PubChem. (n.d.). Tolvaptan. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Tolvaptan
Reilly, T., & Chavez, B. (2009, October 1). Tolvaptan (Samsca) for hyponatremia: Is it worth its salt? PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799145/

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