Nitrobest 100 Mg Tablet 10

Nitrobest Tablet 10

Q: What is Nitrobest Tablet used for?

Nitrobest Tablet is used to manage and prevent certain urinary tract infections (UTIs) caused by specific types of bacteria.

Q: How does Nitrobest Tablet manage UTIs?

The active ingredient, nitrofurantoin, disrupts vital processes in bacterial cells present in the urinary tract, effectively managing the infection.

Q: Can Nitrobest Tablet be used for kidney infections or abscesses?

No, Nitrobest Tablet is not indicated for managing kidney infections or perinephric abscesses. Consult your doctor for suitable alternatives.

Q: How should Nitrobest Tablet be taken?

You must take the medicine exactly as prescribed by your doctor.

Q: What are some common side effects of Nitrobest Tablet?

Common side effects include nausea, vomiting, diarrhoea, loss of appetite, headache, dizziness, and brown discolouration of urine.

Q: Can I take antacids while on Nitrobest Tablet?

Antacids containing magnesium trisilicate can decrease the absorption of nitrofurantoin. Consult your doctor before taking any other medicines.

Q: Is Nitrobest Tablet safe for pregnant women and nursing mothers?

Avoid Nitrobest Tablet during late pregnancy and labour. Nursing mothers should use an alternate feeding method due to excretion in breast milk.

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Composition

Nitrofurantoin (100 Mg)

Nitrobest Tablet is primarily used to manage urinary tract infections (UTIs) caused by certain types of bacteria. It's an antibiotic medication, specifically belonging to the nitrofuran class of antimicrobials.

Besides its main use for UTIs, this medicine is also utilised for long-term preventative therapy in some patients who are prone to frequent UTIs. However, it isn't effective against kidney infections or perinephric abscesses.

Before starting this medicine, it's crucial to consult your doctor for dosage instructions and possible side effects. Inform your doctor about any pre-existing conditions and ongoing medications. If you observe any side effects while taking this medicine, immediately notify your doctor. Remember to complete the course of the medicine exactly as advised by your doctor for optimal results.

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Nitrobest Tablet is used for the following:

Managing uncomplicated lower urinary tract infections caused by susceptible strains of bacteria such as Escherichia coli, Enterococcus species, Staphylococcus aureus, Klebsiella species, and Enterobacter species.
Preventing recurrent urinary tract infections in certain patients who are prone to frequent episodes.

Directions for Use of Nitrobest Tablet 10

Follow these instructions while taking Nitrobest Tablet:

Follow the dosage and timing instructions provided by your doctor precisely.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Nitrobest Tablet is taken orally.

Nitrobest Tablet might have the following side effects:

Nausea
Vomiting
Diarrhoea
Loss of appetite
Headache
Dizziness
Brown discolouration of urine
Peripheral neuropathy: This refers to weakness, numbness, or pain usually in your hands and feet, caused by damage to your peripheral nerves.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Nitrobest Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips for managing two common side effects:

Nausea: Follow the dietary recommendations provided by your doctor.
Diarrhoea: Consider drinking plenty of fluids to stay hydrated while taking this medication.

Nitrobest Tablet contains nitrofurantoin (100 mg), which acts on your body in the following way:

Concentration in Urine: After you take Nitrobest Tablet, nitrofurantoin is absorbed and gets concentrated in your urine.
Bacterial Disruption: In the urinary tract, nitrofurantoin is transformed by bacterial enzymes into reactive intermediates that disrupt important biochemical processes within the bacterial cells.
Bactericidal Effect: This disruption of bacterial cell processes makes nitrofurantoin lethal to bacteria at therapeutic doses in urine, effectively managing your UTI.

Remember, always consult your doctor before starting any new medication and discuss potential side effects or interactions with other medicines you might be taking.

Pregnancy

Nitrobest Tablet is contraindicated during the last few weeks of pregnancy (38-42 weeks gestation), during labour and delivery due to the risk of causing haemolytic anaemia in the neonate. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Nitrobest Tablet is excreted in breast milk. If you are breastfeeding, especially infants under 1 month old or those with G6PD deficiency, it is recommended to use an alternate feeding method while taking this medicine. Consult your doctor to understand the potential risks and benefits.

Alcohol

While on Nitrobest Tablet therapy, it is advised to avoid alcohol consumption. Alcohol may enhance certain side effects of the medication.

Liver

Caution is advised while taking Nitrobest Tablet if you have a history of liver problems such as cholestatic jaundice or hepatic dysfunction. It's best to discuss these concerns with your doctor before starting this medication.

Kidney

Nitrobest Tablet is contraindicated in patients with severe renal impairment like anuria, severe oliguria, or significant renal impairment (CrCl<60 mL/min). If you have kidney health issues, it's advisable to consult your doctor before starting this medicine.

Using Machines & Driving

No specific precautions are required for using machines or driving while on Nitrobest Tablet therapy. However, as dizziness is a possible side effect of this medication, caution should be exercised.

Allergy

This medicine is contraindicated if you have a known hypersensitivity to nitrofurantoin. If you have any known allergies, discuss them with your doctor before starting Nitrobest Tablet.

Children

Nitrobest Tablet should not be used in infants less than 1 month of age due to the risk of haemolytic anaemia. For older infants and children, the dose is adjusted based on their body weight.

Older Patients

Older patients should use Nitrobest Tablet with caution, as they may be more susceptible to its side effects and might have liver or kidney issues. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Nitrobest Tablet interacts with the following medicines:

Antacids: Medicines containing magnesium trisilicate may decrease the absorption of Nitrobest Tablet, reducing its effectiveness.
Uricosuric agents: Medications such as probenecid and sulfinpyrazone, used to manage gout, can reduce the antibacterial efficacy of Nitrobest Tablet.
Quinolone antibiotics: Antibiotics like ciprofloxacin and levofloxacin might interfere with the action of Nitrobest Tablet.

Drug-Food Interactions

Food high in calcium, like milk or cheese, can decrease the absorption of Nitrobest Tablet.

Drug-Disease Interactions

Nitrobest Tablet interacts with the following diseases:

Renal Impairment: People suffering from severe renal issues, including anuria and oliguria, should avoid taking Nitrobest Tablet as it could worsen their condition.
Liver Disease: Patients with a history of nitrofurantoin-induced cholestatic jaundice or hepatic dysfunction should not take this medication due to potential harm to their liver.
Glucose-6-phosphate dehydrogenase (G6PD) Deficiency: This medicine may cause hemolytic anaemia in patients deficient in G6PD. Do consult your doctor if you have this condition.

Daily Dose

You should take Nitrobest Tablet as and when prescribed by your doctor. This dosage can vary depending on factors such as the severity of your condition and your body's response to the medicine. Always stick to the dosage recommended by your doctor and do not increase it without his or her advice.

Over Dose

If you accidentally take more Nitrobest Tablets than prescribed, you might experience common side effects like nausea, vomiting, diarrhoea, loss of appetite, headache, dizziness, or a brown discolouration of the urine. If these symptoms persist or worsen, it's important to let your doctor know.

Missed Dose

If you forget to take a dose of Nitrobest Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never take an extra dose to make up for a missed one without consulting your doctor.

Store your Nitrobest Tablet in a cool, dry place where the temperature stays between 30°C.
Keep it away from direct sunlight and moisture.
Ensure it is out of reach and sight of children.
Always check the expiry date before using the medicine.

Stay well hydrated: Drinking plenty of water can help flush bacteria out of your urinary system, which may assist in managing your urinary tract infections (UTIs).
Regularly empty your bladder: Try not to hold urine for long periods as it can allow bacteria to multiply. Encouraging frequent urination can help manage UTIs effectively.

Fact Box

Drug Category	Bactericidal Antibiotic
Therapeutic Category	Antimicrobial
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Urinary Tract Infections, Cystitis

What is Nitrobest Tablet used for?

Nitrobest Tablet is used to manage and prevent certain urinary tract infections (UTIs) caused by specific types of bacteria.

How does Nitrobest Tablet manage UTIs?

The active ingredient, nitrofurantoin, disrupts vital processes in bacterial cells present in the urinary tract, effectively managing the infection.

Can Nitrobest Tablet be used for kidney infections or abscesses?

No, Nitrobest Tablet is not indicated for managing kidney infections or perinephric abscesses. Consult your doctor for suitable alternatives.

How should Nitrobest Tablet be taken?

You must take the medicine exactly as prescribed by your doctor.

What are some common side effects of Nitrobest Tablet?

Common side effects include nausea, vomiting, diarrhoea, loss of appetite, headache, dizziness, and brown discolouration of urine.

Can I take antacids while on Nitrobest Tablet?

Antacids containing magnesium trisilicate can decrease the absorption of nitrofurantoin. Consult your doctor before taking any other medicines.

Is Nitrobest Tablet safe for pregnant women and nursing mothers?

Avoid Nitrobest Tablet during late pregnancy and labour. Nursing mothers should use an alternate feeding method due to excretion in breast milk.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Kalpataru Inspire, 3rd Floor, Off. Western Express Highway, Santacruz (East), Mumbai

Country of origin: INDIA

References

Macrobid (Nitrofurantoin Capsules, USP) (monohydrate/macrocrystals). (n.d.). [Book]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/020064Orig1s029lbl.pdf
DailyMed - MACROBID- nitrofurantoin monohydrate and nitrofurantoin, macrocrystalline capsule. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1971e893-5fdb-41e3-a1e9-5e52deed03d1
Nitrofurantoin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00698
Nitrofurantoin: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a682291.html

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