Nuxvelar 400 Tablet 10

Nicholas Healthcare Limited

Strip of 10 Units

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MRP ~~₹230.00~~

₹114.77

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Composition

Sevelamer (400 Mg)

Nuxvelar 400 Tablet 10 is used to manage high blood phosphate levels, also known as hyperphosphatemia, in adults with chronic kidney disease who are on dialysis. It is a polymeric phosphate binder and a prescribed medication.

This medicine also plays a crucial role in maintaining strong bones and reducing harmful mineral accumulation in the body. By managing hyperphosphatemia, it may help decrease the risk of heart diseases and strokes, which are associated conditions.

You should take this medicine orally as directed by your doctor. Before starting this medication, share your medical history and ongoing treatments with your doctor. For optimal results, continue taking this tablet for the duration your doctor prescribes.

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Nuxvelar 400 Tablet 10 is used for the following:

Controlling high phosphate levels in the blood in adults with chronic kidney disease undergoing dialysis
Helping to maintain strong bones by reducing phosphate build-up
Lowering the risk of heart disease and stroke associated with elevated phosphate levels
Managing hyperphosphatemia (excessive phosphate in the blood) in patients receiving hemodialysis

Directions for Use of Nuxvelar 400 Tablet 10

Follow these instructions while taking Nuxvelar 400 Tablet 10:

Swallow the tablet whole with a glass of water during meals.
Do not crush, chew, split, or break the tablet.
Check the expiry date of the medicine before taking it.
Always consult your doctor before changing your dose or stopping the medicine.

Nuxvelar 400 Tablet 10 is taken orally.

While taking Nuxvelar 400 Tablet 10, you may experience the following common side effects:

Vomiting
Nausea
Diarrhoea
Constipation
Abdominal pain
Indigestion
Flatulence in stomach

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Nuxvelar 400 Tablet 10. However, if you experience any serious side effects or worsening symptoms, please consult your doctor.

Here are some tips to help manage two of these common side effects:

Nausea: Try taking Nuxvelar 400 Tablet 10 with food or milk to help reduce feelings of nausea.
Dyspepsia: If you are feeling discomfort in your stomach after taking this medicine, consider taking it after meals to lessen this effect.

Nuxvelar 400 Tablet 10 contains sevelamer (400 mg) that functions in the body as follows:

Phosphate binding: Sevelamer binds dietary phosphate in the gastrointestinal tract, preventing its absorption into the bloodstream. This action subsequently reduces blood phosphate levels.
Cholesterol reduction: Apart from controlling phosphate levels, sevelamer also reduces serum LDL cholesterol and total cholesterol levels.

Pregnancy

Caution is advised while taking Nuxvelar 400 Tablet 10 if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

The safety of Nuxvelar 400 Tablet 10 in nursing mothers has not been established. It's advisable to discuss this with your doctor before using this medicine while breastfeeding.

Alcohol

There's no specific information about any interaction between Nuxvelar 400 Tablet 10 and alcohol. However, it's always wise to seek your doctor's advice before consuming alcohol while on medication.

Liver

Nuxvelar 400 Tablet 10 is primarily used in patients with kidney disease, so there isn't much data about its effects on liver health. If you have liver problems, it would be wise to discuss them with your doctor before starting this medication.

Kidney

Nuxvelar 400 Tablet 10 is used to manage high phosphate levels in patients with chronic kidney disease, so it is essential for patients with renal issues. However, always consult your doctor before starting any new medication.

Using Machines & Driving

No specific information suggests that Nuxvelar 400 Tablet 10 would affect the ability to operate machinery or drive. However, if you feel unwell or experience side effects, choose not to engage in such activities and consult your doctor.

Allergy

If you are allergic to sevelamer or any other ingredients in Nuxvelar 400 Tablet 10, avoid using this medicine. Always inform your doctor about your allergies before starting a new medication.

Children

The safety and efficacy of Nuxvelar 400 Tablet 10 in children have not been established. Therefore, it's recommended not to give this medicine to children under 18 without consulting a doctor.

Older Patients

Older patients should take Nuxvelar 400 Tablet 10 under medical supervision. They may be more prone to its side effects and might have liver and kidney issues. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Nuxvelar 400 Tablet 10 interacts with the following medicines:

Antibiotics: Medications like ciprofloxacin may reduce absorption when taken alongside Nuxvelar 400 Tablet 10, potentially weakening their effects.
Cardiac medicines: Specific medicines such as digoxin and metoprolol may interact with Nuxvelar 400 Tablet 10, decreasing their bioavailability and effectiveness.
Blood pressure regulators: Medicines such as enalapril could have reduced bioavailability due to interactions with Nuxvelar 400 Tablet 10.
Anticoagulants: The absorption of anticoagulants like warfarin may be affected when taken with Nuxvelar 400 Tablet 10, possibly altering their therapeutic effects.

Drug-Food Interactions

No specific food interactions have been reported for Nuxvelar 400 Tablet 10.

Drug-Disease Interactions

Nuxvelar 400 Tablet 10 interacts with the following diseases:

Gastrointestinal disorders: Patients suffering from severe gastrointestinal motility issues or with a history of major gastrointestinal tract surgery should exercise caution when taking Nuxvelar 400 Tablet 10.

Daily Dose

The daily dose of Nuxvelar 400 Tablet 10 should be taken as instructed by your doctor. This dosage might vary depending on your health situation and how your body reacts to the medicine. Always follow the dosage prescribed by your doctor and never increase it without their guidance. For comprehensive information, refer to the package insert.

Over Dose

Taking too much of any medicine can be harmful. If you accidentally take an extra dose of Nuxvelar 400 Tablet 10, you may experience more severe versions of the common side effects such as nausea or stomach upset. If this happens, let your doctor know.

Missed Dose

If you forget to take a dose of Nuxvelar 400 Tablet 10, take it as soon as you recall. But if it's nearly time for your next dose, skip the missed one and continue your normal schedule. Never double up on doses without consulting your doctor.

Store Nuxvelar 400 Tablet 10 in a cool, dry place. The ideal storage temperature is room temperature below 30°C.
Protect the tablet from heat and moisture.
Keep it out of reach and sight of children.
Always use the tablet before its expiry date.

Monitor your dietary phosphate intake. As Nuxvelar 400 Tablet 10 manages high blood phosphate levels, reducing your intake of phosphate-rich foods such as dairy products, whole grains, and organ meats can assist in managing your condition.
Maintain a heart-healthy lifestyle. Regular exercise and a diet low in saturated fats can help reduce your risk of heart disease and stroke, which are often associated with chronic kidney disease.

Fact Box

Drug Category	Phosphate Binder
Therapeutic Category	Hyperphosphatemia Management
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Kidney Disease, Hyperphosphatemia

What is the purpose of Nuxvelar 400 Tablet 10?

This medicine is used to manage high levels of phosphate in the blood in adults with chronic kidney disease on dialysis.

How does the Nuxvelar 400 Tablet 10 work?

It contains sevelamer, which binds dietary phosphate in the gut, preventing its absorption and thereby reducing blood phosphate levels.

Can I crush or chew the Nuxvelar 400 Tablet 10?

No, these tablets should be swallowed whole. Crushing, chewing, or breaking them can affect how they work.

What are the possible side effects of Nuxvelar 400 Tablet 10?

Common side effects include vomiting, nausea, diarrhoea, stomach discomfort, abdominal pain, wind, and constipation. Consult your doctor if symptoms persist or worsen.

Can I take other medicines with Nuxvelar 400 Tablet 10?

Sevelamer may reduce the effect of certain medicines. Always consult your doctor before taking this tablet with other medicines.

How should I store the Nuxvelar 400 Tablet 10?

Store it at room temperature below 30°C, protect it from moisture and heat, and keep it out of children's reach.

How should I take Nuxvelar 400 Tablet 10?

It should be taken orally with meals or as directed by your doctor.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Divya Chauhan

Medical Writer & Reviewer | 6 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

503/504 Hubtown solaris, Andheri (E), Mumbai 400069 INDIA

Country of origin: INDIA

References

MedlinePlus. (2022, February 23). Sevelamer Carbonate. U.S. National Library of Medicine. Retrieved April 1, 2024, from https://medlineplus.gov/druginfo/meds/a601248.html
U.S. Food and Drug Administration. (2007). Label: Sevelamer carbonate tablet, film-coated. Retrieved April 1, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021179s021lbl.pdf
Sevelamer. (n.d.). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB00658
PubChem. (n.d.). Sevelamer. https://pubchem.ncbi.nlm.nih.gov/compound/Sevelamer
Sevelamer carbonate 800 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc). (n.d.). https://www.medicines.org.uk/emc/product/8784/smpc

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