Odensomab 60mg Injection 1

Lupin Ltd

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Composition

Denosumab (60 Mg)

Odensomab Injection is a prescription medicine primarily used to manage bone-related conditions. It is part of a group of medicines called monoclonal antibodies.

In addition to its main use, this medicine may also be used to manage other conditions. These include osteoporosis in postmenopausal women and men at high risk of fractures, bone loss due to certain cancer treatments, slowing down the growth of giant cell tumours, and managing high blood calcium levels associated with cancer.

It's important to administer this medicine exactly as directed by your doctor. Before starting the medicine, let your doctor know about any pre-existing conditions or ongoing medicines. If you experience any side effects, inform your doctor right away. For the best results, continue administering the medication for the duration prescribed by your doctor.

Odensomab Injection is used for the following:

Managing osteoporosis in postmenopausal women and men at high risk of fractures
Preventing bone loss in cancer patients undergoing certain treatments
Slowing down the growth of non-cancerous bone tumours known as giant cell tumours
Controlling high blood calcium levels associated with certain types of cancer

Directions for Use of Odensomab 60mg Injection 1

Administer Odensomab Injection as follows:

A healthcare professional should administer the injection.
Do not try to self-administer this medicine.
Always keep your appointments to ensure you receive your injections at regular intervals.
Specific advice on the dosing schedule should be sought from your doctor.

Odensomab Injection is administered subcutaneously (under your skin).

Side Effects of Odensomab 60mg Injection 1

While using Odensomab Injection, you may experience the following side effects:

Back, joint, or muscle pain
Pain in the arms or legs
Constipation
Urinary tract infections
High cholesterol levels: This means the amount of cholesterol in your blood could increase.
Osteonecrosis of the jaw (ONJ): A rare but serious condition causing damage to the jawbone, typically after dental procedures.
Hypocalcemia: This is a condition where there are lower than normal levels of calcium in your blood, leading to symptoms like muscle spasms and tingling sensations.
Serious infections: While rare, this medicine may increase your risk of developing infections.

Managing the Side Effects:

Most side effects are temporary and generally harmless, and resolve on discontinuing Odensomab Injection. However, if you experience any serious side effects or worsening symptoms, please consult your doctor.

Here are some tips to manage certain side effects:

Back, joint, or muscle pain: Taking this injection at night might be helpful if it causes you pain during the day.
Constipation: Consider taking this medicine with meals to help lessen this effect.

Odensomab Injection contains denosumab (60 mg), which works on your body as follows:

RANK Ligand Inhibition: Denosumab targets and binds to a protein in your body called RANK ligand. This protein plays a key role in the breakdown of your bones.
Decreases Bone Resorption: By inhibiting RANK ligand, denosumab reduces the formation and activity of cells called osteoclasts, which are responsible for breaking down bone tissue. This effect leads to decreased bone resorption, thereby increasing bone mass and strength.

Pregnancy

Odensomab Injection is not recommended during pregnancy. If you are pregnant or planning to become pregnant, make sure to discuss this with your doctor before starting on this medication.

Breastfeeding

Breastfeeding while receiving Odensomab Injection is not advised. Consult your doctor to understand the potential risks and benefits.

Alcohol

There is no specific restriction on alcohol consumption with Odensomab Injection, but it's always wise to check with your doctor.

Liver

Caution is advised if you have liver-related issues while using Odensomab Injection. It is best to consult your doctor before using this medicine.

Kidney

If you have kidney health problems, it's prudent to discuss this with your doctor before starting Odensomab Injection. This medicine might affect kidney function.

Using Machines & Driving

Odensomab Injection does not usually interfere with the ability to drive or operate machinery, but it's always safe to confirm with your doctor.

Allergy

If you are allergic to denosumab or any other components of Odensomab Injection, inform your doctor.

Children

Odensomab Injection is intended for adult use only. Giving this medication to children under 18 years of age is not recommended without medical supervision.

Older Patients

Older patients should use Odensomab Injection under medical supervision, as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Interactions of Odensomab 60mg Injection 1

Drug-Drug Interactions

Odensomab Injection interacts with the following medicines:

Calcium Supplements and Antacids Containing Calcium: These medicines can affect the blood calcium levels, which are important to monitor when taking Odensomab Injection. Examples include calcium carbonate and calcium citrate.
Vitamin D Supplements: Vitamin D aids in the absorption of calcium; thus, interactions with these supplements may impact the effectiveness of Odensomab Injection. Specific supplements include cholecalciferol and ergocalciferol.
Corticosteroids: Medicines like prednisone and dexamethasone can potentially increase the risk of hypocalcemia (low blood calcium levels) when taken alongside Odensomab Injection.
Immunosuppressants: These medications, such as cyclosporine and tacrolimus, may increase the risk of infections, a potential side effect of Odensomab Injection.

Drug-Food Interactions

Drug-Disease Interactions

Odensomab Injection interacts with the following diseases:

Hypocalcemia: Individuals with low blood calcium levels need to correct this condition before starting Odensomab Injection, as it can further lower these levels.
Kidney Impairment: People with kidney problems should be cautious as they are more likely to develop hypocalcemia during treatment with Odensomab Injection.

Daily Dose

Your daily dose of Odensomab Injection should be administered as prescribed by your doctor. The dosage may vary depending on factors like the severity of your condition and how you respond to the medicine. It is crucial to follow your doctor's instructions and not alter the dose without consulting them.

Over Dose

If you accidentally receive more than the prescribed dose of Odensomab Injection, you might experience some common side effects in a more intense form, such as back or muscle pain, constipation, or urinary tract infections. If these symptoms persist or worsen, do inform your doctor.

Missed Dose

If you forget to administer your scheduled dose of Odensomab Injection, have it as soon as you remember. But if it's nearly time for your next dose, skip the missed one and return to your regular schedule. Never double up on doses without consulting your doctor.

Store Odensomab Injection in a refrigerator, maintaining a temperature between 2°C to 8°C.
Avoid freezing or shaking the injection.
Keep it away from direct sunlight and moisture.
Always keep the medicine out of reach of children.
Make sure you use the product before its expiry date.

As Odensomab Injection is used to manage osteoporosis, ensure you consume a diet rich in calcium and vitamin D. These nutrients help support bone health. Foods such as dairy products, leafy green vegetables, and fortified foods can be beneficial.
Regular weight-bearing exercises, such as walking or gentle weight training, can help strengthen bones and reduce the risk of fractures associated with osteoporosis. Always consult your doctor before starting any new exercise regimen.

Fact Box

Drug Category	Monoclonal Antibody
Therapeutic Category	Bone Health Medication
Available Dosage Types	Injection
Habit Forming	No
Ailment	Osteoporosis, Bone Loss Due to Cancer Treatment, Giant Cell Tumour of Bone

What is Odensomab Injection used for?

Odensomab Injection is used to manage various bone-related conditions such as osteoporosis, bone loss due to cancer treatment, giant cell tumours, and high blood calcium levels.

How does Odensomab Injection work?

The active ingredient in Odensomab Injection, denosumab, targets a protein called RANK ligand. It reduces the breakdown of bone tissue, strengthening bones and reducing fracture risk.

Can I self-administer Odensomab Injection?

No. Odensomab Injection should be administered by a doctor. Do not try to administer this medicine yourself.

What are the common side effects of Odensomab Injection?

Common side effects include back, joint or muscle pain, pain in limbs, constipation, urinary tract infections and high cholesterol levels.

Is it safe to use Odensomab Injection during pregnancy?

No. Pregnant women should avoid using Odensomab Injection as it may harm the developing fetus.

Can I take calcium and vitamin D supplements while receiving Odensomab Injection?

Yes, your doctor may recommend these supplements to help maintain healthy blood calcium levels during treatment.

Can I receive Odensomab Injection if I have dental implants?

Yes, but informing your dentist about your treatment and maintaining good oral hygiene is essential to minimise the risk of jawbone tissue death.

Last Updated On 25 Apr. 2025 | 5:11AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

Kalpataru Inspire, 3rd Floor, Off. Western Express Highway, Santacruz (East), Mumbai

Country of origin: INDIA

References

MedlinePlus. (n.d.). Denosumab Injection. https://medlineplus.gov/druginfo/meds/a610023.html. Accessed 1 April 2024.
U.S. Food and Drug Administration. (2011). FDA label. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125320s5s6lbl.pdf. Accessed 1 April 2024.
Denosumab - StatPearls - NCBI bookshelf. (2022, February 24). National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK535388/
DrugBank. (2025, March 6). Denosumab. https://go.drugbank.com/drugs/DB06643

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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