Parihep 40 Mg Injection 1

Parihep 40 Injection 0.4ml

Abbott India Ltd.

Pre-filled syringe of 0.4 ML

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MRP ~~₹470.27~~

₹385.62

₹1175.68/ML

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Composition

Enoxaparin (40 Mg)

Parihep 40 Injection 0.4ml is primarily used for the management of venous thromboembolism and other conditions involving blood clot formation. It is part of a group of medicines known as low molecular weight heparin (LMWH) anticoagulants.

It plays a crucial role in preventing other conditions like deep vein thrombosis (DVT) and pulmonary embolism (PE). Furthermore, it helps manage unstable angina and non-Q-wave myocardial infarction (NSTEMI) when used concurrently with aspirin. It is also beneficial in managing acute ST-segment elevation myocardial infarction (STEMI), including patients who are being medically managed or those undergoing subsequent percutaneous coronary intervention (PCI).

You must always consult your doctor for the correct dosage and frequency. It is essential to notify your doctor about any pre-existing diseases or ongoing medications before you start using this medicine. If you notice any side effects while on this medicine, alert your doctor immediately.

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Parihep 40 Injection 0.4ml is used for the following conditions:

Preventing deep vein thrombosis (DVT), a condition where blood clots form in the deeper veins of your body, usually in the legs
Managing pulmonary embolism (PE), which occurs when a blood clot gets lodged in an artery in the lung, blocking blood supply to lung tissue
Reducing the risk of unstable angina, which can cause chest pain and discomfort due to reduced blood flow to the heart
Addressing non-Q-wave myocardial infarction (NSTEMI), where part of the heart muscle has died due to insufficient blood supply
Managing acute ST-segment elevation myocardial infarction (STEMI), a severe type of heart attack caused by prolonged blockage of blood supply in the heart

Directions for Use of Parihep 40 Injection 0.4ml

Parihep 40 Injection 0.4ml is administered by a healthcare professional.
Ensure that the the site of injection area is clean and dry.
This medicine is injected under the skin (subcutaneously) or into the veins (intravenously) as directed by your doctor.

Parihep 40 Injection 0.4ml is administered subcutaneously or intravenously by a healthcare professional.

Side Effects of Parihep 40 Injection 0.4ml

Parihep 40 Injection 0.4ml may have the following common side effects:

Local injection site reactions: These may include symptoms like a small blood clot under the skin, pain, or bruising at the place where you had the injection.
Thrombocytopenia: It means a decrease in the number of platelets in your blood, which are essential for clot formation.
Elevations of serum aminotransferases: This can indicate damage or inflammation in your liver.

Managing the Side Effects:

Most common side effects are temporary and generally harmless, which resolve on discontinuing the use of Parihep 40 Injection 0.4ml. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general suggestions for managing common side effects:

Thrombocytopenia: If you notice unusual bruising or bleeding, try to avoid activities that could lead to injury.
Local injection site reactions: Apply a clean, cool wet cloth to your skin at the injection site to help soothe any discomfort or swelling.

Parihep 40 Injection 0.4ml contains enoxaparin (40 mg), which works on your body in the following ways:

Enhances Inhibition of Factor Xa and Thrombin: Enoxaparin boosts the inhibition of factor Xa and thrombin by antithrombin III. These factors are involved in blood coagulation, so inhibiting them helps prevent blood clots.
Interrupts Blood Coagulation Cascade: By enhancing the inhibition of factor Xa and thrombin, enoxaparin interrupts the blood coagulation cascade, thus preventing the formation of blood clots.

Pregnancy

If you are pregnant, caution is advised while taking Parihep 40 Injection 0.4ml. Consult your doctor for appropriate advice.

Breastfeeding

Since it's uncertain if enoxaparin is excreted in human milk, it is essential to inform the doctor about the same before taking this injection.

Alcohol

Caution is advised when consuming alcohol if this injection is prescribed to you to avoid any adverse effects.

Liver

If you have liver health issues, it's advisable to consult your doctor before using Parihep 40 Injection 0.4ml. Your doctor will guide you based on your health status.

Kidney

In case of kidney health issues, particularly severe renal impairment, dosage adjustment may be necessary for Parihep 40 Injection 0.4ml. Consultation with your doctor prior to starting this medication is a good idea.

Using Machines & Driving

Parihep 40 Injection 0.4ml's effect on the ability to drive or operate heavy machinery has not been studied. Nevertheless, it's crucial to be aware of how this medicine affects you before engaging in such activities.

Allergy

This medicine should not be used if you're allergic to enoxaparin, heparin, or pork products. If you have a history of allergies, make sure to discuss this with your doctor before starting Parihep 40 Injection 0.4ml.

Children

The safety and efficacy of Parihep 40 Injection 0.4ml in children have not been established. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Parihep 40 Injection 0.4ml under medical supervision as they may be more susceptible to its side effects. Caution is advised for patients above 70 years of age who might also have liver and kidney issues. Your doctor will guide you based on your health status.

Interactions of Parihep 40 Injection 0.4ml

Drug-Drug Interactions

Parihep 40 Injection 0.4ml interacts with the following medicines:

Anticoagulants: Medicines such as warfarin can interact with Parihep 40 Injection 0.4ml and increase the risk of bleeding.
Thrombolytic Agents: Medicines like alteplase can interact with Parihep 40 Injection 0.4ml, escalating the risk of bleeding.
Non-Steroidal Anti-Inflammatory Medicines (NSAIDs): Medicines such as ibuprofen or naproxen may interact with Parihep 40 Injection 0.4ml, potentially heightening the risk of bleeding.

Drug-Food Interactions

Parihep 40 Injection 0.4ml does not have any known interactions with food.

Drug-Disease Interactions

Parihep 40 Injection 0.4ml interacts with the following diseases:

Active Major Bleeding: Parihep 40 Injection 0.4ml can worsen this condition due to its anticoagulant effect.
History of Heparin-induced Thrombocytopenia (HIT): This medicine should not be used if you have a history of HIT as it could lead to similar reactions.

Daily Dose

The recommended dose for Parihep 40 Injection 0.4ml is decided by your healthcare professional. For further details regarding dosage instructions, please refer to the package insert.

Over Dose

Overdose of this injection is unlikely as it is administered by a healthcare professional.

Missed Dose

Parihep 40 Injection 0.4ml is administered subcutaneously or intravenously by a healthcare professional. In case a dose is missed, inform your doctor immediately.

Store Parihep 40 Injection 0.4ml at room temperature, store below 25°C.
Keep it away from direct light, heat, and moisture.
Always place it in a secure place out of children's reach.
Use the content within 28 days after the first use.

Eat a heart-friendly diet which includes foods low in saturated fats and high in fibre, such as fruits, vegetables, and whole grains. Also, try to limit your salt intake to manage blood pressure.
Regular physical activity can help maintain healthy blood flow and reduce the risk of blood clots. Try to incorporate moderate exercise into your daily routine, but remember to consult your doctor about what's safe for you before starting any new exercise regimen.

Fact Box

Drug Category	Anticoagulant
Therapeutic Category	Low Molecular Weight Heparin
Available Dosage Types	Injection
Habit Forming	No
Ailment	Deep Vein Thrombosis, Pulmonary Embolism, Unstable Angina

What is Parihep 40 Injection 0.4ml used for?

Parihep 40 Injection 0.4ml is used to manage conditions involving the formation of blood clots, such as deep vein thrombosis and pulmonary embolism.

How does Parihep 40 Injection 0.4ml work?

It works by enhancing the inhibition of blood clotting factors, thus preventing the formation and spread of blood clots in your body.

Can I take Parihep 40 Injection 0.4ml if I am allergic to pork?

No, if you're allergic to pork, you should not take this medicine as it may cause hypersensitivity reactions.

Can I administer a Parihep 40 Injection 0.4ml if I have severe renal impairment?

You should consult your doctor before administering this medicine; adjustments may be necessary for patients with severe renal impairment.

What are the common side effects of Parihep 40 Injection 0.4ml?

Common side effects can include minor bleeding, reduced platelet count, increased liver enzymes, and discomfort at the injection site.

Can I use other anticoagulants or antiplatelet agents while administering Parihep 40 Injection 0.4ml?

Consult your doctor before using other anticoagulants or antiplatelet agents, as it may increase your risk of bleeding.

Is it safe to use Parihep 40 Injection 0.4ml during pregnancy or while breastfeeding?

Consult your doctor before administering this medicine if you are pregnant or breastfeeding. It should be used only if clearly needed.

Certified Content

Written by

Dr Vatsalya D Ghanekar

Medical Content Writer | 5 years

MD Ayurveda

Reviewed by

Dr. Saniya K Mulla

Medical Writer & Reviewer | 5 years

MBBS

Check out Editorial Policy

Manufacturer details

3, Corporate Park, Sion Trombay Road, Mumbai - 400 071, India

Country of origin: INDIA

References

Research, C. F. D. E. A. (2018, February 6). Generic Enoxaparin questions and answers. U.S. Food And Drug Administration. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/generic-enoxaparin-questions-and-answers
Enoxaparin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01225
Enoxaparin Injection: MedlinePlus Drug Information. (n.d.). https://medlineplus.gov/druginfo/meds/a601210.html
Jupalli, A., & Iqbal, A. M. (2023, August 28). Enoxaparin. StatPearls - NCBI Bookshelf.https://www.ncbi.nlm.nih.gov/books/NBK539865/

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