Pirfenex 400 Mg Tablet 15

Pirfenex 400mg Tablet 15

Cipla Ltd.

Strip of 15 Units

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MRP ~~₹705.12~~

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Composition

Pirfenidone (400 Mg)

Strength:

400 MG 600 MG 200 MG

Pirfenex 400mg Tablet is primarily used to manage idiopathic pulmonary fibrosis (IPF) in adults. This medicine is a part of a group known as anti-fibrotic and anti-inflammatory medications.

This medicine also helps slow down the progression of IPF, a condition characterised by scar tissue build-up in the lungs, leading to breathing difficulties. However, it's important to note that while it assists in managing the disease, it does not provide a complete cure.

Before starting this medicine, you should consult your doctor who will guide you with the appropriate dosage and frequency. It's crucial to inform your doctor about any ongoing medications or any pre-existing medical conditions. If you notice any side effects while on this medicine, notify your doctor immediately. Also, it is essential to continue taking the medicine for the duration prescribed by your doctor for optimal results.

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Pirfenex 400mg Tablet is used for the following:

Management of mild to moderate idiopathic pulmonary fibrosis in adults
Slowing down the progression of idiopathic pulmonary fibrosis

Directions for Use of Pirfenex 400mg Tablet 15

Swallow the tablet whole with a glass of water.
Avoid crushing, chewing, or breaking the tablet.
If you forget a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one. Never take two doses at once.
Always consult your doctor before changing your dosage or stopping this medicine.

Pirfenex 400mg Tablet is taken orally.

Side Effects of Pirfenex 400mg Tablet 15

Pirfenex 400mg Tablet may have the following common side effects:

Nausea
Rash
Abdominal pain
Upper respiratory tract infection
Diarrhoea
Fatigue
Headache
Dyspepsia: This is indigestion, which can result in bloating or an uncomfortable feeling in the stomach.
Dizziness

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Pirfenex 400mg Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips to manage common side effects:

Nausea: Try to take Pirfenex 400mg Tablet with or after meals to help manage this symptom.
Dyspepsia: If you're experiencing indigestion, consider taking this medicine after meals to lessen this effect.

Pirfenex 400mg Tablet contains pirfenidone (400mg), which acts on the body in the following ways:

Inhibits TGF-β Synthesis: Pirfenidone works by blocking the production of a protein called transforming growth factor-beta (TGF-β). This protein is involved in the formation of scar tissue in the lungs.
Reduces Fibrosis and Inflammation: By inhibiting the synthesis of TGF-β, pirfenidone effectively reduces the development of fibrosis (scar tissue) and inflammation. This helps preserve lung function in patients with IPF.

Pregnancy

Caution is advised while taking Pirfenex 400mg Tablet if you are pregnant. It is preferable to avoid its use during pregnancy. Consult your doctor before starting this medicine.

Breastfeeding

A risk to newborns/infants cannot be excluded. Discuss with your doctor the benefits and risks of using this medicine while breastfeeding.

Alcohol

There's no interaction of Pirfenex 400mg Tablet with alcohol. However, it's always wise to consult your doctor for guidance.

Liver

Pirfenex 400mg Tablet should be used with caution if you have mild to moderate liver impairment, and is not recommended for severe liver diseases. Regular liver function tests may be necessary while using this medicine.

Kidney

No dose adjustment is required if you have mild to moderate kidney impairment. However, Pirfenex 400mg Tablet hasn't been studied in patients with severe kidney impairment or end-stage renal disease requiring dialysis. Consult your doctor before use.

Using Machines & Driving

If you experience side effects like dizziness, avoid such activities and discuss with your doctor.

Allergy

Pirfenex 400mg Tablet is contraindicated if you have known hypersensitivity to pirfenidone or any of the tablet excipients. If you have allergies, share this information with your doctor before starting this medicine.

Children

The safety and effectiveness of Pirfenex 400mg Tablet in children haven't been established yet. Always consult your doctor before giving any medicine to a child.

Older Patients

No differences in safety or effectiveness were observed between older and younger patients when using Pirfenex 400mg Tablet. No dose adjustment is required based solely on age. However, it is advisable to use this medicine under medical supervision due to potential liver and kidney issues in older patients.

Interactions of Pirfenex 400mg Tablet 15

Drug-Drug Interactions

Pirfenex 400mg Tablet interacts with the following medicines:

Antidepressants: Medications such as fluvoxamine can increase pirfenidone levels, raising the risk of side effects like nausea and dizziness.
Antibiotics: Medicines like rifampin may decrease pirfenidone levels, reducing its effectiveness in treating pulmonary fibrosis.
Oral corticosteroids: Concurrent use of methylprednisone may increase the risk of gastrointestinal side effects such as nausea or indigestion.

Drug-Food Interactions

Pirfenex 400mg Tablet should be taken with food to help absorption.

Drug-Disease Interactions

Pirfenex 400mg Tablet interacts with the following diseases:

Liver disease: People with liver disease should exercise caution as Pirfenex 400mg Tablet could worsen their condition.
Kidney disease: Pirfenex 400mg Tablet should be used with caution in patients with mild to moderate renal impairment. It has not been studied in patients with severe renal impairment or end-stage renal disease requiring dialysis.
Sun sensitivity: Pirfenidone, the active ingredient in Pirfenex 400mg Tablet, can cause photosensitivity reactions. Therefore, if you have a history of sun sensitivity, you should take extra precautions to avoid sun exposure while taking this medication.

Daily Dose

The daily dose of Pirfenex 400mg Tablet should be as directed by your doctor. The dosage can vary based on individual factors such as the severity of the condition and how well you respond to the medicine. Make sure you follow the prescribed dosage and do not exceed it without consulting your doctor.

Over Dose

If you've accidentally taken more Pirfenex 400mg Tablet than recommended, don't worry. You might feel a bit nauseous or have some stomach discomfort. If these symptoms persist or get worse, inform your doctor about it.

Missed Dose

If you missed a dose of Pirfenex 400mg Tablet, take it as soon as you remember. But if it's nearly time for your next dose, skip the one you missed and carry on with your regular schedule. Never double up on doses without checking with your doctor first.

Store Pirfenex 400mg Tablet at room temperature.
Keep it away from direct sunlight and moisture.
Ensure the bottle is tightly closed when not in use.
Keep it out of reach of children for safety.
Always remember to check the expiry date before use.

Avoid smoking: As you're managing idiopathic pulmonary fibrosis (IPF) with Pirfenex 400mg Tablet, it's crucial to stop smoking. Cigarette smoke can worsen your lung condition and may alter the effectiveness of this medicine.
Protect yourself from sun exposure: Pirfenidone, the active ingredient in this medicine, can cause photosensitivity reactions. So remember to wear protective clothing and apply sunscreen when outdoors.

Fact Box

Drug Category	Anti-fibrotic
Therapeutic Category	Anti-inflammatory
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Idiopathic Pulmonary Fibrosis

What is Pirfenex 400mg Tablet used for?

This medicine is used to manage idiopathic pulmonary fibrosis (IPF), a lung condition causing difficulties in breathing due to scar tissue formation.

How should I take Pirfenex 400mg Tablet?

You must take the medicine as directed by your doctor.

What are the common side effects of Pirfenex 400mg Tablet?

Common side effects include nausea, skin rash, stomach pain, upper respiratory tract infection, diarrhoea, fatigue, headache, and dizziness.

Can I take Pirfenex 400mg Tablet if I have liver issues?

If you have mild to moderate liver impairment, use this medicine cautiously. It's not recommended for severe liver impairment. Always consult your doctor.

Should I avoid sunlight while taking Pirfenex 400mg Tablet?

Yes, because pirfenidone can cause photosensitivity reactions. So avoid sun exposure and wear protective clothing and sunscreen when outdoors.

Can pregnant or breastfeeding women take Pirfenex 400mg Tablet?

The effects of this medicine on pregnant or breastfeeding women are unclear, so it's best to consult your doctor before using it.

Is Pirfenex 400mg Tablet safe for children and elderly individuals?

The safety and efficacy of this medicine have not been established in children. For elderly individuals, there's no need for dose adjustment based solely on age.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: INDIA

References

InterMune. (2014). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022535s000lbl.pdf
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS. (n.d.). https://www.ema.europa.eu/en/documents/product-information/esbriet-epar-product-information_en.pdf
Sandoz Canada Inc. (2020). SANDOZ PIRFENIDONE TABLETS. In SANDOZ PIRFENIDONE TABLETS (pp. 1–42) [Product monograph]. https://pdf.hres.ca/dpd_pm/00060877.PDF
Pirfenidone: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB04951
PubChem. (n.d.). Pirfenidone. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Pirfenidone

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