Polyxx Injection 1

Polyxx Injection 1 is commonly used for managing:

• Severe urinary tract infections caused by Escherichia coli

• Meningitis and other brain infections

• Serious bloodstream infections, also known as bacteremia

• Certain eye infections

To ensure the correct use of Polyxx Injection 1, follow these key steps:

• This medicine should only be administered by qualified healthcare personnel.

• The injection can be given into a vein (intravenous), a muscle (intramuscular), into the spinal canal (intrathecal), or ophthalmic (topical and subconjunctivally), depending on the infection being managed.

• Under all circumstances, consult your doctor for specific advice about using this medication.

Polyxx Injection 1 can be administered through various methods, including intravenous, intramuscular, ophthalmic (topical and subconjunctival), or directly into the spinal canal.

Polyxx Injection 1 contains a single potent active ingredient, Polymyxin B Sulphate (500000 IU), which exerts its effects in the following ways:

• Disruption of Bacterial Cell Membrane: Polymyxin B interacts with the outer membrane of gram-negative bacteria. It attaches to negatively charged lipids and phospholipids in the bacterial cell membrane, displacing calcium and magnesium bridges that stabilise these molecules.

• Leakage of Bacterial Contents: After interacting with the bacterial cell membrane, Polymyxin B inserts itself into it, making the membrane permeable. This action causes leakage of the contents within the bacterial cell leading to cell death.

• Detoxification: An additional effect of Polymyxin B is its ability to neutralise toxins released by lysed bacteria providing a detoxifying effect on your body.

• Before reconstitution, store at room temperature (15-30°C), protected from light.

• Reconstituted solutions should be stored under refrigeration (2-8°C), and the unused portion should be discarded after 24 hours (for intravenous, intramuscular, intrathecal, and subconjunctival applications).

• Reconstituted solutions should be stored under refrigeration (2-8°C). Any unused portion should be discarded after 72 hours (for topical ophthalmic applications).

• Always keep this medicine out of reach of children.

• Ensure you use the injection before its expiry date.

• If you're managing a urinary tract infection with Polyxx Injection 1, increase your water intake. Staying well-hydrated helps flush bacteria out of your urinary system.

• For those managing meningitis or other brain infections, make sure to get plenty of rest. This helps your body fight off the infection more effectively.