Powercef S 375 Mg Injection 1

Powercef S 375mg Injection 1

Dr. Reddys Laboratories Ltd

Vial of 1 UNITS

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MRP ~~₹152.5~~

₹125.05

₹152.50/UNITS

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Prescription required for this medicine

Store in refrigerator or (2^o - 8^o C) Do Not Freeze

Composition

Ceftriaxone (250 Mg) + Sulbactam (125 Mg)

Powercef S 375mg Injection 1 is primarily used to manage a variety of bacterial infections in different parts of the body. It's a combination medicine belonging to the class of third-generation cephalosporin antibiotics.

This injection is also used to manage ear, nose and throat infections; respiratory tract infections like pneumonia; urinary tract infections (UTI); skin and soft tissue infections; bone and joint infections; intra-abdominal infections; meningitis; and septicaemia (blood infection). It is also used for surgical prophylaxis.

Before starting this injection, it's important to inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects while on this medication, notify your doctor immediately. For optimal results, you should continue taking the injection for the duration prescribed by your doctor.

Powercef S 375mg Injection 1 is used for managing the following conditions:

Ear, nose and throat infections
Respiratory tract infections such as pneumonia
Urinary tract infections
Skin and soft tissue infections
Joint and bone infections
Infections within the abdomen
Meningitis
Septicaemia
Preventing pre or post-operative infections

Directions for Use of Powercef S 375mg Injection 1

This medicine should be administered by a healthcare professional only.
It is given either as a slow intravenous infusion over 15-30 minutes or as a deep intramuscular injection.
Do not mix this medicine with other antimicrobial medications.

Powercef S 375mg Injection 1 is administered intravenously or via an intramuscular route.

Side Effects of Powercef S 375mg Injection 1

While taking Powercef S 375mg Injection 1, you may experience the following common side effects:

Skin rashes and pain at the injection site
Diarrhoea
Nausea
Vomiting
Inflammation in the mouth and lips
Inflammation of the tongue
Eosinophilia: Higher than normal level of eosinophils
Exanthema: Skin rash
Allergic Dermatitis: Itchy, red skin rash developed due to allergic reaction

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Powercef S 375mg Injection 1. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of tips to manage common side effects:

Diarrhoea: Consider taking Powercef S 375mg Injection 1 with food or milk.
Nausea: To minimise this effect, you may want to take this injection after meals.

Powercef S 375mg Injection 1 contains two active ingredients:

Ceftriaxone (250 mg): As a third-generation cephalosporin antibiotic, ceftriaxone works by inhibiting the formation of bacterial cell walls. It attaches itself to specific proteins within the bacterial cell wall and disrupts the process of peptidoglycan synthesis – an essential step in cell wall creation. This disruption leads to cell lysis or breakdown, resulting in bacterial death.
Sulbactam (125 mg): It is a beta-lactamase inhibitor that nullifies the effect of beta-lactamase enzymes produced by some bacteria. These enzymes can degrade antibiotics like ceftriaxone, making them ineffective. By binding with these enzymes and inhibiting their action, sulbactam protects ceftriaxone from degradation. This extends ceftriaxone's effectiveness in containing bacteria that produce beta-lactamase and would otherwise be resistant.

Pregnancy

Caution is advised while taking Powercef S 375mg Injection 1 if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

The contents of this injection are likely to get excreted in human milk. Caution should be exercised when this injection is administered to a nursing woman.

Alcohol

It is advised to avoid the consumption of alcohol if you are getting this injection administered to avoid any adverse effects.

Liver

Powercef S 375mg Injection 1 may affect liver function tests, so if you have any liver health issues, discuss them with your doctor before starting this medicine.

Kidney

This medicine's elimination can be affected in patients with severe renal impairment. Therefore, if you have kidney health concerns, it's advisable to consult your doctor before taking Powercef S 375mg Injection 1.

Using Machines & Driving

No specific information suggests that Powercef S 375mg Injection 1 may affect your ability to drive or operate machinery. However, if you experience any side effects that could impair these abilities, refrain from such activities and consult your doctor.

Allergy

Powercef S 375mg Injection 1 is contraindicated in patients with known severe hypersensitivity to ceftriaxone, sulbactam or any other cephalosporin or penicillin antibiotic. If you're allergic to any of these, discuss it with your doctor before using this medicine.

Children

Powercef S 375mg Injection 1 can be given to children older than one month, but the dosage should be carefully given based on the child's body weight, which your child's doctor will decide. Consult your paediatrician before giving any medicine to your child.

Older Patients

Older patients should take Powercef S 375mg Injection 1 under medical supervision as they may be more susceptible to its side effects and might also have liver and kidney issues. Your doctor will guide you based on your health status.

Interactions of Powercef S 375mg Injection 1

Drug-Drug Interactions

Powercef S 375mg Injection 1 can interact with the following medicines:

Ringer's or Hartmann's solution: Powercef S 375mg Injection 1 should not be mixed with these calcium-containing IV solutions as it could lead to the formation of precipitates.
Oral anticoagulants like warfarin or heparin, when taken alongside Powercef S 375mg Injection 1, could increase the risk of bleeding due to enhanced anti-clotting effects.
Aminoglycosides: Antibiotics like gentamicin or neomycin should not be administered simultaneously with this medicine to avoid any physical incompatibility.
Uricosurics such as probenecid: can reduce the elimination of ceftriaxone from the body, leading to increased blood levels of this antibiotic.

Drug-Food Interactions

There are no specific known food interactions with Powercef S 375mg Injection 1.

Drug-Disease Interactions

Powercef S 375mg Injection 1 may interact with the following diseases:

Severe hypersensitivity: Patients allergic to ceftriaxone, sulbactam or any cephalosporin or penicillin antibiotic should avoid this medicine.
Gastrointestinal disease: Those with a history of gastrointestinal disease, particularly colitis, should use this injection cautiously as it could encourage the overgrowth of non-susceptible bacteria.
Renal impairment: Dosage adjustment may be needed for patients with severe kidney disease due to altered elimination and accumulation of the medicine.

Daily Dose

The recommended dose of Powercef S 375mg Injection 1 will be prescribed by your doctor, who will consider factors such as the severity of your condition and how you respond to the medicine.

Over Dose

Overdose of this injection is unlikely as a healthcare professional administers it. Symptoms of overdose include nausea, vomiting, or diarrhoea. It's important to inform your doctor if you experience these symptoms persistently. However, severe reactions due to overdose are unlikely.

Missed Dose

If you forget to take your scheduled dose of Powercef S 375mg Injection 1, consult your doctor for the next scheduled dose.

Store Powercef S 375mg Injection 1 in the refrigerator or at 2°C to 8°C. Do not freeze.
Keep this medicine out of sight and reach of children.
Always check the expiry date before administering.

Increase your water intake to help flush bacteria out of your system.
Quit smoking as it can worsen your condition and slow down recovery.

Fact Box

Drug Category	Cell Wall Synthesis Inhibitor, Beta-Lactamase Inhibitor
Therapeutic Category	Antibiotic
Available Dosage Types	Injection
Habit Forming	No
Ailment	Pneumonia, Urinary Tract Infection, Meningitis

What is Powercef S 375mg Injection 1 used for?

It's used to manage various bacterial infections, including respiratory, urinary, skin and soft tissue, and bone and joint infections.

How does Powercef S 375mg Injection 1 work?

It contains two active ingredients: ceftriaxone, which hampers bacterial cell wall synthesis leading to cell death, and sulbactam, which prevents antibiotic degradation by bacteria.

Can I take Powercef S 375mg Injection 1 if I'm allergic to penicillin?

No, it's not recommended, as you may have an allergic reaction. Please consult your doctor for alternatives.

What are the side effects of Powercef S 375mg Injection 1?

Side effects include diarrhoea, nausea, vomiting, skin rashes and pain at the injection site. If these persist or worsen, please consult your doctor immediately.

Can I use Powercef S 375mg Injection 1 during pregnancy or while breastfeeding?

It's best to consult your doctor before using this medicine during pregnancy or breastfeeding, as it may affect your baby.

What should I do if I overdose on Powercef S 375mg Injection 1?

Overdosing can lead to symptoms like nausea and vomiting. In such cases, seek immediate medical help.

How should I store Powercef S 375mg Injection 1?

The Powercef S 375mg Injection 1 should be stored in the refrigerator or at 2°C to 8°C. Do not freeze this injection.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Divya Chauhan

Medical Writer & Reviewer | 6 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

Bigshare Services Pvt. Ltd. 306, Right Wing, 3rd Floor Amrutha Ville, Opp.Yash Hyderabad - 500082 Telangana

Country of origin: INDIA

References

MedlinePlus. (2024). Ceftriaxone Injection. Retrieved from https://medlineplus.gov/druginfo/meds/a685032.html
U.S. National Library of Medicine. (2024). CEFTRIAXONE SODIUM- ceftriaxone sodium injection, powder, for solution. Retrieved from https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=942ea2a7-8a1b-405e-a802-2ff0debc388b&type=display
U.S. Food and Drug Administration. (2020). Ceftriaxone and Sulbactam for Injection. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/050608s047lbl.pdf
Ceftriaxone: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.-c). DrugBank. https://go.drugbank.com/drugs/DB01212
Sulbactam: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.-b). DrugBank. https://go.drugbank.com/drugs/DB09324

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