Pramirol 0.5 Tablet 10

Intas Pharmaceuticals Ltd

Strip of 10 Units

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Composition

Pramipexole (0.5 Mg)

Strength:

0.25 MG 0.5 MG 1 MG 1.5 MG 0.125 MG

Pramirol-0.5 Tablet is primarily used to manage Parkinson's disease, a condition marked by impaired movement. Belonging to a class of medicines known as dopamine agonists, it plays a key role in improving motor function and reducing symptoms.

In addition to managing Parkinson's disease, this medicine is also used in the management of restless legs syndrome (RLS), a neurological disorder that causes an uncontrollable urge to move the legs. It provides relief from the uncomfortable sensations associated with RLS, improving the patient's quality of life.

It's essential to take this medicine as directed by your doctor. Prior to starting this medicine, it's important to inform your doctor about any ongoing medications or pre-existing conditions. Remember to notify your doctor immediately if you experience any side effects. For best results, continue taking the medicine for the duration prescribed by your doctor.

Pramirol-0.5 Tablet is used for the following:

Management of Parkinson's disease symptoms: This includes tremors, stiffness, and slow movements.
Relief from Restless Legs Syndrome: This disorder causes an uncontrollable urge to move your legs, often accompanied by uncomfortable sensations.

Directions for Use of Pramirol 0.5 Tablet 10

Here are some simple steps to follow while taking Pramirol-0.5 Tablet:

Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet.
Stick to the recommended dose without exceeding it unless instructed by your doctor.
Do not stop taking this medicine without first consulting your doctor.

Pramirol-0.5 Tablet is taken orally.

Pramirol-0.5 Tablet may have the following common side effects:

Nausea
Dizziness
Drowsiness
Insomnia
Constipation
Headache

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolves on discontinuing the use of Pramirol-0.5 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Try taking Pramirol-0.5 Tablet with food to lessen this effect.
Dizziness: If you feel dizzy after taking this medicine, consider taking it at bedtime.

Pramirol-0.5 Tablet contains pramipexole (0.5 mg). The activity of pramipexole in the body can be described as follows:

Dopamine Receptor Activation: Pramipexole acts by stimulating dopamine receptors in the brain, particularly in the part known as the striatum that regulates movement. This stimulation helps improve motor function.
Symptom Reduction: By mimicking the action of dopamine, pramipexole reduces the motor deficits in Parkinson's disease caused by the loss of dopamine-producing neurons.
Relief in Restless Legs Syndrome: In cases of RLS, pramipexole's activation of dopamine receptors helps to reduce abnormal sensations in the legs, thereby providing relief from the main symptoms of this condition.

Pregnancy

Caution is advised while taking Pramirol-0.5 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

Pramirol-0.5 Tablet may inhibit lactation. If you are breastfeeding, you should discuss this with your doctor before starting the medicine.

Alcohol

Combining alcohol and Pramirol-0.5 Tablet can increase the risk of drowsiness and other side effects. It's best to avoid alcohol while taking this medicine.

Liver

Taking Pramirol-0.5 Tablet doesn't generally affect liver function, but if you have any liver health issues, it's wise to discuss them with your doctor before starting this medication.

Kidney

Since the dosage of Pramirol-0.5 Tablet needs to be adjusted in case of kidney impairment, it's advisable to consult your doctor if you have any kidney-related health problems before starting the medicine.

Using Machines & Driving

As Pramirol-0.5 Tablet can cause drowsiness and sudden sleep onset, it could impair your ability to drive or operate machinery. Be cautious and discuss this with your doctor.

Allergy

If you are allergic to pramipexole or any other ingredients present in Pramirol-0.5 Tablet, it's important not to take this medication without consulting your doctor first.

Children

Pramirol-0.5 Tablet is intended for adult use and is not recommended for use in children under 18 years of age. Always consult a doctor before giving any medicine to a child.

Older Patients

Older patients should take Pramirol-0.5 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Pramirol-0.5 Tablet interacts with the following medicines:

Central nervous system depressants: Pramipexole can enhance the sedative effects of other central nervous system depressants like benzodiazepines (such as diazepam and alprazolam) and opioids (like codeine and morphine).
Dopamine antagonists: Medications like neuroleptics (chlorpromazine, haloperidol) or metoclopramide can reduce the effectiveness of Pramirol-0.5 Tablet.
Medicines eliminated by renal tubular secretion: Medicines such as cimetidine, probenecid, or quinidine may interact with pramipexole as they share the same elimination pathway.

Drug-Food Interactions

There are no specific food interactions known with Pramirol-0.5 Tablet.

Drug-Disease Interactions

Pramirol-0.5 Tablet interacts with the following diseases:

Renal impairment: Dosage adjustment is necessary for patients with kidney disease as pramipexole is predominantly eliminated by the kidneys.
Psychotic disorders: Patients with a history of hallucinations or psychosis might experience worsening symptoms when taking Pramirol-0.5 Tablet.
Cardiovascular disease: Caution is recommended in patients with heart conditions due to the potential risk of orthostatic hypotension when taking this medication.

Daily Dose

The daily dose of Pramirol-0.5 Tablet should be taken as directed by your doctor. The dosage may differ based on the severity of your condition and how you respond to the medicine. Always stick to the prescribed dose and avoid changing it without consulting your doctor.

Over Dose

An overdose of Pramirol-0.5 Tablet can lead to symptoms like dizziness, nausea, or a headache. If you've accidentally taken more than the prescribed dose, don't panic but do let your doctor know about it.

Missed Dose

In case you forget to take Pramirol-0.5 Tablet at the scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never increase your dosage without consulting your doctor.

Store Pramirol-0.5 Tablet at room temperature.
Protect it from direct light, heat, and moisture.
Keep it out of reach of children.
Check the expiry date before use, and don't take it if expired.

If you have Parkinson's disease, regular physical activity can help manage motor symptoms. Gentle exercises like yoga or tai chi may be beneficial.
For those with restless legs syndrome, reducing caffeine intake can decrease symptoms, as it may interfere with sleep patterns. Always consult your doctor for personalised advice.

Fact Box

Drug Category	Dopamine Agonist
Therapeutic Category	Antiparkinsonian
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Parkinson's Disease, Restless Legs Syndrome

What is Pramirol-0.5 Tablet used for?

Pramirol-0.5 Tablet is primarily used to manage key motor symptoms in Parkinson's disease and restless legs syndrome, a neurological disorder.

How does Pramirol-0.5 Tablet work?

The active ingredient, pramipexole, stimulates dopamine receptors in the brain. This improves motor function and reduces symptoms in Parkinson's and restless legs syndrome.

Can Pramirol-0.5 Tablet be used for early stages of Parkinson's disease?

Yes, it can be used alone in the early stages of Parkinson's disease to manage motor symptoms such as tremors, stiffness, slow movement, and unsteadiness. Don’t take this medication directly without consulting your doctor.

How long does Pramirol-0.5 Tablet take to show effects for restless legs syndrome?

Symptom reduction is usually noticed within 1-2 weeks of starting the medicine at an appropriate dose, but the full effect may take 4-6 weeks.

Can I stop taking Pramirol-0.5 Tablet suddenly?

No, abruptly stopping pramipexole may cause withdrawal symptoms or a worsening of Parkinson's symptoms. Always consult your doctor before making any changes.

What should I do if I miss a dose of Pramirol-0.5 Tablet?

Take the missed dose as soon as you remember unless it's close to your next scheduled dose; in that case, skip the missed dose and continue with your regular schedule.

Can Pramirol-0.5 Tablet interact with other medicines?

Yes, it may interact with CNS depressants like benzodiazepines or opioids and medicines eliminated by renal tubular secretion like cimetidine or quinidine; always consult your doctor about potential interactions.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 9 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

References

Mirapex. (n.d.). Prescribing information for Mirapex tablets (pp. 3–5). https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020667s014s017s018lbl.pdf
Singh, R., & Parmar, M. (2023, April 17). Pramipexole. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK557539/
Pramipexole: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00413
Efficacy of pramipexole, a novel dopamine agonist, as monotherapy in mild to moderate Parkinson’s disease | Neurology. (n.d.). Neurology. https://www.neurology.org/doi/10.1212/WNL.49.3.724

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