Prograf 05 Mg Capsule 10

Prograf 0.5mg Capsule 10

Astellas Pharma Inc

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STRIP of 10 Units

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Composition

Tacrolimus (0.5 Mg)

Strength:

1 MG 0.5 MG

Prograf 0.5mg Capsule 10 is primarily used to prevent organ rejection in adults who have undergone liver, kidney, or heart transplants. This medication belongs to the class of immunosuppressants, which work by reducing the immune system's response to prevent it from attacking the transplanted organ.

In addition to its primary use, this medicine is often combined with other immunosuppressants to enhance its effectiveness, particularly during the critical initial phase after the transplant when the risk of rejection is high.

Before starting this medication, consult your doctor to determine the appropriate dosage and schedule. Ensure your doctor is aware of any pre-existing medical conditions or medications you are currently taking. If you notice any side effects, contact your doctor immediately. It is important to continue taking this medicine for the full duration prescribed by your doctor to achieve the best outcomes.

Prograf 0.5mg Capsule 10 is used for the following conditions:

Prevention of organ rejection after a liver transplant
Prevention of organ rejection following a kidney transplant
Managing the risk of organ rejection after a heart transplant

Directions for Use of Prograf 0.5mg Capsule 10

To ensure you are using Prograf 0.5mg Capsule 10 correctly, follow these steps:

Swallow the whole capsule with a glass of water.
Avoid chewing or breaking the capsule.
Always consult your doctor for specific advice on how to take this medicine.

Prograf 0.5mg Capsule 10 is taken orally.

Side Effects of Prograf 0.5mg Capsule 10

Prograf 0.5mg Capsule 10 may have the following common side effects:

Abnormal renal function: This refers to issues with your kidneys' ability to filter blood.
Hypertension: This means high blood pressure, which can lead to other health problems if not managed.
Diabetes mellitus: The medicine might increase your blood sugar levels, leading to diabetes.
Fever
Nausea
Headache
Hyperkalaemia: This is a condition where there is too much potassium in your blood.
Diarrhoea
Anaemia: This is a condition where you lack enough healthy red blood cells to carry oxygen to the tissues.
Leukopenia: This indicates a reduction in the number of white cells in your blood.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Fujigraf 0.5 Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Hypertension: Try taking this medicine at night if it causes high blood pressure during the day.
Diarrhoea: Consider taking Prograf 0.5mg Capsule 10 with food or milk to lessen this effect.

Prograf 0.5mg Capsule 10 contains tacrolimus (0.5 mg). Here is how it works:

Immune response suppression: Tacrolimus suppresses the immune response by inhibiting T-lymphocyte activation. T-lymphocytes are a type of white blood cell that play a key role in the immune system's reaction to foreign substances.
Calcineurin inhibition: Tacrolimus forms a complex with an intracellular protein called FKBP-12, and this complex inhibits an enzyme known as calcineurin phosphatase. This inhibition process suppresses the transcription of certain genes in T cells that are involved in triggering immune responses.

Pregnancy

Prograf 0.5mg Capsule 10 can potentially harm the foetus. It should be taken by pregnant women if the possible benefits outweigh the potential risks to the unborn baby. Consulting your doctor before taking this medicine is strongly advised.

Breastfeeding

As Prograf 0.5mg Capsule 10 is excreted in breast milk, breastfeeding should be avoided while taking this medication.

Alcohol

There's no specific information about the interaction of Prograf 0.5mg Capsule 10 with alcohol. It is a better to consult your doctor before consuming alcohol while taking this medicine.

Liver

If you have any liver conditions, be cautious when taking #sku_name#. Consult your doctor for advices tailored to your health status.

Kidney

Caution is advised when using this medicine if you have a history of kidney problems. Consult your doctor before starting this medicine.

Using Machines & Driving

This medicine may cause side effects like dizziness or blurred vision, which could affect your ability to drive or operate machinery. Avoid such activities until you know how this medicine affects you.

Allergy

Do not take Prograf 0.5mg Capsule 10 if you are allergic to tacrolimus or any other ingredients in the formulation.

Children

This medicine is not recommended for use in children, as its safety and efficacy have not been established for paediatric patients.

Older Patients

Elderly patients should take Prograf 0.5mg Capsule 10 under direct medical supervision, as they might be more susceptible to its side effects. If you are over 70 years of age, your doctor will guide you based on your overall health status.

Interactions of Prograf 0.5mg Capsule 10

Drug-Drug Interactions

Prograf 0.5mg Capsule 10 interacts with the following medicines:

Antifungal medications: Medicines such as clotrimazole, fluconazole, and itraconazole can increase the levels of tacrolimus in the body.
Calcium channel blockers: Medicines like diltiazem, verapamil, and nifedipine can also increase tacrolimus levels.
Macrolide antibiotics: Medications like erythromycin can raise tacrolimus levels.
Anti-tuberculosis medicine: Rifampin can significantly decrease tacrolimus concentrations.
Non-steroidal anti-inflammatory drugs (NSAIDs): These medicines may increase the nephrotoxic effect of tacrolimus.

Drug-Food Interactions

Prograf 0.5mg Capsule 10 interacts with grape fruit juice, which can significantly increase the concentration of tacrolimus in your body.

Drug-Disease Interactions

Prograf 0.5mg Capsule 10 interacts with the following diseases:

Hypersensitivity: If you have hypersensitivity to tacrolimus or any other ingredients in this medicine, such as polyoxyl 60 hydrogenated castor oil, you should avoid taking it.
Diabetes: Tacrolimus may cause new-onset diabetes after a transplant. Regular monitoring of blood glucose levels is required.
Renal Problems: Patients with renal issues should be cautious because tacrolimus can cause nephrotoxicity.

Daily Dose

The daily dose of Prograf 0.5mg Capsule 10 should be taken according to your doctor’s instructions. This dosage may vary based on the severity of your condition and your response to the medication.

Over Dose

In the event of an overdose of Fujigraf 0.5 Capsule, you may experience symptoms such as tremors, changes in kidney function, high blood pressure, and altered mental status.

Missed Dose

If you miss a dose of Fujigraf 0.5 Capsule, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed one and continue with your normal dose. Never adjust your dosage without consulting your doctor.

Store Prograf 0.5mg Capsule 10 at a temperature not exceeding 30°C.
Keep it safe from sunlight.
Keep out of reach of children.

Since Prograf 0.5mg Capsule 10 is used for organ transplant patients, maintaining a balanced diet is important. Include plenty of fresh fruits, vegetables, whole grains, and lean proteins in your diet to support your overall health and immune function.
Try to avoid grape fruit and grape fruit juice while taking this medication, as they can interfere with the way the medicine works. Check with your doctor for more specific advice about your diet.

Fact Box

Drug Category	Calcineurin Inhibitor
Therapeutic Category	Immunosuppressant
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Organ Rejection in Transplants

What is Prograf 0.5mg Capsule 10 used for?

Prograf 0.5mg Capsule 10 is used to prevent the body from rejecting a transplanted organ such as the liver, kidney, or heart in adult patients.

Can I take Prograf 0.5mg Capsule 10 with other medications?

Inform your doctor about all the medicines you are currently taking, as tacrolimus can interact with many medicines, potentially altering their effects.

How long do I need to take Prograf 0.5mg Capsule 10 after my transplant?

You will typically need to take immunosuppressants like Prograf 0.5mg Capsule 10 for life to prevent organ rejection. Don't stop taking it unless advised by your doctor.

What are the possible signs of organ rejection I should be aware of?

Look out for symptoms like fever, tenderness or pain over the transplanted organ, flu-like symptoms, changes in urine output or colour, yellowing of skin or eyes (jaundice), and unusual tiredness.

How often should I get my tacrolimus blood levels checked?

Initially, frequent blood checks will determine the right dose for you. Once stabilised, levels will be checked periodically, usually monthly or as directed by your doctor.

Can Prograf 0.5mg Capsule 10 harm an unborn baby if taken during pregnancy?

Yes, tacrolimus can harm an unborn baby. It is crucial to discuss this with your doctor if you are pregnant or planning to get pregnant while on this medication.

Can I breastfeed while taking Fujigraf 0.5 Capsule?

Tacrolimus is excreted in human milk; therefore, breastfeeding is not recommended while taking this medicine due to potential harm to the nursing infant.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Saniya K Mulla

Medical Writer & Reviewer | 5 years

MBBS

Check out Editorial Policy

Manufacturer details

Sangam Complex, Andheri - Kurla Rd, Dr. Charatsingh Colony, S B Singh Colony, J B Nagar, Andheri East, Mumbai, Maharashtra 400059

Country of origin: INDIA

References

U.S. Food and Drug Administration. (n.d.). Tacrolimus Capsules. FDA Draft Guidance. Retrieved on 1 April 2024 from https://www.accessdata.fda.gov/drugsatfda_docs/psg/Tacrolimus_caps_16729_RC12-12.pdf
Araya, A. A., & Tasnif, Y. (2023). Tacrolimus. Treasure Island (FL): StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK544318/
Tacrolimus: MedlinePlus drug information. (n.d.). MedlinePlus - Health Information from the National Library of Medicine. Retrieved from https://medlineplus.gov/druginfo/meds/a601117.html
Tacrolimus. (n.d.). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB00864
Tacrolimus Patient Information Leaflet: Non-Renal Transplant Indication (for renal patients only) Information about Tacrolimus, a drug used to suppress the immune system. (n.d.). NHS. https://www.uhsussex.nhs.uk/resources/tacrolimus-patient-information-leaflet-non-renal-transplant-indication-for-ward-patients-only/

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