Prograf 1mg Capsule 10

Astellas Pharma Inc

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STRIP of 10 Units

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Composition

Tacrolimus (1 Mg)

Strength:

1 MG 0.5 MG

Prograf 1 mg Capsule is primarily used to manage organ rejection in patients who have undergone liver, kidney, or heart transplants. It falls under the category of medicines known as immunosuppressants.

In addition to preventing organ rejection, this medicine also suppresses the immune system, making it less likely to attack and reject the transplanted organ.

It's crucial that you take this medicine as directed by your doctor. Before starting this medication, inform your doctor about any existing health conditions or ongoing medications. If you notice any side effects while taking this medicine, make sure you let your doctor know straight away. Continue taking Prograf 1 mg Capsule for the entire duration recommended by your doctor for optimal results.

Prograf 1 mg Capsule is used for the following:

Prevention of organ rejection after liver transplantation
Keeping organs safe from immune system attacks following kidney transplantation
Protection against organ rejection post-heart transplant

Directions for Use of Prograf 1mg Capsule 10

Swallow the capsule whole with a glass of water.
Do not chew, crush or open the capsule.
Consistently take the capsule with or without food to maintain stable absorption.
Always consult your doctor for specific advice regarding dosage and administration.

Prograf 1 mg Capsule is taken orally.

Prograf 1 mg Capsule can have the following side effects:

Tremor: This could mean uncontrollable shaking in a part of your body.
Headache
Hypertension: This is when your blood pressure becomes too high.
Gastrointestinal disturbances: These could include diarrhoea, nausea, or vomiting.
Hyperglycaemia: This condition involves high blood sugar levels.
Hypomagnesaemia: This means you have lower than normal magnesium levels in your blood.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Prograf 1 mg Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines to manage common side effects:

Gastrointestinal disturbances: Try taking Prograf 1 mg Capsule with food to lessen this effect.
Hyperglycaemia: Consider adjusting your meal times when taking this medicine to help manage your blood sugar levels.

Prograf 1 mg Capsule contains tacrolimus (1 mg). Here's how it works on your body:

Calcineurin Inhibition: Tacrolimus inhibits calcineurin, an enzyme that plays a crucial role in activating T-cells, which are a type of immune cell.
Immune System Suppression: By blocking the activity of calcineurin, tacrolimus effectively suppresses T-cell activity. This reduces your immune system's ability to attack and reject the transplanted organ.

Pregnancy

Caution is advised while taking Prograf 1 mg Capsule if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, it's advisable to discuss with your doctor before starting Prograf 1 mg Capsule.

Alcohol

While on Prograf 1 mg Capsule, avoid consuming alcohol as it might affect the efficacy of the medicine.

Liver

Care should be taken when using Prograf 1 mg Capsule if you have mild to moderate liver issues. This medicine may affect liver function, so consult your doctor before use.

Kidney

If you have any kidney health concerns, take caution before using Prograf 1 mg Capsule. Discuss these concerns with your doctor before starting this medication.

Using Machines & Driving

As Prograf 1 mg Capsule can potentially cause side effects like tremors and headaches, caution is advised while driving or operating heavy machinery.

Allergy

Prograf 1 mg Capsule should not be taken if you have an allergy to tacrolimus or any of the other ingredients in the capsule.

Children

Prograf 1 mg Capsule is meant for adult use. It's not recommended for children under 18 years of age without medical advice.

Older Patients

Older patients should take Prograf 1 mg Capsule under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Prograf 1 mg Capsule interacts with the following medicines:

Antifungals: Medicines such as ketoconazole may increase the level of tacrolimus in your blood.
Antibiotics: Medicines like rifampin may decrease the level of tacrolimus in your blood.
Other immunosuppressants: Tacrolimus can interact with medicines like cyclosporine, which could further increase its levels.

Drug-Food Interactions

This medication interacts with certain foods. Specifically:

Grapefruit and Grapefruit Juice: These can raise the levels of tacrolimus in your body, increasing the chance of side effects.

Drug-Disease Interactions

Prograf 1 mg Capsule interacts with the following diseases:

Kidney Disease: As tacrolimus can potentially worsen kidney function, caution is necessary for individuals with pre-existing kidney disease.
Hypersensitivity: The medication is contraindicated in people allergic to tacrolimus or any component of the capsule.

Daily Dose

Your doctor will prescribe the daily dose of Prograf 1 mg Capsule based on factors like your health condition and how your body responds to the medicine. Always stick to the prescribed dosage and don't change it without consulting your doctor. For further details, you can refer to the package insert.

Over Dose

If you accidentally take more Prograf 1 mg Capsule than prescribed, you might experience common side effects like headaches or stomach upsets. If these symptoms persist or get worse, inform your doctor without delay.

Missed Dose

If you've missed a dose of Prograf 1 mg Capsule, take it as soon as you remember. But if it's nearly time for your next dose, ignore the missed one and continue with your regular schedule. Never alter your dosage without consulting your doctor.

Keep the Prograf 1 mg Capsule in its original container until use.
Store it at room temperature, ideally between 15-30°C.
Make sure the location is free from excessive light and moisture.
Always keep this medicine out of the reach of children.
Ensure you use the product before its expiry date.

Avoid grapefruit and grapefruit juice while taking Prograf 1 mg Capsule; these can increase the amount of tacrolimus in your blood.
Given that tacrolimus could potentially raise your blood sugar levels, maintain a diet low in sugar to manage this risk effectively.

Fact Box

Drug Category	Calcineurin Inhibitor
Therapeutic Category	Immunosuppressant
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Organ Rejection Prevention (Liver, Kidney, Heart Transplants)

What is Prograf 1 mg Capsule and what is it used for?

Prograf 1 mg Capsule is an immunosuppressant medicine containing tacrolimus. It's used to prevent organ rejection after liver, kidney, or heart transplants.

How does Prograf 1 mg Capsule work?

Prograf 1 mg Capsule contains tacrolimus which inhibits an enzyme called calcineurin, thereby reducing the immune system's ability to reject a transplanted organ.

Can I take Prograf 1 mg Capsule with food?

Yes, you can take Prograf 1 mg Capsule with or without food. But ensure consistency for better absorption of the medicine.

What are some common side effects of Prograf 1 mg Capsule?

Common side effects include tremors, headache, high blood pressure, stomach disturbances like diarrhoea and nausea, and high blood sugar levels.

Are there any precautions I should take when using Prograf 1 mg Capsule?

Avoid grapefruit and grapefruit juice as they can alter tacrolimus levels in your blood. Also, avoid live vaccines due to the medicine's immunosuppressive effects.

Can other medicines affect how Prograf 1 mg Capsule works?

Yes, antifungals and antibiotic medicines can alter the effectiveness of Prograf 1 mg Capsule. Always consult your doctor before taking any new medicine.

How should I store Prograf 1 mg Capsule?

Store Prograf 1 mg Capsule at room temperature (between 15-30°C), away from moisture and light. Keep the capsules in their original container until use.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Sangam Complex, Andheri - Kurla Rd, Dr. Charatsingh Colony, S B Singh Colony, J B Nagar, Andheri East, Mumbai, Maharashtra 400059

Country of origin: INDIA

References

Tacrolimus: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00864
Astellas Pharma US, Inc. (1994). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
HIGHLIGHTS OF PRESCRIBING INFORMATION. (2022). [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/050708s054,050709s047,204096s010lbl.pdf
Veloxis Pharmaceuticals, Inc. (1994). ENVARSUS XR. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/206406s010lbl.pdf
HIGHLIGHTS OF PRESCRIBING INFORMATION. (1994). [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/050708s052,050709s044,210115s004lbl.pdf

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