Prucolpride 2 Tablet 10

Steris Healthcare

Strip of 10 Units

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MRP ~~₹263~~

₹215.66

₹26.30/Units

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Composition

Prucalopride (2 Mg)

Strength:

2 MG 1 MG

Prucolpride 2 Tablet 10 is mainly used to manage chronic constipation. This medicine is a part of a group known as selective serotonin-4 (5-HT4) receptor agonists.

While its primary use is for managing chronic idiopathic constipation in adults, it's also suitable when other laxatives have not provided adequate relief. The medicine helps stimulate gut movement and facilitates bowel movements, providing relief from constipation symptoms and improving quality of life.

Before you begin taking this medicine, it's crucial to inform your doctor about any pre-existing conditions or any ongoing medications. Any side effects noticed while on this medicine should be reported to your doctor immediately. It's essential to continue taking the medicine for the duration prescribed by your doctor for optimal results.

Prucolpride 2 Tablet 10 is used for the following:

Management of chronic idiopathic constipation in adults: This is a condition where bowel movements are infrequent, hard, or incomplete without any identifiable cause.
Improvement of gut motility: It helps in maintaining regular and easy bowel movements.
Relief for patients who have not found adequate relief from other laxatives: If other types of laxatives are ineffective, this medicine can be used to manage constipation.
Enhancement of quality of life: By managing chronic constipation effectively, it aids in improving the quality of life.

Directions for Use of Prucolpride 2 Tablet 10

Follow these instructions while taking Prucolpride 2 Tablet 10:

Swallow the tablet whole with a glass of water.
Do not chew or crush the tablet.
Take the medicine according to your doctor's instructions.
Do not stop taking this medicine without consulting your doctor first.
Inform your doctor about all other medicines you are currently taking.

Prucolpride 2 Tablet 10 is taken orally.

The use of Prucolpride 2 Tablet 10 may lead to some common side effects, which include:

Headache
Nausea
Abdominal pain
Appetite reduction: You might experience a decrease in your appetite.
Dizziness
Dyspepsia: This means you could have indigestion or discomfort in your stomach.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Prucolpride 2 Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips for managing two common side effects:

Nausea: Try taking Prucolpride 2 Tablet 10 after having a light meal to reduce this effect.
Dyspepsia: If you are experiencing indigestion, consider taking this medicine with meals to lessen the discomfort.

Prucolpride 2 Tablet 10 contains prucalopride (2 mg), which works on the body as follows:

Selective 5-HT4 receptor agonist: Prucalopride stimulates the 5-HT4 receptors in the gastrointestinal tract. These receptors play a significant role in controlling gut movement.
Enhances acetylcholine release: By stimulating these receptors, prucalopride indirectly enhances the release of acetylcholine, a neurotransmitter that regulates gut motility.
Promotes peristalsis: The increased release of acetylcholine promotes peristalsis, which involves the contraction and relaxation of intestinal muscles, propelling the contents of the gut forward. This action accelerates gastrointestinal transit and facilitates bowel movements.

Pregnancy

Caution is advised while taking Prucolpride 2 Tablet 10 if you are pregnant. It's best to consult your doctor before taking this medicine.

Breastfeeding

Prucolpride 2 Tablet 10 should be used with caution if you are breastfeeding. Discuss with your doctor to understand potential risks and benefits.

Alcohol

It is advisable to avoid alcohol consumption during the course of this medicine.

Liver

If you have liver health issues, it's crucial to discuss them with your doctor before starting Prucolpride 2 Tablet 10. This medicine may impact liver function.

Kidney

Caution is advised before taking Prucolpride 2 Tablet 10 if you have a history of kidney problems. Consult your doctor prior to using this medicine.

Using Machines & Driving

Prucolpride 2 Tablet 10 may cause dizziness. Be cautious while driving or operating machinery until you know how this medicine affects you.

Allergy

Avoid Prucolpride 2 Tablet 10 if you're allergic to prucalopride or any other ingredients of the tablet. It's important to discuss any known allergies with your doctor before starting this medication.

Children

Prucolpride 2 Tablet 10 isn't recommended for use in children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Prucolpride 2 Tablet 10 under medical supervision, as they might be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Prucolpride 2 Tablet 10 interacts with the following medicines:

Anticholinergic medications: Medicines like atropine and ipratropium may counteract the effects of Prucolpride 2 Tablet 10 on gut motility.
Antifungals: Medicines, such as ketoconazole and itraconazole, can increase the plasma concentration of prucalopride, potentially enhancing side effects.
Serotonergic medications: Combining Prucolpride 2 Tablet 10 with serotonergic medicines like selective serotonin reuptake inhibitors (SSRIs), for example, fluoxetine and sertraline, may increase the risk of serotonin syndrome, a potentially life-threatening condition.

Drug-Food Interactions

There are no specific food interactions known for Prucolpride 2 Tablet 10.

Drug-Disease Interactions

Prucolpride 2 Tablet 10 interacts with the following diseases:

Kidney or liver disease: Patients with these conditions may need to use Prucolpride 2 Tablet 10 with caution as it could affect their condition.
Inflammatory bowel disorders: Conditions like Crohn's disease and ulcerative colitis may worsen when using this medication.
Gastrointestinal perforation or obstruction: Intestinal blockages could be aggravated by using Prucolpride 2 Tablet 10.

Daily Dose

Your daily dose of Prucolpride 2 Tablet 10 should be as recommended by your doctor. This dosage depends on individual factors such as the severity of your condition and how well you respond to the medicine. Remember, it's important to stick to the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If by chance you take more than the prescribed dose of Prucolpride 2 Tablet 10, you may experience increased side effects like headaches or nausea. If you feel unwell or if these symptoms persist, inform your doctor.

Missed Dose

In case you miss a dose of Prucolpride 2 Tablet 10, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and go back to your regular schedule. Don't increase your dosage without speaking to your doctor.

Keep Prucolpride 2 Tablet 10 at room temperature, ideally below 30°C.
Safeguard the medicine from exposure to direct sunlight, heat, and moisture.
Always store this medicine out of reach of children.
Ensure you use the product before its expiry date.

Increasing your fibre intake can help manage chronic constipation. Include more whole grains, fruits, and vegetables in your diet.
Regular physical activity can improve your bowel movements. Try including a brisk walk or light exercise in your daily routine.

Fact Box

Drug Category	5-HT4 Receptor Agonist
Therapeutic Category	Gastrointestinal Agent
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Idiopathic Constipation

What is Prucolpride 2 Tablet 10 used for?

Prucolpride 2 Tablet 10 is primarily used to manage chronic constipation in adults when other laxatives have not provided adequate relief.

How does Prucolpride 2 Tablet 10 work?

Prucolpride 2 Tablet 10 contains prucalopride which stimulates gut movement, making bowel movements easier and reducing symptoms of chronic constipation.

Is it safe to use Prucolpride 2 Tablet 10 during pregnancy?

It's crucial to consult your doctor if you're pregnant before consuming this medicine.

Can I take Prucolpride 2 Tablet 10 with other medications?

Yes, but it's essential to inform your doctor about all the medicines you're currently taking as some may interact with Prucolpride 2 Tablet 10.

Are there any side effects of taking Prucolpride 2 Tablet 10?

Possible side effects include headache, nausea, abdominal pain, decreased appetite, dizziness and dyspepsia. If these persist or worsen, consult your doctor.

Can I stop taking Prucolpride 2 Tablet 10 once my symptoms improve?

No, it's important to complete the course recommended by your doctor. Stopping prematurely can lead to a recurrence of symptoms.

How should I store Prucolpride 2 Tablet 10?

Prucolpride 2 Tablet 10 should be stored at room temperature, away from direct sunlight, heat, and moisture. Keep out of reach of children and pets.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Tanaji Chowk, Ambedkar Nagar, Kurla West, Kurla, Mumbai, Maharashtra 400070

Country of origin: INDIA

References

Shire. (2018). Highlights of prescribing information for motegrity [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210166s000lbl.pdf
Prucalopride: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a619011.html
DailyMed - MOTEGRITY- prucalopride tablet, film coated. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bca1e4c6-4b2b-4876-8ab3-654629c4ff1b
Prucalopride: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06480

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