Ranozex 500 Mg Tablet Er 10

Ranozex Tablet 10

Sun Pharma Laboratories Ltd.

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Composition

Ranolazine (500 Mg)

Strength:

500 MG 1000 MG

Ranozex 500 mg tablet is a prescription medication for adults with chronic angina. Chronic angina is when the heart doesn't receive enough oxygen in the myocardial portion due to an improper supply of blood, causing chest pain and discomfort. Ranozex 500 mg tablet works by improving blood flow to the heart and reducing the heart's workload, thereby relieving the symptoms of chronic angina.

Ranozex 500 mg tablet belongs to a class of medications known as antianginal. Numerous clinical trials have evaluated the efficacy and safety of the Ranozex 500 mg tablet. Ranozex 500 mg tablet significantly improved exercise tolerance and reduced the frequency of angina attacks in patients with chronic angina. In addition to its antianginal effects, Ranozex 500 mg tablet has been shown to benefit cardiac function.

Ranozex 500 mg tablet has demonstrated improved left ventricular diastolic function in patients with coronary artery disease. However, it may interact with certain medications and should be used carefully in patients with certain medical conditions, such as a liver problem or kidney disease.

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Angina Pectoris: Angina pectoris is a condition in which chest pain or discomfort like squeezing, pressure, heaviness or tightness occurs when the heart does not receive enough oxygen-rich blood. Ranozex 500 mg tablet is a prescription for treating adults' chronic angina pectoris.

Ranozex 500 mg tablet is a prescription medication. You should take medicine exactly as your healthcare provider directed.
The recommended dose of Ranozex 500 mg tablet is typically taken with food.
The tablet should be swallowed whole with water and not crushed, chewed, or broken.
Do not stop taking the medication without consulting your healthcare provider. Stopping the medication suddenly may cause your angina symptoms to worsen.

Ranozex 500 mg tablet is a prescription medication typically administered orally as tablets.

The most common side effects of Ranozex 500 mg tablet include

Nausea and Vomiting: Nausea and vomiting are side effects of Ranozex 500 mg tablet. Nausea may be accompanied by stomach discomfort or pain. These side effects are generally mild to moderate in severity and usually resolve independently without needing medical attention.
Constipation: Constipation is another common side effect of the Ranozex 500 mg tablet. You may experience difficulty passing stools or infrequent bowel movements.
Dizziness: You may experience dizziness when using Ranozex 500 mg tablet. Dizziness may be accompanied by lightheadedness or a sensation of spinning.
Headache: Headache is a common side effect of the Ranozex 500 mg tablet. Headaches may be mild to moderate in severity and may be accompanied by neck or shoulder pain.
Weakness: You may experience fatigue, malaise, or general weakness while using Ranozex 500 mg tablet. If weakness persists or becomes severe, patients should contact their healthcare provider.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing Ranozex 500 mg tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Ranozex 500 mg tablet is used for chronic angina in adults. It works by blocking the late sodium current in the heart, which reduces the amount of calcium overload in the myocardial part of the heart from the sodium/calcium exchanger. This improves mitochondrial function and oxygen-rich blood flow, reducing angina symptoms.
Ranozex 500 mg tablet also has other effects that may help with angina and heart rhythm problems. For example, it can slightly prolong the QT interval (QT interval is a measure of the time between the start of the heart's electrical activity and the end of its electrical recovery, which, if prolonged, can cause a heart rhythm problem). Ranozex 500 mg tablet also changes how the heart uses energy, which can help reduce oxygen demand and improve heart function.

Pregnancy

Ranozex 500 mg tablet is not advised for use in pregnancy unless absolutely required. If you are pregnant, your doctor will evaluate the benefits and potential risks before prescribing this medicine.

Breastfeeding

Ranozex 500 Mg Tablet should not be used when breastfeeding due to the lack of safety data.

Alcohol

Consuming alcohol while taking Ranozex 500 mg tablet may increase the risk of side effects such as dizziness, drowsiness, and lightheadedness. It is advised to avoid alcohol consumption while taking this medication.

Liver

Ranozex 500 mg tablet may cause liver damage in some patients, particularly those with existing liver problems. Before starting this medication, you must inform your healthcare provider if you have any liver problems.

Kidney

Patients with kidney problems may require dosage adjustments or should be monitored by a doctor while taking Ranozex 500 mg tablet. Consult your doctor if you have any kidney problems before starting this medication.

Using Machines & Driving

Ranozex 500 mg tablet may cause dizziness and lightheadedness, impairing your ability to operate machinery or drive. It is essential to avoid driving or operating machinery until you know how Ranozex 500 mg tablet affects you.

Allergy

Patients allergic to Ranozex 500 mg tablet or its components should not use this medication. You must inform your healthcare provider of known allergies before starting the Ranozex 500 mg tablet.

Children

The safety and effectiveness of the Ranozex 500 mg tablet have not been established in children under 18. This medication should only be used in children under the direction of a healthcare provider.

Older Patients

Older patients over 65 may be more susceptible to specific side effects of Ranozex 500 mg tablet, such as dizziness and lightheadedness. Monitoring these patients closely and adjusting the dosage as necessary is crucial.

Drug-Drug Interactions

Ranozex 500 mg tablet can interact with medications including

Antibiotics such as clarithromycin and telithromycin are used to treat bacterial infections. These medications may increase the blood levels of Ranozex 500 mg tablet, increasing the risk of side effects. The dose of Ranozex 500 mg tablet may need to be adjusted if taken with these medications.
Lipid-lowering drugs like simvastatin and atorvastatin may increase the blood levels of Ranozex 500 mg tablet, raising the likelihood of side effects.
Antifungal medications such as itraconazole, ketoconazole, voriconazole, and posaconazole used to treat various fungal infections.
HIV medications like protease inhibitors may increase the possibility of undesirable effects.
Antidepressants such as nefazodone manage depression and may interact with Ranozex 500 mg tablet by increasing the possibility of undesirable effects.
Antipsychotic medications such as haloperidol may increase the risk of abnormal heart rhythms when taken with Ranozex 500 mg tablet.
Medications that affect the heart rhythm, such as quinidine, dofetilide, or sotalol, may increase the risk of abnormal heart rhythms when taken with Ranozex 500 mg tablet. Your healthcare provider may need to monitor your heart rhythm if you take these medications together.

Drug-Food Interactions

Ranozex 500 mg tablet can interact with foods including

Grapefruit and grapefruit juice: Grapefruit and grapefruit juice can increase the amount of Ranozex 500 mg tablet in your bloodstream, increasing the risk of side effects. Avoiding grapefruit and grapefruit juice while taking Ranozex 500 mg tablet is recommended.
Alcohol: Drinking alcohol while taking Ranozex 500 mg tablet can increase the risk of dizziness and lightheadedness. It is recommended to avoid alcohol while taking this medication.
Caffeine: Caffeine can also increase the risk of dizziness and lightheadedness when taken with Ranozex 500 mg tablet. Limiting or avoiding caffeine-containing foods and drinks, such as coffee, tea, and chocolate, is recommended.
High-fat meals: High-fat meals can slow the absorption of Ranozex 500 mg tablet, affecting how well the medication works. Taking Ranozex 500 mg tablet with a low-fat meal or on an empty stomach is recommended for the best absorption.
Calcium-rich foods: Calcium-rich foods, such as dairy products, can decrease the absorption of the Ranozex 500 mg tablet. Taking Ranozex 500 mg tablet at least 2 hours before or after consuming calcium-rich foods is recommended.

Drug-Disease Interactions

Ranozex 500 mg tablet can interact with Diseases, including

Liver disease: Ranozex 500 mg tablet is metabolised in the liver and should be used cautiously in patients with liver disease.
Kidney disease: Ranozex 500 mg tablet is excreted by the kidneys and should be used carefully in patients with kidney disease. A dose adjustment may be necessary for patients with moderate to severe kidney disease.
Disease related to heart rhythm: Ranozex 500 mg tablet may prolong the QT interval of the heart's electrical cycle. Therefore, it should be used in patients with a history of QT prolongation or other heart rhythm disorders.

Daily Dose

The recommended daily dose of Ranozex 500 mg tablet is once daily, with food, as directed by your doctor. The dosage may change based on individual factors such as the severity of the condition and response to treatment. It is essential to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you or someone else takes an excessive amount of Ranozex 500 mg tablet by accident, it is essential to take immediate medical attention from your doctor or nearby hospital. Symptoms of an overdose include nausea or vomiting, stomach pain, mild dizziness (vertigo), and constipation.

Missed Dose

If you forgot to take a Ranozex 500 mg tablet, take it as soon as you remember or as instructed by your healthcare provider. If the time for the next dosage is close, it is recommended to skip the missed one and resume your regular dosage pattern. Never increase your dosage without consulting your doctor.

Store Ranozex 500 mg tablet at room temperature (15-25ºC).
Please protect it from light and moisture.
Keep Ranozex 500 mg tablet away from children.
Do not use Ranozex 500 mg tablet after the expiry date has passed.

Maintain a healthy diet: A healthy diet can help enhance heart health and reduce the risk of angina. A heart-healthy diet includes fruits, vegetables, whole grains, lean protein, and healthy fats and does not use high-fat-containing food.
Limit alcohol consumption: Alcohol can interact with Ranozex 500 mg tablet and increase the risk of side effects such as dizziness and lightheadedness. It is advised to limit alcohol consumption or avoid it altogether while taking Ranozex 500 mg tablet.
Quit smoking: Smoking can worsen angina symptoms and increase the risk of heart disease. Quitting smoking can boost overall heart health and increase the effectiveness of the Ranozex 500 mg tablet.
Exercise regularly: Regular exercise can help improve heart health and reduce the risk of angina. Talking to your healthcare provider before starting a new exercise routine is essential.
Manage stress: Stress can trigger angina symptoms and worsen heart health. Practicing stress-management techniques such as meditation, deep breathing, and yoga can help reduce stress and improve heart health.

Ranozex 500 mg tablet should be taken with food to avoid stomach discomfort.
In diabetes patients, Ranozex 500 mg tablet lowers HbA1c and blood sugar levels. It is advised to monitor sugar levels regularly.
Do not exceed the recommended dosage of Ranozex 500 Mg Tablet.
Take this medication for the appropriate amount of time.
If you stop taking this drug suddenly without consulting your doctor, your condition may worsen.
Ranozex 500 mg tablet may cause ECG abnormalities (QTc interval prolongation). It is suggested that an ECG be performed within 1 to 2 weeks of beginning the medication.

Fact Box

Drug Category	Piperazine derivative
Therapeutic Category	Antianginal
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Angina

Can Ranozex 500 mg tablet damage kidneys?

While taking Ranozex 500 mg tablet, patients with kidney disease or those at risk for kidney disease should be under close observation. Ranozex 500 mg tablet is advised against being used in individuals with significant renal impairment. Consult your healthcare professional if you're worried about how it might affect your kidneys to determine the best treatment course.

Is Ranozex 500 mg tablet good for the heart?

Yes, Ranozex 500 mg tablet is a medication primarily used to treat chronic angina by improving blood flow to the heart muscles and reducing the heart's workload. It is considered safe and effective when used as directed.

What class of drug is Ranozex 500 mg tablet?

Ranozex 500 mg tablet consists of Ranolazine, a member of the Anti-anginals class of medications. It is used to treat chronic angina pectoris.

Can I take Ranozex 500 mg tablet at night?

Your healthcare provider will determine the timing of when to take the Ranozex 500 mg tablet, which will be based on your medical condition and needs.

When is the best time to take Ranozex 500 mg tablet?

Ranozex 500 mg tablet should be taken as directed by your healthcare professional, usually once daily at the same times each day, with meals. It is critical to follow your healthcare provider's instructions to ensure maximum benefit and to reduce the chance of side effects.

Does Ranozex 500 mg tablet raise blood pressure?

No, Ranozex 500 mg tablet is not known to raise blood pressure. It is used to treat angina, a condition with decreased blood flow to the heart, resulting in discomfort or chest pain.

Does Ranozex 500 mg tablet prevent heart attacks?

No, Ranozex 500 mg tablet does not prevent heart attack. Ranozex 500 mg tablet treats angina (heart-related chest pain) and helps prevent fresh angina episodes. Once an acute attack has begun, Ranozex 500 mg tablets cannot stop it. Ranozex 500 mg Tablets lower the heart's oxygen requirement and relax the cardiac muscles.

Does Ranozex 500 mg tablet increase creatinine?

Some people who use Ranozex 500 mg tablet may see increased serum creatinine levels. However, this effect is often modest and temporary and has no undesirable effects. Patients on Ranozex 500 mg tablet, especially those with pre-existing kidney issues or who are at risk for kidney disease, should have their creatinine levels checked regularly.

Does Ranozex 500 mg tablet make you sleepy?

Yes, Ranozex 500 mg tablet can make you sleepy. However, discussing this with your healthcare provider is recommended if you experience excessive sleepiness while taking Ranozex 500 mg tablet.

Who should not take Ranozex 500 mg tablet?

Ranozex 500 mg tablet should not be taken by individuals who are allergic to the medication or any of its components, have severe liver disease, are taking certain medications that may interact with Ranozex, have certain heart conditions, or are pregnant or breastfeeding.

Last Updated On 15 Feb. 2024 | 4:55AM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

References

KD. Tripathi. Cardiovascular drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page -554.
Gilead Sciences, Inc. U.S. Food & Drug Administration. [Revised on January 2016] [Accessed on 4th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021526s029lbl.pdf
Gilead Sciences, Inc. Ranolazine. [Revised on April 2010] [Accessed on 4th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d442b8c-97a8-40a9-8603-f9cd0542cedc
Ranolazine. Torrent Pharmaceuticals ltd. [Revised on July 2019] [Accessed on 4th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1344.pdf
Ranolazine - StatPearls - NCBI Bookshelf (nih.gov):https://www.ncbi.nlm.nih.gov/books/NBK507828/

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