Rapacan 1 Tablet 10

Biocon Ltd

Strip of 10 Units

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MRP ~~₹2524~~

₹2019.2

₹252.4/Units

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Composition

Sirolimus (1 Mg)

Rapacan 1 Tablet is primarily used to prevent organ rejection in patients who have undergone kidney transplantation. This medicine is part of a group known as immunosuppressants.

This medicine is also used for managing a rare lung disorder called lymphangioleiomyomatosis (LAM). LAM is characterised by abnormal growth of smooth muscle cells in the lungs that can lead to progressive respiratory failure in women of childbearing age.

It's important to take this medicine as directed by your doctor. You should inform your doctor about any pre-existing conditions or ongoing medications before starting this medication. If you notice any side effects while on it, notify your doctor immediately. It's crucial to continue taking the medicine for the duration prescribed by your doctor to get the best results.

Rapacan 1 Tablet serves the following purposes:

Preventing organ rejection in kidney transplant patients
Regulating immune response post kidney transplantation
Helping manage lymphangioleiomyomatosis (LAM), a rare lung disorder

Directions for Use of Rapacan 1 Tablet 10

Before you take Rapacan 1 Tablet, keep these instructions in mind:

Always swallow the tablet whole with a glass of water.
Avoid crushing, chewing, or splitting the tablet.
Do not exceed the recommended dosage without consulting your doctor.
Remember, it's crucial not to stop taking this medicine without speaking to your doctor first.

Rapacan 1 Tablet is taken orally.

Rapacan 1 Tablet may cause the following common side effects:

Infections: You might be more prone to infections while on this medication.
Hyperlipidemia: This refers to an increase in fats (lipids) in your blood.
Hypertriglyceridemia: Too much of a type of fat (triglycerides) in your blood.
Anaemia: This could lead to feeling tired and having a lack of energy.
Thrombocytopenia: A decrease in blood platelets, which can lead to easy bruising and excessive bleeding.
Leukopenia: A decrease in white blood cells that help the body fight off infections.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Rapacan 1 Tablet. However, if you experience any serious side effects or worsening of any symptoms, please consult your doctor. Here are some general guidelines for managing common side effects:

Infections: Ensure you maintain good personal hygiene and avoid people with contagious diseases.
Anaemia: Try taking Rapacan 1 Tablet with food rich in iron like spinach or red meat.

Rapacan 1 Tablet contains sirolimus (1mg) and works as follows:

Immune Response Inhibition: Sirolimus inhibits the activation and multiplication of T-lymphocytes. These are key parts of the immune system that could cause organ rejection.
mTOR Inhibition: By binding to the protein FKBP-12, sirolimus forms a complex that inhibits the activity of another protein known as mTOR. mTOR is involved in cell growth and survival. By inhibiting mTOR, sirolimus helps in suppressing the immune response, thus reducing the risk of organ rejection.

Pregnancy

If you are pregnant or planning to conceive, caution is advised when taking Rapacan 1 Tablet. Always discuss this with your doctor beforehand.

Breastfeeding

Rapacan 1 Tablet is not recommended for breastfeeding women. It's crucial to consult your doctor about the potential risks and benefits.

Alcohol

There's no known interaction between alcohol and Rapacan 1 Tablet, but it's always wise to limit alcohol consumption while on medication.

Liver

Caution is recommended for those with liver issues while taking Rapacan 1 Tablet. This medication could affect liver function, so discussing any liver-related concerns with your doctor is advisable.

Kidney

If you have a history of kidney problems, be cautious before taking Rapacan 1 Tablet. Always consult your doctor first.

Using Machines & Driving

Rapacan 1 Tablet may not directly affect your ability to drive or operate machinery. However, if you feel unwell or have any symptoms that might affect your concentration, avoid these activities until you consult your doctor.

Allergy

Rapacan 1 Tablet is contraindicated if you have hypersensitivity to sirolimus or any other ingredients in the formulation. Always tell your doctor about any allergies before taking this medicine.

Children

Rapacan 1 Tablet is not typically prescribed for children under 18 years of age. This medication should be prescribed only under the strict supervision of a doctor.

Older Patients

Older patients should use Rapacan 1 Tablet under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Rapacan 1 Tablet interacts with the following medicines:

Immunosuppressants: Rapacan 1 Tablet might interact with other immunosuppressants like cyclosporine and tacrolimus, affecting their levels in the body.
Antifungals: Medicines like ketoconazole, itraconazole, and voriconazole can increase the levels of sirolimus in the blood, leading to more side effects.
Lipid-lowering agents: These medications may interact with Rapacan 1 Tablet, potentially increasing the risk of high lipid levels in your blood (hyperlipidaemia).
Calcium channel blockers: Concomitant use of medicines like nifedipine or amlodipine with Rapacan 1 Tablet may alter sirolimus levels in the body.

Drug-Food Interactions

Certain foods can interact with Rapacan 1 Tablet:

Grapefruit Juice: Grapefruit juice should be avoided while taking this medicine as it can increase sirolimus levels in the blood, potentially leading to increased side effects.

Drug-Disease Interactions

Rapacan 1 Tablet interacts with the following diseases:

Hyperlipidaemia: Patients with pre-existing high lipid levels in the blood should be cautious as sirolimus can exacerbate this condition.
Skin Cancer: Patients with a history of skin cancer or significant sun exposure should be monitored closely, as sirolimus may increase the risk of skin malignancies.

Daily Dose

The daily dose of Rapacan 1 Tablet will be determined by your doctor, keeping in mind the severity of your condition and how well you respond to the medicine. Never change the prescribed dosage without consulting your doctor first. For further details regarding the dosage, kindly refer to the package insert.

Over Dose

Accidental overdose of Rapacan 1 Tablet may result in symptoms similar to its common side effects like joint pain, headache, and diarrhoea. If you suspect that you've taken more than the prescribed dosage, please inform your doctor about it.

Missed Dose

In case you forget to take Rapacan 1 Tablet at the scheduled time, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Never adjust your dosage without consulting your doctor.

Store Rapacan 1 Tablet at room temperature, no exceeding 30°C.
Protect it from bright light and moisture, keep it in a tightly closed container.
Keep this medicine out of reach of children.
Always check the expiry date before use; don't take if expired.

As Rapacan 1 Tablet is used for organ transplant management, maintain a balanced diet rich in fruits, vegetables, and whole grains to support overall health and recovery.
Since grapefruit juice can interfere with the working of sirolimus, avoid consuming it while you are on this medication.

Fact Box

Drug Category	mTOR Inhibitor
Therapeutic Category	Immunosuppressant
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Organ Rejection, Lymphangioleiomyomatosis

What is the purpose of Rapacan 1 Tablet?

Rapacan 1 Tablet is a medicine used to help prevent organ rejection in individuals who have had a kidney transplant.

How does Rapacan 1 Tablet work?

It contains sirolimus, an ingredient that reduces the body's immune response, helping to prevent the transplanted kidney from being attacked by the immune system.

Can I take Rapacan 1 Tablet with food?

You must take the medicine as directed by your doctor.

What should I avoid while taking Rapacan 1 Tablet?

Avoid grapefruit juice as it can increase sirolimus levels in your blood, leading to more side effects. Also, avoid live vaccines due to increased risk of infections.

What if I forget a dose of Rapacan 1 Tablet?

If you miss a dose, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule.

How long will I need to take Rapacan 1 Tablet after my kidney transplant?

The duration is determined by your doctor based on your personal needs and response to therapy; often, such medications are taken for the lifetime of the transplanted organ.

What should I do if I experience side effects while taking Rapacan 1 Tablet?

If you experience side effects, particularly severe or persistent ones, consult your doctor immediately; they may adjust your dosage or consider alternative treatment options if necessary.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 8 years

BDS, PGCAD, GMHE (IIM-B)

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Manufacturer details

20th K.M. Hosur Road, Electronics City, , Bengaluru, Karnataka, 560100

Country of origin: INDIA

References

DailyMed. (n.d.). SIROLIMUS - sirolimus tablet. Retrieved 1 April 2024, from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5df60452-2b16-4ce9-8c29-48798a59d718
U.S. Food and Drug Administration. (2010). Approval Letter - Rapamune. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2010/021110s055s057,021083s044,s047ltr.pdf
Sirolimus. (2024, November 21). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB00877

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