Sevelam 400 Tablet 10

Rencord Life Sciences Pvt Ltd

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Composition

Sevelamer (400 Mg)

Strength:

800 MG 400 MG

Sevelam-400 Tablet is primarily used to manage high blood phosphate levels (hyperphosphatemia) in adults with chronic kidney disease (CKD) who are undergoing dialysis. This medicine falls under the category of phosphate binders.

In addition to this principal use, this medicine helps prevent secondary hyperparathyroidism, a condition that can lead to bone problems due to elevated parathyroid hormone levels. It also aids in reducing the risk of complications such as calcification of soft tissues and blood vessels, which can occur due to high blood phosphate levels.

Before starting this medicine, it's crucial to consult your doctor for the correct dosage and frequency. Make sure you inform your doctor about any pre-existing conditions or ongoing medications. Should you notice any side effects while on this medicine, notify your doctor immediately. For optimal results, continue using the medicine for the duration prescribed by your doctor.

Sevelam-400 Tablet is used for the following:

Management of high blood phosphate levels in chronic kidney disease (CKD) patients on dialysis
Helping to reduce the risk of complications such as calcification of soft tissues and blood vessels
Assisting in the prevention of secondary hyperparathyroidism, a condition that can lead to bone problems

Directions for Use of Sevelam 400 Tablet 10

Here are some instructions while taking Sevelam-400 Tablet:

Swallow the tablet whole with a glass of water.
Avoid crushing, chewing, or breaking the tablet.
Never change your dosage without consulting your doctor first.
Remember not to stop taking this medicine without speaking to your doctor.

Sevelam-400 Tablet is taken orally.

Sevelam-400 Tablet may have the following common side effects:

Nausea
Vomiting
Diarrhoea
Abdominal pain
Constipation

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Sevelam-400 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: You could try taking Sevelam-400 Tablet with food.
Constipation: Increasing your water intake could help manage this side effect. Make sure to consult your doctor if it persists.

Sevelam-400 Tablet contains sevelamer (400 mg). This medicine works in the body in the following ways:

Binds to dietary phosphate: Sevelamer binds to the phosphate in your intestines, forming an insoluble complex.
Reduces blood phosphate levels: The complex formed is excreted from the body through your faeces. This reduces the amount of phosphate absorbed into your bloodstream, effectively lowering your blood phosphate levels.

Pregnancy

Caution is advised while taking Sevelam-400 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, it's important to discuss the use of Sevelam-400 Tablet with your doctor to understand potential risks and benefits.

Alcohol

There are no specific restrictions on the consumption of alcohol when taking Sevelam-400 Tablet. However, it's always a good idea to limit alcohol intake while on medication.

Liver

This medicine is often prescribed for older patients, who may be more susceptible to liver health issues. It is advisable to discuss liver-related concerns with your doctor before starting treatment with Sevelam-400 Tablet. They will evaluate if this medicine is suitable.

Kidney

As Sevelam-400 Tablet is used in managing high blood phosphate levels in patients with chronic kidney disease, it's crucial to discuss any kidney health issues with your doctor before starting this medication.

Using Machines & Driving

Sevelam-400 Tablet does not usually affect your ability to drive or operate machinery. However, if you experience any side effects that could impair these abilities, avoid these activities and consult your doctor.

Allergy

If you have any known allergies to sevelamer or any other component of Sevelam-400 Tablet, it's essential to inform your doctor before starting this medication.

Children

Sevelam-400 Tablet is meant for adult use. Always consult with a doctor before giving any medicine to a child.

Older Patients

Older patients should take Sevelam-400 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Older patients might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Sevelam-400 Tablet interacts with the following medicines:

Antibiotics: Sevelamer carbonate can decrease the absorption of ciprofloxacin, an antibiotic. This means that less ciprofloxacin may be available in your body to fight infections.
Thyroid Hormones: Sevelamer carbonate can decrease the absorption of levothyroxine, a thyroid hormone. This could lead to reduced effectiveness of your thyroid medication.
Immunosuppressants: Sevelamer carbonate can decrease the absorption of immunosuppressants like cyclosporine and mycophenolate. This could reduce their effectiveness in managing autoimmune conditions.

Drug-Food Interactions

Drug-Disease Interactions

Sevelam-400 Tablet interacts with the following diseases:

Hypophosphatemia: People with low blood phosphate levels should avoid taking Sevelam-400 Tablet as it can further lower their phosphate levels.
Bowel Obstruction: Patients with a bowel obstruction should not take Sevelam-400 Tablet as it could worsen their condition.
Dysphagia or Swallowing Disorders: Patients with swallowing disorders should exercise caution when taking this medication. It should be swallowed whole and not crushed or chewed.

Daily Dose

You should take your daily dose of Sevelam-400 Tablet exactly as prescribed by your doctor. The dosage may vary depending on factors like the severity of your condition and how you're responding to treatment. Please ensure not to exceed the prescribed dosage without consulting your doctor.

Over Dose

In case you took more than the prescribed dose of Sevelam-400 Tablet, you might experience symptoms like severe constipation, stomach pain, and vomiting. If these symptoms persist or worsen, inform your doctor.

Missed Dose

If you forget to take Sevelam-400 Tablet at the scheduled time, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular dosage schedule. Do not increase your dosage without consulting with your doctor.

Store your Sevelam-400 Tablet at room temperature, ideally below 30 degrees Celsius.
Keep the medicine away from high heat and moisture to ensure its effectiveness.
Always remember to keep this medicine out of sight and reach of children.
Make sure you use Sevelam-400 Tablet before its expiry date.

Since Sevelam-400 Tablet is used to manage high blood phosphate levels, you might find it beneficial to limit your intake of high-phosphate foods like dairy products, beans, lentils, and whole grains.
As this medicine is also intended for those with chronic kidney disease on dialysis, incorporating a low-sodium diet could help manage your condition. Remember to consult your doctor for detailed dietary recommendations.

Fact Box

Drug Category	Phosphate Binder
Therapeutic Category	Hyperphosphatemia Manager
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Kidney Disease, Hyperphosphatemia

What is Sevelam-400 Tablet used for?

Sevelam-400 Tablet is used to manage high blood phosphate levels in adults with chronic kidney disease who are on dialysis.

How does Sevelam-400 Tablet work?

This medication reduces phosphate absorption from your gut by creating a complex with dietary phosphate, which then leaves the body via stool.

Can I crush or chew Sevelam-400 Tablets?

No, you should swallow the tablet whole. Crushing or chewing it can interfere with its effectiveness.

What are the common side effects of Sevelam-400 Tablet?

Common side effects include nausea, vomiting, diarrhoea, abdominal pain and constipation. If you experience any serious side effects, consult your doctor immediately.

Are there any precautions I need to take while using Sevelam-400 Tablet?

If you have any pre-existing gastrointestinal disorders or a history of major gastrointestinal surgery before using this medicine, consult your doctor.

Can Sevelam-400 Tablet interact with other medicines?

Yes, it can reduce the absorption of certain medicines like ciprofloxacin and levothyroxine. Always consult your doctor before starting any new medication.

What should I do in case of overdose?

If you suspect an overdose of Sevelam-400 Tablet, seek immediate medical attention. Overdose symptoms may include severe constipation, abdominal pain and vomiting.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 9 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Office No. 156, 1st Floor, Vardhman Grand Plaza Commercial complex, Rohini, Sec.-3, New Delhi-110085

Country of origin: INDIA

References

Genzyme Corporation. (2000). Renvela prescribing information [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022127s011lbl.pdf
Renvela. (n.d.). Sevelamer Carbonate tablets and powder for oral suspension [Description]. https://www.sanofi.in/dam/jcr:c7b8bdab-5d5d-44ac-9617-1c8872d90fd3/Renvela%20Powder%20&%20Tabs%20PI%20rev%20Feb22.pdf
DailyMed - SEVELAMER HYDROCHLORIDE tablet, film coated. (n.d.). https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2cd6512f-0edd-4a30-a4fa-aa996038633c
Sevelamer: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00658
Sevelamer: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a601248.html

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