Simbrinza 102 Mg Eye Drops 5 Ml

Simbrinza Ophthalmic Suspension 5ml

Alcon Laboratories

Bottle of 5 ML

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MRP ~~₹710.00~~

₹582.20

₹142.00/ML

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Composition

Benzalkonium Chloride (0.003 %) + Brimonidine (0.2 %) + Brinzolamide (1 %)

Simbrinza Ophthalmic Suspension is used to lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. By combining two active ingredients, it helps reduce eye pressure and prevent optic nerve damage, which can lead to vision loss. This medication may be used alone or with other eye drops when necessary to maintain safe IOP levels and protect vision.

This version simplifies the language, highlights key benefits (vision protection and pressure reduction), and keeps the focus on patient outcomes."

It's essential to take this medicine as directed by your doctor. Before starting this medicine, it’s crucial to inform your doctor about any pre-existing conditions or ongoing medications to avoid potential interactions. If you notice any side effects while using these eye drops, immediately report them to your doctor. For optimal results, continue using the eye drops for the duration your doctor prescribes.

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Uses of Simbrinza Ophthalmic Suspension 5ml

Simbrinza Ophthalmic Suspension is used to treat elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It reduce eye pressure and prevent optic nerve damage, helping protect vision.

Directions for Use of Simbrinza Ophthalmic Suspension 5ml

Using Simbrinza Ophthalmic Suspension requires careful attention. Here's how you should proceed:

Shake well before use. This ensures that the contents are mixed properly.
Remember to directly instill the drops it into your eye and avoid touching your eye with the dropper tip.
If you're using more than one type of eye medication, wait at least 5 minutes between each one. This ensures that each medicine has enough time to be absorbed properly.
Before instilling, remember to remove any contact lenses you might be wearing. You can reinsert them 15 minutes after application.

Simbrinza Ophthalmic Suspension is applied topically.

Side Effects of Simbrinza Ophthalmic Suspension 5ml

Simbrinza Ophthalmic Suspension may have the following common side effects:

Blurred vision
Eye irritation
Dry mouth
Eye allergy
Dysgeusia: This means a bad taste in your mouth.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Simbrinza Ophthalmic Suspension. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of general guidelines for managing common side effects:

Blurred vision: If this medicine causes blurred vision during your daily activities, consider taking it at bedtime.
Dry mouth: To manage dry mouth caused by Simbrinza Ophthalmic Suspension, drink plenty of water throughout the day.

How Simbrinza Ophthalmic Suspension 5ml Works?

Simbrinza Ophthalmic Suspension contains two active ingredients that work together to reduce intraocular pressure:

Brinzolamide (1%): This component works by inhibiting an enzyme called carbonic anhydrase II in the ciliary epithelium of your eye. This inhibition results in a decrease in aqueous humour secretion, the fluid produced in your eye.
Brimonidine (0.2%): Brimonidine operates by decreasing the production of aqueous humour and increasing its outflow through a pathway known as uveoscleral outflow.

Pregnancy

Caution is advised while taking Simbrinza Ophthalmic Suspension if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

Simbrinza Ophthalmic Suspension should be used with caution if you are breastfeeding as brimonidine may be excreted in human milk. It's advisable to discuss this with your doctor.

Alcohol

The interaction of Simbrinza Ophthalmic Suspension with alcohol is not well established. It's better to consult your doctor for advice on this matter.

Liver

If you have any liver health issues, it's recommended to consult your doctor before starting Simbrinza Ophthalmic Suspension. They will evaluate if this medicine is suitable for you.

Kidney

For those with any kidney health concerns, it's advised to discuss these with your doctor before starting Simbrinza Ophthalmic Suspension, especially as caution is needed in severe renal impairment cases.

Using Machines & Driving

Simbrinza Ophthalmic Suspension may cause blurred vision which could affect your ability to drive or operate machinery. It's safer to avoid such activities until you know how the medicine affects you.

Allergy

Simbrinza Ophthalmic Suspension is contraindicated for those who are allergic to any of its components, including benzalkonium chloride, brinzolamide, or brimonidine.

Children

Safety and efficacy of Simbrinza Ophthalmic Suspension in children below 2 years have not been established. Always consult your doctor before giving this medicine to a child.

Older Patients

No major differences have been observed in the safety or effectiveness of Simbrinza Ophthalmic Suspension in older patients. However, older patients may be more susceptible to side effects and should use the medicine under medical supervision.

Interactions of Simbrinza Ophthalmic Suspension 5ml

Drug-Drug Interactions

Simbrinza Ophthalmic Suspension interacts with the following medicines:

Alpha-2 Agonists (e.g., apraclonidine): Combining similar medications can increase the risk of systemic side effects such as drowsiness, fatigue, or dry mouth.
Carbonic Anhydrase Inhibitors (e.g., dorzolamide): Concurrent use may amplify systemic effects, like metabolic acidosis, particularly in individuals with renal impairment.

Drug-Food Interactions

Simbrinza Ophthalmic Suspension does not have any known interactions with specific foods. However, always follow your doctor's advice regarding a healthy diet while on medication.

Drug-Disease Interactions

Simbrinza Ophthalmic Suspension interacts with the following diseases:

Asthma and severe Chronic Obstructive Pulmonary Disease (COPD): If you have these conditions, Simbrinza Ophthalmic Suspension could cause breathing difficulties.
Sinus bradycardia and AV block: Patients with these heart conditions should exercise caution as this medicine can affect heart rate.
Severe renal impairment and hepatic insufficiency: Use of Simbrinza Ophthalmic Suspension should be carefully monitored in patients with these conditions due to potential changes in medicine metabolism.
Depression, cerebral or coronary insufficiency, Raynaud's phenomenon: Caution is recommended when using this medicine in patients suffering from these conditions due to the potential for increased systemic side effects.

Dosage of Simbrinza Ophthalmic Suspension 5ml

Daily Dose

The daily dosage of Simbrinza Ophthalmic Suspension should be administered as directed by your doctor. This can vary based on individual circumstances, like how severe your condition is and how well you respond to the medicine. Always stick to the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

Although overdosing on eye drops is unlikely, if you accidentally instill more drops than recommended, don't worry. Just rinse your eyes with room temperature water. If symptoms persist or get worse, inform your doctor.

Missed Dose

If you forget to instill Simbrinza Ophthalmic Suspension at the scheduled time, do so as soon as you remember. However, if it's almost time for your next dose, skip the missed one and go back to your regular dosing schedule. Never double up your dosage without speaking to your doctor first.

Store Simbrinza Ophthalmic Suspension in a cool, dry place; the ideal temperature is below 30°C.
Keep it away from direct sunlight.
Always ensure the product is kept out of the reach of children.
Use it before its expiry date.
Discard any remaining suspension four weeks after first opening.

Regular eye exercises can help manage ocular hypertension and glaucoma. These exercises can promote better circulation to your eyes, helping to ease pressure.
Maintain a healthy diet rich in fruits and vegetables, especially those high in antioxidants like Vitamin C and E. These nutrients can support overall eye health, potentially helping to manage conditions like open-angle glaucoma or ocular hypertension.

Fact Box

Drug Category	Carbonic Anhydrase Inhibitor, Alpha-2 Adrenergic Receptor Agonist
Therapeutic Category	Anti-Glaucoma
Available Dosage Types	Eye Drops
Habit Forming	No
Ailment	Open-Angle Glaucoma, Ocular Hypertension

What is Simbrinza Ophthalmic Suspension used for?

Simbrinza Ophthalmic Suspension helps to lower high pressure inside the eye, often experienced by those with open-angle glaucoma or ocular hypertension.

How does Simbrinza Ophthalmic Suspension work?

The medicine reduces eye pressure by decreasing fluid production and increasing fluid outflow in the eye, thanks to its two active ingredients: brimonidine and brinzolamide.

How should I use Simbrinza Ophthalmic Suspension?

You should put the drops as advised by your doctor.

Can I wear contact lenses while using this medicine?

Yes, but you should remove your lenses prior to instilling the drops and wait 15 minutes before reinserting them.

Are there any side effects of Simbrinza Ophthalmic Suspension?

Common side effects include blurred vision, eye irritation, bad taste, dry mouth, and eye allergies. Rare but serious side effects can include slow heart rate and drowsiness.

Are there any precautions I should take while using this medicine?

Avoid using Simbrinza Ophthalmic Suspension if you have severe asthma, serious lung disease, slow heart rate, or certain heart conditions. Also use caution if you have renal or hepatic impairment.

What should I do in case of an overdose?

In case of an overdose, you may experience low blood pressure or slow breathing rate. Seek immediate medical help if these symptoms occur.

Last Updated On 06 Dec. 2024 | 11:32AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

163, Udyog Bhavan, 1st Floor, Sonawala Road, Goregaon East, Mumbai - 400063

Country of origin: INDIA

References

Azopt® (brinzolamide ophthalmic suspension) 1%. (n.d.). https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020816s009lbl.pdf
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS. (n.d.). Retrieved November 15, 2024, from https://ec.europa.eu/health/documents/community-register/2022/20220624155864/anx_155864_en.pdf
Brinzolamide: Uses, Interactions, Mechanism of Action | DrugBank Online. (2020); DrugBank. https://go.drugbank.com/drugs/DB01194
Brimonidine: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00484
PubChem. (n.d.). Brimonidine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Brimonidine
Brimonidine ophthalmic: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a601232.html

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