Spegra Tablet 30

Emcure Pharmaceuticals Ltd

BOTTLE of 30 Units
STRIP of 10 Units

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MRP ~~₹4388.50~~

₹3576.63

₹146.28/Units

18.5% off

*MRP inclusive of all taxes

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Composition

Dolutegravir (50 Mg) + Emtricitabine (200 Mg) + Tenofovir Alfenamide (25 Mg)

Spegra Tablet is primarily used as a complete treatment regimen for HIV-1 infection in adults and children. This medication belongs to the classes of integrase strand transfer inhibitors (INSTIs) and nucleoside reverse transcriptase inhibitors (NRTIs).

It also helps in restoring and maintaining immune function by reducing viral load.

Before starting this medication, consult your doctor about the proper dosage and ensure that any pre-existing medical conditions or current medications are disclosed. If any side effects occur, notify your doctor promptly. For optimal results, continue taking this medication as prescribed.

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Spegra Tablet is used in the following conditions:

HIV-1 Treatment: A complete regimen for treating HIV-1 infection in adults and children.
Immune Function Improvement: Helps in restoring and maintaining immune function by reducing viral load.

Take this tablet with or without food.
Swallow the tablet whole with water; do not crush or chew it.
Always follow your doctor’s prescribed dosage instructions.

Spegra Tablet is taken orally.

Spegra Tablet may cause the following side effects:

Headache
Nausea
Diarrhea
Fatigue
Abdominal pain

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Spegra Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some general guidelines for managing common side effects:

Headache: Stay hydrated and rest in case of headache.
Nausea: Take the tablet with food to prevent nausea.
Diarrhea: Stay hydrated by drinking fluids.

Spegra Tablet works by combining three components:

Dolutegravir (50 mg): It inhibits the action of integrase, an enzyme essential for the HIV virus to multiply and spread. By blocking this enzyme, it prevents the virus from integrating its genetic material into healthy human cells.
Emtricitabine (200 mg): A reverse transcriptase inhibitor, Emtricitabine blocks the enzyme that HIV uses to convert its RNA into DNA. This prevents the virus from creating new copies of itself.
Tenofovir Alafenamide (25 mg): It hinders the virus's ability to incorporate itself into healthy cells, effectively stopping the spread of HIV in the body.

Pregnancy

Spegra Tablet is not recommended during pregnancy unless deemed essential by a healthcare provider, as some components may harm the developing baby.

Breastfeeding

Avoid breastfeeding while taking Spegra Tablet due to the risk of passing this medication to the baby through breast milk.

Alcohol

Avoid alcohol while taking Spegra Tablet, as it may exacerbate side effects like nausea or dizziness.

Liver

Use Spegra Tablet cautiously if you have existing liver disease, including hepatitis B or C. Regular liver function tests may be required. Your doctor will guide you based on your health status.

Kidney

This tablet is not recommended for individuals with severe renal impairment. Inform your doctor before this tablet is prescribed to you.

Using Machines & Driving

Spegra Tablet may cause dizziness or fatigue. Avoid driving or operating machinery until you know how it affects you.

Allergy

Do not use this medication if you are allergic to any of its components, including dolutegravir, emtricitabine, or tenofovir. Symptoms of an allergic reaction include rash, fever, or swelling.

Children

This tablet is not recommended for children weighing less than 40 kg. Your doctor will guide you on dosage depending on your child’s age and weight.

Older Patients

Elderly patients may be more susceptible to side effects. Dose adjustments may be required. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Spegra Tablet can interact with the following medications:

Antiarrhythmic such as Dofetilide: Spegra Tablet is contraindicated with dofetilide due to the risk of severe side effects, such as life-threatening arrhythmias.
Antibiotics such as Rifampin: This medicine can reduce the effectiveness of dolutegravir by lowering its concentration in the blood.
Anticonvulsants such as Carbamazepine and Phenobarbital: These medicines can also reduce the blood levels of the active ingredients in Spegra Tablet, potentially diminishing its effectiveness.

Drug-Food Interactions

There are no specific food restrictions for Spegra Tablet.

Drug-Disease Interactions

Spegra Tablet can interact with the following conditions:

Kidney or Liver Impairment: Use Spegra Tablet cautiously in patients with kidney or liver problems, as these conditions can affect how the medication is processed in the body. Regular monitoring of liver and kidney function is recommended.

Daily Dose

The daily dose of Spegra Tablet should be taken as advised by your doctor. The dosage may vary based on factors such as the severity of your condition and how you respond to the medicine. Always follow the dosage prescribed by your doctor and avoid exceeding it without consultation.

Over Dose

If more than the recommended dose is taken, seek medical attention immediately. Symptoms of overdose may include dizziness, nausea, or increased side effects.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose. Do not double the dose.

Store at room temperature (15°C-30°C) away from direct sunlight and moisture.
Keep out of reach of children.

Fact Box

Drug Category	Antiretroviral
Therapeutic Category	HIV Treatment
Available Dosage Types	Tablet
Habit Forming	No
Ailment	HIV-1 Infection

What is Spegra Tablet used for?

Spegra Tablet is primarily used to treat HIV-1 infection in adults and adolescents weighing at least 40 kg. It helps control the virus, reducing the viral load and boosting immune function.

How does Spegra Tablet work?

Spegra Tablet contains three active ingredients—Dolutegravir, Emtricitabine, and Tenofovir Alafenamide—that work together to inhibit the replication and spread of HIV within the body. By targeting different stages of the viral life cycle, this combination effectively suppresses the virus.

Are there any precautions for Spegra Tablet?

This tablet should be used cautiously in patients with liver or kidney issues. Pregnant women and breastfeeding mothers should avoid using Spegra Tablet unless specifically prescribed by their doctor.

Can Spegra Tablet interact with other medicines?

Yes, it interacts with medicines like dofetilide, rifampin, and anticonvulsants. Inform your doctor about all current medications.

What are the side effects of Spegra Tablet?

Common side effects include headache, nausea, diarrhoea, and abdominal pain. Serious side effects like liver damage or hypersensitivity reactions are rare but require immediate medical attention.

Last Updated On 03 Jan. 2025 | 10:23AM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

Emcure House, T 184, M.I.D.C. Bhosari, Pune 411026

Country of origin: INDIA

References

Dolutegravir, Emtricitabine and Tenofovir Alafenamide tablets. Fda.Gov. Retrieved December 30, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/210237PI.pdf
DOLUTEGRAVIR, EMTRICITABINE and TENOFOVIR tablets. Fda.Gov. Retrieved December 30, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/213681PI.pdf
Dolutegravir, Emtricitabine and Tenofovir Alafenamide Tablets. Gov.Et. Retrieved December 30, 2024, from http://www.efda.gov.et/wp-content/uploads/2023/12/Dolutegravir-Emtricitabine-Tenofovir-Alafenamide-Tablets-50-mg-200-mg-25-mg.pdf

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