Sulfasalaz 1000 Mg Tablet 15

Sulfasalaz 1000 Tablet 15

Steris Healthcare

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Composition

Sulfasalazine (1000 Mg)

Strength:

500 MG 1000 MG

Sulfasalaz 1000 Tablet is primarily used to manage ulcerative colitis, a condition that inflames and forms sores in your colon and rectum. It's part of the aminosalicylates class of medicines known for their inflammation-reducing effects.

In addition to managing ulcerative colitis, it is also used to manage rheumatoid arthritis in adults and children. Rheumatoid arthritis is an inflammatory disease that causes pain, swelling and stiffness in your joints.

This medicine should be taken orally, as directed by your doctor. Before starting this medication, it's essential to inform your doctor about any pre-existing conditions or ongoing medicines you're using. If you notice any side effects while on this medicine, notify your doctor right away. For optimal results, continue taking the tablet for the duration prescribed by your doctor.

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Sulfasalaz 1000 Tablet is used for the following:

Management of ulcerative colitis: This condition causes swelling and sores in the lining of your colon and rectum.
Managing rheumatoid arthritis: This is a chronic inflammatory disorder that can affect your joints and cause painful swelling.

Directions for Use of Sulfasalaz 1000 Tablet 15

Here's how you should take Sulfasalaz 1000 Tablet:

Swallow the tablet whole with plenty of water.
It is best to take this medicine with food to reduce the possibility of an upset stomach.
Do not crush or chew the tablet.
The dose will depend on your condition, so it's important to follow your doctor's advice on how many tablets to take.
Always remember, you should not stop taking this medicine without consulting your doctor.

Sulfasalaz 1000 Tablet is taken orally.

Side Effects of Sulfasalaz 1000 Tablet 15

Sulfasalaz 1000 Tablet may have the following common side effects:

Nausea
Vomiting
Loss of appetite
Headache
Dizziness
Orange-yellow discolouration of skin and body fluids: This medicine can cause a temporary change in the colour of your skin or bodily fluids.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Sulfasalaz 1000 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Try taking Sulfasalaz 1000 Tablet with food to lessen this effect.
Loss of appetite: Consider taking this medicine at meal times to encourage consistent eating habits.

Sulfasalaz 1000 Tablet contains sulfasalazine (1000 mg) and works on the body as follows:

Unchanged Passage Through Stomach: Sulfasalazine doesn't change when it passes through your stomach.
Conversion into Active Components: In your intestines, bacteria break down sulfasalazine into two parts: sulfapyridine and 5-aminosalicylic acid (5-ASA/mesalamine).
Anti-inflammatory Effect in Colon: The 5-ASA component provides an anti-inflammatory effect in the colon, helping reduce inflammation and sores associated with ulcerative colitis.
Anti-rheumatic Effect: Sulfapyridine is absorbed into your body and is believed to be responsible for reducing symptoms of rheumatoid arthritis. However, the exact way it works isn't fully understood yet.

Pregnancy

Caution is advised while taking Sulfasalaz 1000 Tablet during pregnancy. It is best to consult your doctor before taking this medicine.

Breastfeeding

Sulfasalaz 1000 Tablet should be used with caution while breastfeeding, as it is excreted in breast milk. Consult your doctor to understand the potential risks and benefits.

Alcohol

Sulfasalaz 1000 Tablet doesn't interact with alcohol, but it's advisable to consult your doctor before consumption, as excess alcohol intake can lead to inflammation in the body.

Liver

If you have liver problems, discussing them with your doctor before starting Sulfasalaz 1000 Tablet is a good idea. This medicine should be used cautiously in patients with impaired liver function.

Kidney

Caution is advised before using Sulfasalaz 1000 Tablet if you have a history of kidney problems. It would be beneficial to consult your doctor before taking this medicine.

Using Machines & Driving

The effect of the Sulfasalaz 1000 Tablet on your ability to drive or operate machinery is not known. If you notice any symptoms that could affect these activities, seek medical advice promptly.

Allergy

Sulfasalaz 1000 Tablet is contraindicated for patients with known hypersensitivity to sulfasalazine, its metabolites, sulfonamides, or salicylates. If you have a severe allergy, discuss this with your doctor before starting this medicine.

Children

Sulfasalaz 1000 Tablet is not safe for use by children under six years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Elderly patients may be more susceptible to the side effects of Sulfasalaz 1000 Tablet. Use with caution and under medical supervision if you are over 70 years of age. Your doctor will guide you based on your overall health status.

Interactions of Sulfasalaz 1000 Tablet 15

Drug-Drug Interactions

Sulfasalaz 1000 Tablet interacts with the following medicines:

Folic acid supplements: Sulfasalaz 1000 Tablet may decrease the absorption of folic acid from supplements.
Immunosuppressants like azathioprine: There is an increased risk of blood disorders when these medicines are taken with Sulfasalaz 1000 Tablet.
Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen may increase the risk of toxicity when taken with Sulfasalaz 1000 Tablet.

Drug-Food Interactions

Sulfasalaz 1000 Tablet can interact with certain foods:

High-protein foods: Avoid consuming large amounts of protein while taking this medication, as it may interfere with its absorption.

Drug-Disease Interactions

Sulfasalaz 1000 Tablet interacts with the following diseases:

Intestinal or Urinary Obstruction: Sulfasalaz 1000 Tablet should not be used in patients with intestinal or urinary obstructions due to the risk of worsening their condition.
Blood Disorders: Patients with blood disorders should be cautious while taking Sulfasalaz 1000 Tablet, as there is a risk of developing further complications.
Impaired Kidney or Liver Function: Sulfasalaz 1000 Tablet should be used with caution in patients with impaired kidney or liver functions, as it may worsen their condition.

Daily Dose

The daily dosage of Sulfasalaz 1000 Tablet should be strictly as per your doctor's advice. This dosage may vary based on the severity of your condition and how you respond to the medicine. Always follow your doctor's prescribed dosage and refrain from exceeding it without consulting your doctor first.

Over Dose

Overdosing on Sulfasalaz 1000 Tablet could cause nausea, vomiting, abdominal discomfort, and diarrhoea. If you realise you have taken more than the prescribed dose, let your doctor know right away.

Missed Dose

If you forget to take a dose of Sulfasalaz 1000 Tablet, take it as soon as you remember. However, if it's close to the time for your next dose, simply skip the missed one and go back to your usual schedule. Never increase your dosage without consulting your doctor.

Store your Sulfasalaz 1000 Tablet in a cool, dry place between 20°C and 25°C.
Protect the medicine from light and moisture to maintain its effectiveness.
Keep it out of the reach and sight of children to prevent accidental ingestion.
Check the expiration date on the package, and do not use the medicine after that date.

If you're managing ulcerative colitis with Sulfasalaz 1000 Tablet, consider limiting dairy products as they could worsen diarrhoea symptoms. Consult your doctor for personalised dietary advice.
For those using this medicine to manage rheumatoid arthritis, regular low-impact exercises like swimming or cycling can help keep your joints flexible. Always consult your doctor before starting any new exercise regimen.

Fact Box

Drug Category	Aminosalicylates
Therapeutic Category	Anti-inflammatory
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Rheumatoid arthritis

What Is Sulfasalaz 1000 Tablet Used For?

Sulfasalaz 1000 Tablet is used to manage ulcerative colitis and rheumatoid arthritis, both inflammatory conditions.

How Does Sulfasalaz 1000 Tablet Work?

This medicine reduces inflammation by being split into two components in the gut, one of which has anti-inflammatory effects.

Can Sulfasalaz 1000 Tablet Cause Allergic Reactions?

Yes, it can cause serious allergic reactions. If you observe any signs of an allergic reaction, stop taking it and consult your doctor immediately.

How Should I Take Sulfasalaz 1000 Tablet?

The tablet should be taken orally and swallowed whole with water. Taking it with food can help prevent stomach upsets.

Will Sulfasalaz 1000 Tablet Change the Colour of My Urine or Skin?

Yes, it can turn urine and skin orange-yellow. This is a common side effect and is not harmful.

Can I Take Other Medicines Alongside Sulfasalaz 1000 Tablet?

Some medications may interact with sulfasalazine; therefore, always consult your doctor before taking any other medication.

What Should I Do If I Miss a Dose of Sulfasalaz 1000 Tablet?

If you miss a dose, take it as soon as you remember, unless it's almost time for the next dose. Avoid double dosing.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Tanaji Chowk, Ambedkar Nagar, Kurla West, Kurla, Mumbai, Maharashtra 400070

Country of origin: INDIA

References

Unknown. (n.d.). Azulfidine [Book]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/007073s124lbl.pdf
Sulfasalazine: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00795
Choi, J., Patel, P., & Fenando, A. (2024, March 21). Sulfasalazine. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK557809/
Suarez-Almazor, M. E., Belseck, E., Shea, B., Tugwell, P., & Wells, G. A. (1998). Sulfasalazine for treating rheumatoid arthritis. Cochrane Library. https://doi.org/10.1002/14651858.cd000958
Mushtaq, S., & Sarkar, R. (2020). Sulfasalazine in dermatology: A lesser explored drug with broad therapeutic potential. International Journal of Women’s Dermatology, 6(3), 191–198. https://doi.org/10.1016/j.ijwd.2020.01.009
Taffet, S. L., & Das, K. M. (1983). Sulfasalazine. Digestive Diseases and Sciences, 28(9), 833–842. https://doi.org/10.1007/bf01296907

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