Susten 8 Gel 135 Gm

Susten 8.0% Gel 1.35gm

Sun Pharma Laboratories Ltd.

Tube of 1.35 GM

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MRP ~~₹175.00~~

₹143.50

₹129.63/GM

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Composition

Natural Micronised Progesterone (8 %)

Susten 8.0% Gel is primarily utilised for managing infertility issues, particularly those associated with progesterone deficiency during assisted reproductive technology (ART) procedures. This medicine is part of a group known as progestogens, which are synthetic versions of the naturally occurring female hormone, progesterone.

A secondary application of this gel is the management of secondary amenorrhoea, which is described as the absence of menstrual periods in women. The use of this gel can help re-establish regular menstrual cycles by initiating progesterone withdrawal.

Susten 8.0% Gel is used for the following:

Assisting in infertility treatment by supplementing or replacing progesterone in women undergoing assisted reproductive technology (ART) procedures.
Managing secondary amenorrhoea, which is the absence of menstrual periods in women.

Directions for Use of Susten 8.0% Gel 1.35gm

Administer Susten 8.0% Gel as follows:

Make sure to use the disposable applicators provided with the medicine.
Apply the gel directly into your vagina, preferably either in the morning or at bedtime.
Always consult your doctor for specific advice on how to use this medicine properly.

Susten 8.0% Gel is applied vaginally.

Using Susten 8.0% Gel might produce a few common side effects, such as:

Vaginal discharge or irritation
Breast tenderness or pain
Nausea
Headache
Bloating or abdominal cramps
Drowsiness
Fatigue
Urinary problems
Constipation
Diarrhoea

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Susten 8.0% Gel. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some suggestions to manage a couple of these common side effects:

Nausea: Try taking Susten 8.0% Gel with meals to minimise feelings of nausea.
Drowsiness or fatigue: If you feel sleepy or tired after using the gel, consider using it at bedtime.

The main component in Susten 8.0% Gel is natural micronised progesterone (8%), which works on your body as follows:

Endometrium Conversion: Progesterone converts the endometrium (the lining of your uterus) from a proliferative to a secretory state, making it receptive to embryo implantation.
Uterine Contractility Inhibition: The activity of progesterone inhibits uterine contractility, supporting early pregnancy.
Negative Feedback Effect: Progesterone has a negative feedback effect on the hypothalamus and pituitary gland in your brain, suppressing the secretion of gonadotropin hormones.

Pregnancy

Susten 8.0% Gel is widely used to manage infertility and support early pregnancy. However, if you are pregnant and your doctor has not prescribed this medicine, caution is advised. Always consult your doctor before using this medicine.

Breastfeeding

This medicine is considered safe during breastfeeding as its systemic absorption is low when applied vaginally. However, always consult your doctor before using Susten 8.0% Gel while breastfeeding.

Alcohol

There are no known interactions between alcohol and the use of Susten 8.0% Gel. Nonetheless, it's always wise to limit your alcohol consumption for overall wellness.

Liver

Susten 8.0% Gel is advised against use for those with liver disease or significant liver dysfunction, as progesterone is metabolised by the liver. If you have liver health issues, it's crucial to consult your doctor before using this medicine.

Kidney

No specific interaction between Susten 8.0% Gel and kidney health has been reported. Still, if you have a history of kidney problems, it's recommended to discuss this with your doctor before starting the medicine.

Using Machines & Driving

Susten 8.0% Gel may cause drowsiness or fatigue in some users, which could affect your ability to operate machinery or drive safely. It's advisable to monitor how you react to the medicine before performing these activities.

Allergy

If you're allergic to progesterone or any other ingredients in Susten 8.0% Gel, avoid using this medicine as it can cause severe allergic reactions.

Children

This medicine is intended for adult use only and should not be given to children under 18 years of age without medical advice.

Older Patients

Elderly patients should use Susten 8.0% Gel under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Susten 8.0% Gel can interact with the following medicines:

Anticonvulsants like phenytoin or carbamazepine may interact with Susten 8.0% Gel, which could potentially decrease the effectiveness of the gel.
Rifampin: This antibiotic medicine used for tuberculosis treatment might reduce the effectiveness of this gel.
St. John's Wort: This herbal supplement can interfere with the effectiveness of Susten 8.0% Gel, potentially leading to lower therapeutic effects.
Ketoconazole: This antifungal medication can potentially increase progesterone levels when used alongside this gel.

Drug-Food Interactions

There are no known specific food interactions with Susten 8.0% Gel.

Drug-Disease Interactions

Susten 8.0% Gel can interact with the following diseases:

Liver Disease: Women suffering from liver disease or dysfunction should avoid using Susten 8.0% Gel, as progesterone is metabolised by the liver and its use may exacerbate liver conditions.
Breast or Genital Tract Malignancy: Women diagnosed with breast cancer or genital tract malignancies should not use this gel due to potential hormone-sensitive tumour growth.
Thromboembolic Disorders: Individuals having active thromboembolic disorders should avoid using this gel. Progesterone may increase the risk of blood clots in these individuals.

Daily Dose

Your doctor will prescribe the exact dosage of Susten 8.0% Gel you should apply daily. This can vary depending on individual factors such as the severity of your condition and your response to the medication. It's crucial to stick to the prescribed dosage without exceeding it unless your doctor advises otherwise.

Over Dose

Applying more than the instructed amount of Susten 8.0% Gel could lead to some common side effects becoming more pronounced. These may include breast tenderness and vaginal discharge. If you notice these or any other symptoms worsening, please consult your doctor.

Missed Dose

If you forget to apply Susten 8.0% Gel as advised, do it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never apply extra gel without discussing with your doctor first.

Store Susten 8.0% Gel in a cool place.
Keep the product in a dry place, away from direct sunlight and heat.
Do not refrigerate or freeze the gel.
Always keep this medicine out of children's reach.
Use the gel before the expiry date mentioned on the packaging.

If you're using Susten 8.0% Gel for infertility treatment, maintain a balanced diet rich in fruits, vegetables and lean proteins to support your overall reproductive health.
For managing secondary amenorrhoea, regular, moderate exercise can help regulate hormonal balance and menstrual cycles. However, it's essential to consult your doctor before starting any new exercise regime.

Fact Box

Drug Category	Hormonal Supplement
Therapeutic Category	Gynaecological Medicine
Available Dosage Types	Vaginal Gel
Habit Forming	No
Ailment	Infertility, Secondary Amenorrhoea

What is Susten 8.0% Gel used for?

The gel is primarily used to manage infertility and secondary amenorrhoea, which is the absence of menstrual periods in women.

How does Susten 8.0% Gel work?

It delivers progesterone to the uterine lining, preparing it for embryo implantation and maintaining early pregnancy.

Can I use other vaginal products with Susten 8.0% Gel?

Other vaginal products may affect progesterone absorption. Consult your doctor before using any additional products.

Is it safe to use Susten 8.0% Gel during breastfeeding?

Yes, as progesterone has low systemic absorption when administered vaginally, it's considered safe during lactation. It is always recommended to check with your doctor before using this gel.

What if I miss a dose of Susten 8.0% Gel?

If you miss a dose, apply as soon as remembered unless it's time for the next one; avoid double doses of this medication.

Can Susten 8.0% Gel be used by women with liver problems?

Women with liver diseases should refrain from using this gel as progesterone can further impair liver function. Always consult with your doctor before using this medication to address any liver concerns.

What are some common side effects of Susten 8.0% Gel?

Some common side effects include vaginal irritation, breast tenderness, nausea, headaches, bloating, drowsiness, urinary problems and constipation or diarrhoea. Seek medical attention if these symptoms persist or worsen.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Saniya K Mulla

Medical Writer & Reviewer | 5 years

MBBS

Check out Editorial Policy

Manufacturer details

SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

References

U.S. National Library of Medicine. (n.d.). DailyMed - CRINONE- progesterone gel. Retrieved from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=75e97aa1-daa4-45f9-b2e2-1a371302914e
Progesterone: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.-c). DrugBank. https://go.drugbank.com/drugs/DB00396
Progesterone: MedlinePlus Drug Information. (n.d.). https://medlineplus.gov/druginfo/meds/a604017.html
Malik, S., & Malik, S. (2016). Natural Micronized Progesterone Sustained Release (SR) and Luteal Phase: Role Redefined!! Journal of Clinical and Diagnostic Research. https://doi.org/10.7860/jcdr/2016/17278.7212
PubChem. (n.d.-bk). Progesterone. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/progesterone

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