Syldo 8d Capsule 10

Wallace Pharmaceuticals Ltd.

Strip of 10 Units

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MRP ~~₹468~~

₹233.53

₹46.80/Units

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Composition

Dutasteride (0.5 Mg) + Silodosin (8 Mg)

Syldo 8d Capsule 10 is primarily used to manage symptoms of benign prostatic hyperplasia (BPH) in adult men, a condition in which the prostate gland enlarges. This medicine is a combination medication containing two active ingredients.

This capsule alleviates BPH symptoms and improves urinary flow by relaxing certain muscles in the body. It addresses both the static and dynamic components of BPH, providing relief from uncomfortable conditions associated with an enlarged prostate.

Before taking this medicine, inform your doctor about any pre-existing diseases or ongoing medications. Any side effects noticed while on this medication should be immediately reported to your doctor. For optimum results and complete recovery, continue taking this medicine for the duration prescribed by your doctor.

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Syldo 8d Capsule 10 is used for the following:

Managing symptoms of benign prostatic hyperplasia in adult males with an enlarged prostate
Providing symptomatic relief by reducing the size of the prostate over time
Improving urinary symptoms through muscle relaxation in the prostate and bladder neck

Directions for Use of Syldo 8d Capsule 10

To use Syldo 8d Capsule 10, follow these steps:

Follow the dosage instructions given by your doctor.
Swallow the capsule whole without crushing, chewing, or opening it.

Syldo 8d Capsule 10 is taken orally.

While taking Syldo 8d Capsule 10, you might experience some of the following side effects:

Nasal congestion
Dizziness
Diarrhoea
Headache
Low blood pressure happens when you stand up from sitting or lying down
Inflammation of the nose and throat areas

Managing the Side Effects:

Most side effects are temporary and generally harmless, resolved by discontinuing Syldo 8d Capsule 10. However, if you experience serious side effects or worsening symptoms, please consult your doctor.

Here are a couple of tips for managing some common side effects:

Dizziness: If this medicine causes dizziness, consider taking it at bedtime.
Diarrhoea: Take Syldo 8d Capsule 10 with food or milk to lessen this effect.

Syldo 8d Capsule 10 contains two active ingredients:

Silodosin (8 mg): As an alpha-blocker, silodosin relaxes the prostate and bladder neck muscles. It selectively antagonises alpha-1 adrenoreceptors located in these tissues, leading to improved urinary flow and reduced symptoms of BPH.
Dutasteride (0.5 mg): This component works as a selective inhibitor of both type 1 and type 2 isoforms of 5α-reductase, an enzyme crucial in converting testosterone to dihydrotestosterone (DHT). DHT is mainly responsible for prostate growth; hence, by lowering DHT levels in the prostate, dutasteride helps shrink the prostate and improves BPH symptoms.

Alcohol

The interaction of alcohol with this medication is unknown. It's advisable to restrict alcohol consumption while taking Syldo 8d Capsule 10. If you regularly drink alcohol, please consult your doctor.

Liver

If you have mild to moderate liver problems, caution is advised when taking Syldo 8d Capsule 10. This medicine should not be taken if you have severe liver disease as it may affect liver function. Discuss your liver health with your doctor before starting this medication.

Kidney

This medication should not be used if you have severe kidney problems. If you have a history of kidney issues, it's a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

Since Syldo 8d Capsule 10 can cause dizziness, caution is recommended while driving or operating machinery until you know how the medication affects you. Please consult with your doctor for the best advice.

Allergy

Avoid using Syldo 8d Capsule 10 if you are allergic to dutasteride or silodosin. Always inform your doctor about any known allergies before starting this medicine.

Children

Syldo 8d Capsule 10 is not recommended for children under 18. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take this medicine under medical supervision as they may be more susceptible to its side effects and may have liver and kidney issues. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Syldo 8d Capsule 10 interacts with the following medicines:

CYP3A4 Inhibitors: Medicines like ketoconazole and ritonavir can increase the levels of dutasteride and silodosin in your blood when taken with Syldo 8d Capsule 10.
Alpha-blockers: Other alpha-blockers, such as tamsulosin or terazosin, together with Syldo 8d Capsule 10, can heighten the risk of experiencing low blood pressure or fainting.
Antihypertensive Agents: Medicines for managing high blood pressure, like amlodipine or metoprolol, may increase the risk of low blood pressure when taken alongside Syldo 8d Capsule 10.
PDE5 Inhibitors: Medicines like sildenafil or tadalafil can strengthen the blood pressure-lowering effect of Syldo 8d Capsule 10.

Drug-Food Interactions

Syldo 8d Capsule 10 has no known specific interactions with food. It is recommended that you take this medicine with a meal.

Drug-Disease Interactions

Syldo 8d Capsule 10 interacts with the following diseases:

Renal Impairment: Individuals with moderate kidney disease should take a lower dose of Syldo 8d Capsule 10, while those with severe kidney disease should avoid it altogether.
Hepatic Impairment: Syldo 8d Capsule 10 should not be consumed by individuals suffering from severe liver disease.
Hypotension: People with low blood pressure need to be careful while taking this medicine, as it may further reduce their blood pressure.
Prostate Cancer: There's an increased risk of high-grade prostate cancer associated with the use of dutasteride, one of the components of Syldo 8d Capsule 10.

Daily Dose

The daily dose of Syldo 8d Capsule 10 is to be taken as directed by your doctor. The dosage can vary depending on factors like the severity of your condition and how you respond to the medicine. Always adhere to the dosage prescribed and never increase it without consulting your doctor.

Over Dose

In case of an overdose, you might experience common side effects in a more severe form. If you suspect you have taken more than the prescribed dose, inform your doctor immediately. Never adjust your dosage without consulting your doctor.

Missed Dose

If you forget to take Syldo 8d Capsule 10 at the scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed dose and continue with your regular dosage schedule. Do not increase your dosage without consulting your doctor.

Store Syldo 8d Capsule 10 at room temperature below 30°C.
Keep it in a tightly closed container to protect it from light and moisture.
Always keep this medicine out of the reach of children.
Make sure to use the capsule before its expiry date.

Consume plenty of fluids daily. This can help manage benign prostatic hyperplasia (BPH) symptoms by encouraging regular urination, which helps keep the urinary system functioning properly.
Maintain a balanced diet with adequate fibre. This can benefit bowel movements, reduce pressure on the prostate gland, and potentially ease BPH symptoms.

Fact Box

Drug Category	5α-reductase Inhibitor, Alpha-blocker
Therapeutic Category	Urological Medication
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Benign Prostatic Hyperplasia

What is Syldo 8d Capsule 10 used for?

This capsule helps manage symptoms of an enlarged prostate in adult men, also known as benign prostatic hyperplasia.

How does Syldo 8d Capsule 10 work?

It contains two active ingredients that work together. Dutasteride shrinks the prostate over time, and silodosin relaxes muscles to improve urinary symptoms.

How should I take Syldo 8d Capsule 10?

Take one capsule orally, and remember not to chew, open, or crush the capsule. Consult your doctor before taking this medication.

Can anyone use Syldo 8d Capsule 10?

No, it is contraindicated in women, children, and patients with severe renal or hepatic impairment. Please consult your doctor for guidance.

Can Syldo 8d Capsule 10 interact with other medicines?

Yes, it can interact with potent CYP3A4 inhibitors and other medications, increasing the risk of side effects. It is a good idea to consult your doctor before taking this medicine.

What are the common side effects of Syldo 8d Capsule 10?

Common side effects include retrograde ejaculation, dizziness, diarrhoea, orthostatic hypotension, headache, nasopharyngitis, and nasal congestion. If these symptoms persist, consult your doctor.

How should I store my Syldo 8d Capsule 10?

Store this capsule at room temperature below 30°C in a tightly closed container away from light and moisture. Please consult your doctor for guidance.

Certified Content

Written by

Dr. Pauravi Abad

Medical Writer & Reviewer | 4 years

MBBS

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

T1/B NATIONAL PARKGULBAI TEKRA AHMEDABAD GJ 380015 IN

Country of origin: INDIA

References

U.S. National Library of Medicine. (2021). DUTASTERIDE- dutasteride capsule, liquid filled. DailyMed. Retrieved 1 April 2024, from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e537c60d-9ba2-4e7f-a405-2b915dcd7ead
U.S. National Library of Medicine. (2021). Silodosin: MedlinePlus Drug Information. MedlinePlus. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a609002.html
U.S. Food and Drug Administration. (2002). AVODART (dutasteride) Label. FDA. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21-319s1lbl.pdf
Silodosin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06207
U.S. Food and Drug Administration. (2020). RAPAFLO (silodosin) Label. FDA. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022206s016lbl.pdf

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