Syncapone 10025200 Mg Tablet 10

Syncapone 100 Tablet 10

Sun Pharma Laboratories Ltd.

Strip of 10 Units

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Composition

Carbidopa (25 Mg) + Entacapone (200 Mg) + Levodopa (100 Mg)

Syncapone 100 Tablet is used to manage the symptoms of Parkinson's disease. It is a combination medicine classified under anti-parkinsonian medications.

In addition to its primary use, this medicine also helps in managing the symptoms of parkinsonism, which includes mobility problems such as stiffness, slow movements, and impaired balance and coordination. These symptoms are a result of dopamine deficiency in certain areas of the brain.

This medicine should be taken orally as directed by your doctor. Before starting this medicine, it's important to inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects while on this medicine, notify your doctor immediately. Continue taking the tablet for the duration prescribed by your doctor for optimal results.

Syncapone 100 Tablet is used for managing the following conditions:

Parkinson's disease: a progressive neurological disorder characterised by movement difficulties.
Parkinsonism symptoms: including tremors, stiffness, slow movement, and impaired balance and coordination.

Directions for Use of Syncapone 100 Tablet 10

To use Syncapone 100 Tablet correctly, follow these instructions:

Swallow the tablet whole with a glass of water.
Do not chew or crush the tablet.
Stick to the dose advised by your doctor.
Avoid abruptly stopping this medicine without consulting your doctor.

Syncapone 100 Tablet is taken orally.

Syncapone 100 Tablet may have the following side effects:

Dyskinesia: This refers to uncontrolled, involuntary movements of your body.
Nausea
Diarrhoea
Urine discolouration: This is harmless and is due to the medication.
Dizziness
Dry mouth
Constipation
Fatigue
Hallucinations: These are visions or sounds that are not real and can be a result of this medicine.
Confusion

Managing the Side Effects:

Most side effects are temporary and generally harmless, which are resolved by discontinuing the use of Syncapone 100 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general suggestions for managing common side effects:

Nausea: Try taking Syncapone 100 Tablet with food or milk to handle this discomfort.
Diarrhoea: Consider taking this medicine with plenty of water to stay hydrated.

Syncapone 100 Tablet consists of three active ingredients:

Carbidopa (25 mg): This component doesn't cross the blood-brain barrier but inhibits the peripheral metabolism of levodopa. This allows more levodopa to enter your brain unchanged and allows for lower doses of levodopa to be used, reducing side effects such as nausea.
Entacapone (200 mg): As a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), entacapone reduces the breakdown of levodopa by inhibiting COMT. This extends its plasma half-life and increases its bioavailability, resulting in more sustained plasma levodopa levels.
Levodopa (100 mg): This amino acid precursor of dopamine crosses the blood-brain barrier and is converted into dopamine by dopa decarboxylase, an enzyme in your brain. By doing so, it replenishes deficient dopamine levels in your brain, improving parkinsonian symptoms.

Pregnancy

Caution is advised while taking Syncapone 100 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

The effects of Syncapone 100 Tablet on breastfeeding mothers are yet to be fully understood. It's wise to consult your doctor before using this medicine while lactating.

Alcohol

There's limited information on the interaction of Syncapone 100 Tablet with alcohol. However, caution is advised if you consume alcohol. Consult your doctor for more specific advice.

Liver

If you have any liver health issues, especially severe liver impairment, it's important to use Syncapone 100 Tablet carefully. Discuss your liver health with your doctor before starting the medication.

Kidney

For those with kidney health problems, caution is advised when taking Syncapone 100 Tablet. Consultation with your doctor is recommended beforehand.

Using Machines & Driving

Syncapone 100 Tablet can cause drowsiness or sudden sleep onset. Be cautious about operating hazardous machinery or driving until you know how the medicine affects you.

Allergy

Syncapone 100 Tablet should not be used if you have known allergies to any of its ingredients. If you're uncertain, discuss your allergies with your doctor.

Children

Syncapone 100 Tablet is meant for adult use. It's advisable not to give this medicine to children unless specifically recommended by a doctor.

Older Patients

Older patients may be more susceptible to side effects of Syncapone 100 Tablet and may have pre-existing liver or kidney issues. Your doctor will guide you based on your health status if you are above 70 years of age.

Drug-Drug Interactions

Syncapone 100 Tablet interacts with the following medicines:

MAO inhibitors: Medicines like phenelzine or tranylcypromine could cause a hypertensive crisis when combined with Syncapone 100 Tablet. Avoid this combination.
Antipsychotics: Medicines such as haloperidol or risperidone may reduce the effectiveness of levodopa present in Syncapone 100 Tablet. Use these together with caution.
Methyldopa: This medicine, when used with Syncapone 100 Tablet, can enhance the hypotensive effect. Avoid this combination.
Iron salts: If taken with Syncapone 100 Tablet, iron salts may reduce the bioavailability of levodopa. Separate administration by 2 to 3 hours.
Metoclopramide: This medicine can potentially decrease the bioavailability of levodopa in Syncapone 100 Tablet. Avoid this combination.

Drug-Food Interactions

There are no specific food items that have been reported to interact with Syncapone 100 Tablet.

Drug-Disease Interactions

Syncapone 100 Tablet interacts with the following diseases:

Severe hepatic impairment: If you have severe liver disease, Syncapone 100 Tablet could worsen your condition. You should use it with caution.
Narrow-angle glaucoma: There's a potential risk that Syncapone 100 Tablet might exacerbate narrow-angle glaucoma symptoms. Be cautious if you have this condition.
History of melanoma or suspicious skin lesions: If you have a history of melanoma or suspicious skin lesions, use Syncapone 100 Tablet cautiously, as it could potentially aggravate these conditions.

Daily Dose

It's vital to take your daily dose of Syncapone 100 Tablet as prescribed by your doctor. The dosage could vary based on factors such as how severe your condition is and how you respond to the medicine. Always stick to the dosage set by your doctor. Don't alter it without consulting your doctor first.

Over Dose

Overdosing on Syncapone 100 Tablet could cause symptoms like dizziness, dry mouth, and confusion. If you accidentally take more of this medicine than prescribed, inform your doctor.

Missed Dose

If you forget to take a dose of Syncapone 100 Tablet, take it as soon as you remember. If it's nearly time for the next dose, skip the forgotten one and get back to your regular schedule. Do not double the dose. Always consult your doctor if you're unsure about what to do after missing a dose.

Store Syncapone 100 Tablet in a cool, dry place where temperatures stay between 15-30°C.
Keep it away from direct light and moisture.
Always keep this medicine out of reach of children.
Make sure you use the medicine before its expiry date.

Regular physical activity can help manage the symptoms of Parkinson's disease. Gentle exercises like yoga or tai chi can improve your balance and flexibility.
A balanced diet is crucial. Include plenty of fruits, vegetables, and whole grains in your meals. These foods are rich in antioxidants which may help protect brain cells. Consult your doctor for specific dietary advice catered to you.

Fact Box

Drug Category	Dopamine Precursor and Enzyme Inhibitors
Therapeutic Category	Anti-Parkinsonian
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Parkinson's Disease, Parkinsonism Symptoms

What is Syncapone 100 Tablet used for?

Syncapone 100 Tablet is used to manage the symptoms of Parkinson's disease, a neurodegenerative disorder that affects movement.

How does Syncapone 100 Tablet work?

The medicine contains levodopa which replenishes deficient dopamine levels in the brain, while carbidopa and entacapone help more levodopa reach the brain.

Can I take Syncapone 100 Tablet with food?

Yes, Syncapone 100 Tablet can be taken with or without food. The tablets should be swallowed whole without chewing or crushing.

What are the common side effects of Syncapone 100 Tablet?

Common side effects include involuntary movements, nausea, diarrhoea, urine discolouration, dizziness, dry mouth, constipation, fatigue, hallucinations and confusion.

What precautions should I take while using Syncapone 100 Tablet?

Use it with caution if you have severe liver impairment, narrow-angle glaucoma or a history of melanoma and avoid it if allergic to any ingredient.

Can Syncapone 100 Tablet interact with other medicines?

Yes, it may interact with MAO inhibitors, antipsychotics, methyldopa and certain others. Always inform your doctor about all medicines you're taking.

How should I store Syncapone 100 Tablet?

Store the tablets at room temperature (15-30°C), away from light and moisture to maintain their effectiveness.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Osama Ahmed

Dental/Medical Writer, Editor, Reviewer | 2 years

Bachelor of Dental Surgery

Check out Editorial Policy

Manufacturer details

SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

References

U.S. National Library of Medicine. (n.d.). Carbidopa, Levodopa and Entacapone. DailyMed. Retrieved 1 April 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=97e7696c-5220-e5c3-9429-7fad5eda33fe
U.S. National Library of Medicine. (n.d.). Carbidopa and Levodopa. MedlinePlus. Retrieved 1 April 2024, from
https://medlineplus.gov/druginfo/meds/a601068.html
U.S. National Library of Medicine. (n.d.). Entacapone. MedlinePlus. Retrieved 1 April 2024, from
https://medlineplus.gov/druginfo/meds/a601236.html
U.S. Food and Drug Administration. (2008). Stalevo (Carbidopa, Levodopa and Entacapone) Label. FDA. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021485s017lbl.pdf
Muranova, A., & Shanina, E. (2024). Levodopa/carbidopa/entacapone combination therapy. In StatPearls. StatPearls Publishing. Retrieved 1 April 2024, from
https://www.ncbi.nlm.nih.gov/books/NBK599508/

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