Syndopa Cr 250 Mg Tablet 10

Syndopa Cr Tablet 10

Sun Pharma Laboratories Ltd.

Strip of 10 Units

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Composition

Carbidopa (50 Mg) + Levodopa (200 Mg)

Syndopa CR Tablet is primarily used for managing the signs and symptoms of Parkinson's disease. This medicine is a combination product and falls within the category of antiparkinsonian medicines.

In addition to its main use, this tablet also helps in managing post-encephalitic parkinsonism and symptomatic parkinsonism, which can be caused by injuries to the nervous system due to carbon monoxide or manganese intoxication.

It's important for you to take this medicine as per your doctor's instructions. Before starting on this medicine, let your doctor know about any existing health conditions or ongoing medications you might have. If you notice any side effects while on this medication, report them to your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

Managing the signs and symptoms of idiopathic Parkinson's disease
Addressing symptoms of post-encephalitic parkinsonism
Alleviating symptomatic parkinsonism that may follow injury to the nervous system by carbon monoxide intoxication
Reducing symptomatic parkinsonism resulting from manganese intoxication

Directions for Use of Syndopa Cr Tablet 10

Swallow the tablet whole with water.
Refrain from crushing or chewing the tablet.
Aim to take this medicine at the same time each day to maintain a consistent level in your body.
You can take this medicine with or without food. If you feel nauseous, taking it with food may help.
Remember not to consume high-protein meals or iron supplements around the same time as this medicine, as they might interfere with its absorption.
Always consult your doctor before altering the dosage or stopping the medicine

Syndopa CR Tablet is taken orally.

Dyskinesias: This refers to abnormal, uncontrolled movements that may occur.
Nausea
Dizziness
Headache
Dry Mouth
Dream abnormalities: This could mean experiencing unusual or vivid dreams.
Dystonia: This is a condition of sustained muscle contractions, causing twisting and repetitive movements.
Somnolence: This is a state of near-sleep or strong desire for sleep.

Managing the Side Effects:

Nausea: Try taking Syndopa CR Tablet with food to help alleviate this.
Dizziness: Consider taking your medicine at night if it causes you to feel dizzy during the day.

Syndopa CR Tablet consists of two components:

Carbidopa (50 mg): Carbidopa does not cross into your brain. It works by blocking the conversion of levodopa into dopamine in other parts of your body. This reduces side effects like nausea and vomiting and allows a greater amount of levodopa to enter your brain.
Levodopa (200 mg): Unlike dopamine, levodopa can cross into your brain. Once it is in there, it gets converted into dopamine by an enzyme called DOPA decarboxylase. This increase in brain dopamine levels helps manage symptoms of Parkinson's disease.

Pregnancy

Caution is advised while taking Syndopa CR Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, it's important to discuss with your doctor before starting Syndopa CR Tablet.

Alcohol

It's advisable to limit alcohol consumption while taking Syndopa CR Tablet. High alcohol intake might interfere with the medicine's efficacy.

Liver

If you have a history of liver problems, it's recommended to talk to your doctor before starting Syndopa CR Tablet. This medicine may affect liver function.

Kidney

If you've had kidney health issues in the past, caution is advised while taking Syndopa CR Tablet. Consult your doctor for advice tailored to your health status.

Using Machines & Driving

Syndopa CR Tablet may cause dizziness or somnolence. It's advisable not to drive or operate heavy machinery until you know how this medicine affects you.

Allergy

If you're allergic to any component of Syndopa CR Tablet, avoid using this medicine. Discuss with your doctor for alternative options.

Children

Syndopa CR Tablet is not typically recommended for children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should use Syndopa CR Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Dopamine D2 Receptor Antagonists: Medicines such as phenothiazines, butyrophenones, and risperidone may decrease the effectiveness of Levodopa in Syndopa CR Tablet.
Nonselective Monoamine Oxidase (MAO) Inhibitors: The use of selegiline, and tranylcypromine is contraindicated with Syndopa CR Tablet due to potential severe interactions.
Iron salts: These can reduce the amount of Levodopa available to your body when taken alongside Syndopa CR Tablet.

Drug-Food Interactions

Eating a high-protein diet could reduce the effectiveness of Syndopa CR Tablet. It's recommended to distribute your daily protein intake so that most of it is consumed in the evening meal.

Drug-Disease Interactions

Neuroleptic Malignant Syndrome (NMS) or Akinetic Crisis: Abrupt withdrawal or dose reduction of Syndopa CR Tablet could trigger these conditions.
Myocardial Infarction or Arrhythmias: Patients with a history of these heart conditions should exercise caution while taking this medication.
Narrow-Angle Glaucoma: This medicine should not be used by patients with this eye condition due to potential severe complications.
Skin Lesions or Melanoma: Regular monitoring for melanoma is advised for patients with suspicious undiagnosed skin lesions or a history of melanoma while taking this medication.

Daily Dose

The daily dose of Syndopa CR Tablet should be consumed as advised by your doctor. The dosage may vary based on individual responses and the severity of your condition. Always adhere to your doctor's instructions and avoid exceeding the recommended dosage.

Over Dose

If you accidentally consume more Syndopa CR Tablet than your prescribed dose, you may experience increased side effects such as nausea, dizziness, or abnormal involuntary movements. If these symptoms persist or worsen, consult your doctor.

Missed Dose

In case you forget to take Syndopa CR Tablet at the scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosing schedule. Never increase your dose without consulting your doctor.

Keep Syndopa CR Tablet in a dry place, away from light and moisture.
The optimal storage temperature is below 25°C.
Always ensure the medicine is out of reach of children.
Remember to use the medicine before its expiry date.

To help manage Parkinson's disease, try performing gentle exercises like yoga or Tai Chi. These might help improve your balance, flexibility, and muscle strength.
A balanced diet is crucial. However, large amounts of protein may affect how this medicine works. Try to consume most of your daily protein in the evening meal.

Fact Box

Drug Category	Dopamine Precursor
Therapeutic Category	Antiparkinsonian
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Parkinson's Disease, Post-Encephalitic Parkinsonism

How does Syndopa CR Tablet work?

Syndopa CR Tablet contains levodopa and carbidopa. Levodopa is converted to dopamine in the brain, helping manage symptoms of Parkinson's disease. Carbidopa reduces side effects by ensuring more levodopa reaches the brain.

When should I take Syndopa CR Tablet?

Take Syndopa CR Tablet exactly as prescribed by your doctor.

What precautions should I take while using this medication?

If you have a history of heart problems, glaucoma, skin lesions, or severe disease such as asthma or kidney disease, consult your doctor before starting Syndopa CR Tablet.

Are there any dietary restrictions while on this medication?

Avoid high-protein meals and iron supplements while taking Syndopa CR Tablet as they may interfere with levodopa absorption. Distribute protein intake throughout the day for better effectiveness.

Can I crush or chew the Syndopa CR Tablets?

No, the tablets should be swallowed whole without crushing or chewing to maintain the extended-release properties.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed one and continue with your regular schedule.

Will this medication cure my Parkinson's disease?

No, Syndopa CR Tablet does not cure Parkinson's disease but helps manage its symptoms effectively. Always consult your doctor before making any changes to your medication regimen.

Certified Content

Written by

Dr Vatsalya D Ghanekar

Medical Content Writer | 5 years

MD Ayurveda

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

References

NDA 17-555/S-069. (2000). SINEMET (CARBIDOPA-LEVODOPA) TABLETS. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/017555s069lbl.pdf
Riverside Pharmaceuticals. (1975). DHIVY (carbidopa and levodopa) tablets, for oral use. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214869s000lbl.pdf
AbbVie Inc. (2020). DUOPA [Prescribing information]. In DUOPA. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/203952s011lbl.pdf
Highlights of prescribing information. (2015). https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/203952s000lbl.pdf
DailyMed - CARBIDOPA AND LEVODOPA tablet, extended release. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=11587fa6-dc2c-44a5-85c6-85ec40c6b9b1

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