Tenvir Af Tablet 30

Cipla Ltd.

Bottle of 30 Units

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MRP ~~₹1464.7~~

₹1171.76

₹48.82/Units

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Composition

Tenofovir Alfenamide (25 Mg)

Tenvir-AF Tablet is primarily used to manage chronic hepatitis B virus (HBV) infection and human immunodeficiency virus type 1 (HIV-1) infection. This medication falls under the class of medicines known as nucleotide reverse transcriptase inhibitors (NtRTIs).

In addition to managing HBV and HIV-1 infections, this medicine also finds use in adults with compensated liver disease. It is used alongside other antiretroviral agents for managing HIV-1 infection in adults and children who weigh at least 25 kg.

Taking this medicine should always follow your doctor's instructions. It is crucial to inform your doctor about any pre-existing health conditions or current medications before starting on this medicine. If you experience any side effects while on this medicine, it's important to notify your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

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Tenvir-AF Tablet is used in the treatment of HIV (Human Immunodeficiency Virus) infection. It contains a combination of antiretroviral drugs that help reduce the viral load, prevent the progression of the disease, and improve the immune system's function. This tablet is often prescribed as part of combination therapy to manage HIV effectively.

Directions for Use of Tenvir Af Tablet 30

Here's how you should take Tenvir-AF Tablet:

Follow the dosage and timing instructions provided by your doctor precisely.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Tenvir-AF Tablet is taken orally.

Tenvir-AF Tablet may have the following common side effects:

Nausea
Headache
Fatigue
Diarrhoea
Abdominal pain
Cough

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Tenvir-AF Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some guidelines for managing common side effects:

Nausea: Follow the dietary recommendations provided by your doctor.
Diarrhoea: Drink plenty of healthy fluids to stay hydrated and follow the diet recommended by your doctor.

Tenvir-AF Tablet contains tenofovir alafenamide (25 mg) and its action on the body involves:

Inhibition of Replication: Once transformed into tenofovir diphosphate, this medicine works against both HBV and HIV-1 by inhibiting their replication process. It does this by competing with a natural substance in your body called deoxyadenosine 5'-triphosphate, which these viruses normally use to copy themselves.
Termination of DNA Chain Elongation: After being incorporated into viral DNA by specific enzymes of HBV and HIV-1 (known as reverse transcriptase enzymes), tenofovir diphosphate stops these viruses from making more copies of themselves by terminating the elongation of their DNA chains. This helps to control the number of virus particles in your body.

Pregnancy

If you are pregnant or planning a pregnancy, caution is advised while taking Tenvir-AF Tablet. Always consult your doctor to weigh potential benefits against potential risks.

Breastfeeding

You should consider the health benefits of breastfeeding and your need for this medication before deciding to continue with nursing.

Alcohol

There are no interactions between alcohol and Tenvir-AF Tablet. However, regular, moderate-to-heavy drinking might worsen some health conditions managed by this medicine, so it’s wise to consult your doctor.

Liver

Tenvir-AF Tablet can be used by those with mild liver issues but isn't recommended if you have severe liver disease. If you have any liver problems, discuss them with your doctor before starting Tenvir-AF Tablet.

Kidney

If you have any kidney problems, exercise caution before taking this medicine. It's best to consult your doctor first.

Using Machines & Driving

No specific precautions are needed when using machines or driving while taking Tenvir-AF Tablet. However, always monitor how the medicine affects you before undertaking such tasks.

Allergy

If you're allergic to any ingredients in Tenvir-AF Tablet, avoid using it. Always inform your doctor about any allergies before starting a new medication.

Children

Tenvir-AF Tablet has been found safe for children weighing at least 25 kg, when used in combination with other antiretroviral agents. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should use Tenvir-AF Tablet under medical supervision as they may be more susceptible to side effects and may also have liver and kidney issues. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Tenvir-AF Tablet interacts with the following medicines:

Antiviral Medications: Care is needed when taking medicines such as acyclovir, valacyclovir, cidofovir, ganciclovir, or valganciclovir alongside Tenvir-AF Tablet. This combination could increase levels of Tenofovir in your body, potentially leading to adverse reactions.
Aminoglycosides: Antibiotics such as gentamicin or tobramycin might increase the concentration of Tenofovir in your body when taken with Tenvir-AF Tablet, potentially leading to an increased risk of side effects.
NSAIDs: Regular use of NSAIDs like ibuprofen or naproxen alongside Tenvir-AF Tablet may increase the concentrations of Tenofovir in your body, leading to a higher likelihood of side effects.

Drug-Food Interactions

No specific food interactions have been identified for Tenvir-AF Tablet. Consequently, you can take this medicine with most foods unless your doctor advises otherwise.

Drug-Disease Interactions

Tenvir-AF Tablet interacts with the following diseases:

Renal Impairment: If you have kidney disease or poor kidney function, using this medicine could worsen your condition due to increased levels of Tenofovir in your body.
Hepatic Impairment: Caution is required if you have liver disease. Using Tenvir-AF Tablet could worsen your condition, particularly if you have serious liver disease (Child-Pugh Class B or C).

Daily Dose

The daily dose of Tenvir-AF Tablet should be taken exactly as your doctor advises. This may vary based on factors such as the severity of your condition and how well you respond to the medicine. Remember, it's crucial to follow the prescribed dosage without exceeding it unless your doctor tells you otherwise.

Over Dose

In case you unintentionally take more than the prescribed amount of Tenvir-AF Tablet, you might feel nauseous, have a headache, or experience fatigue. It's best to inform your doctor about the situation.

Missed Dose

If you forget to take your Tenvir-AF Tablet at the usual time, take it as soon as you remember. But if it's nearly time for your next dose, just skip the missed one and continue with your regular schedule. Don't increase your dosage without consulting your doctor.

Keep your Tenvir-AF Tablet in its original packaging.
Store it below 30°C, away from direct heat or sunlight.
Ensure the storage area is dry and free from moisture.
Always keep the Tablet out of reach and sight of children.
Use the Tablet before its expiry date.

To better manage chronic hepatitis B virus (HBV) infection, limit alcohol consumption as it could potentially worsen liver damage.
For individuals managing human immunodeficiency virus type 1 (HIV-1) infection, maintain a balanced diet rich in fruits, vegetables, lean proteins, and whole grains to support your immune system.

Fact Box

Drug Category	Nucleotide Reverse Transcriptase Inhibitors
Therapeutic Category	Antiviral
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Hepatitis B, HIV-1 Infection

What is Tenvir-AF Tablet used for?

Tenvir-AF Tablet is used to manage chronic hepatitis B virus (HBV) infection and human immunodeficiency virus type 1 (HIV-1) infection in adults.

How does Tenvir-AF Tablet work?

Tenvir-AF Tablet contains tenofovir alafenamide, which inhibits the replication of HBV and HIV-1, thereby helping to control these viral infections.

Can Tenvir-AF Tablet be taken with food?

Yes, Tenvir-AF Tablet should be taken orally once daily with food as it helps in the absorption of the medicine.

What are the common side effects of Tenvir-AF Tablet?

Common side effects include nausea, headache, tiredness, diarrhoea, stomach pain, and coughing. Consult your doctor if these persist or worsen.

Can Tenvir-AF Tablet interact with other medicines?

Yes, certain medicines like acyclovir and aminoglycosides may interact with Tenvir-AF Tablet. Always inform your doctor about all the medicines you're taking.

Is it safe to use Tenvir-AF Tablet during pregnancy or breastfeeding?

The safety of Tenvir-AF Tablet during pregnancy and breastfeeding is not fully established. It should be used only if the benefits outweigh the potential risks.

Can individuals with kidney or liver impairment take Tenvir-AF Tablet?

Tenvir-AF Tablet can be taken by patients with mild liver impairment or kidney problems, but not recommended for severe cases. Always consult your doctor.

Last Updated On 28 Jan. 2025 | 3:39AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 9 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: INDIA

References

Gilead Sciences, Inc. (2012). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021356s042,022577s002lbl.pdf
Gilead Sciences, Inc. (2019). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.gilead.com/-/media/files/pdfs/medicines/hiv/viread/viread_pi.pdf
Teva Canada Limited. (2017). PRODUCT MONOGRAPH. https://pdf.hres.ca/dpd_pm/00040336.PDF
Tenofovir disoproxil fumarate FDA label | NIH. (n.d.). https://clinicalinfo.hiv.gov/en/drugs/tenofovir-disoproxil-fumarate/fda-label
Tenofovir disoproxil: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00300

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