Topp 40 Tablet 10

Systopic Laboratories Ltd-mem

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Composition

Pantoprazole (40 Mg)

Topp-40 Tablet is primarily used to manage gastroesophageal reflux disease (GERD), a condition where stomach acid flows back into the oesophagus causing heartburn and irritation. This medication falls under the group known as proton pump inhibitors (PPIs).

In addition to managing GERD, this medicine is also employed for maintaining the healing of erosive oesophagitis, an inflammation that damages your lower oesophagus. It is also used to manage pathological hypersecretory conditions like Zollinger-Ellison syndrome, where the stomach produces too much acid.

You should take this medicine as directed by your doctor. It's important to inform your doctor about any existing medical conditions or other medications you are taking before starting this medicine. If you experience any side effects while on this medication, notify your doctor immediately. Please ensure that you continue taking the medicine for as long as prescribed by your doctor for optimal results.

Topp-40 Tablet is used for the following:

Managing gastroesophageal reflux disease (GERD) in adults, which is a condition causing acid from your stomach to flow back into your food pipe, leading to heartburn
Healing erosive oesophagitis, which is a type of injury to the food pipe caused by stomach acid
Maintaining the healed state of erosive oesophagitis and preventing its recurrence
Controlling pathological hypersecretory conditions like Zollinger-Ellison syndrome, where your stomach produces too much acid
Providing short-term relief from erosive esophagitis associated with GERD in children aged 5 years and above.

Here's how you should take Topp-40 Tablet:

Follow the dosage and timing instructions provided by your doctor precisely.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Topp-40 Tablet is taken orally.

Topp-40 Tablet might have the following common side effects:

Headache
Diarrhoea
Nausea
Abdominal pain
Vomiting
Flatulence: This is also known as gas, which might make you feel bloated.
Dizziness
Arthralgia: This refers to joint pain, which can occur in any part of your body where two or more bones meet.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Topp-40 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of guidelines for managing common side effects:

Abdominal pain: Follow the dietary recommendations provided by your doctor precisely.
Flatulence: Completely avoid junk food for a few days.

Topp-40 Tablet contains pantoprazole (40 mg) which works in the body through the following mechanisms:

Inhibits H+/K+-ATPase Enzyme: Pantoprazole works by specifically inhibiting a system known as H+/K+-ATPase enzyme at the secretory surface of your stomach lining cells, called parietal cells.
Reduces Gastric Acidity: By inhibiting this enzyme system, pantoprazole effectively reduces gastric acidity. This helps in providing relief from acid-related symptoms and allows the healing of lesions in the oesophagus and stomach.

Pregnancy

If you are pregnant, it is best to be cautious while taking Topp-40 Tablet. The potential benefits should always be weighed against the possible risks to your unborn baby. Consult your doctor before starting this medicine.

Breastfeeding

Pantoprazole, the active ingredient in Topp-40 Tablet, can pass into breast milk. Assess the developmental and health benefits of breastfeeding alongside your need for this medicine. Consult your doctor for advice.

Alcohol

Caution is advised while consuming alcohol during this medication. Please consult your doctor for more information.

Liver

Topp-40 Tablet is metabolised extensively in the liver. If you have liver problems, it's advised to discuss them with your doctor before starting this medicine. It could affect liver function and require monitoring.

Kidney

Caution is advised if you have a history of kidney problems. It's recommended to consult your doctor before starting Topp-40 Tablet.

Using Machines & Driving

Topp-40 Tablet might cause side effects like dizziness which may affect your ability to drive or operate machinery. You should know how you react to this medicine before driving or using any tools or machines.

Allergy

If you are allergic to any component of Topp-40 Tablet or similar medicines, avoid its use. Hypersensitivity reactions may occur, which can be severe.

Children

Topp-40 Tablet can be given to children aged 5 years and above for short-term management of erosive oesophagitis associated with GERD. Always consult a doctor before giving this medicine to a child.

Older Patients

Older patients should take Topp-40 Tablet under medical supervision as they may be more susceptible to its side effects. If patients are above 70 years of age, caution is particularly advised. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Topp-40 Tablet interacts with the following medicines:

Blood thinners: Medicines such as warfarin may interact with Topp-40 Tablet, potentially increasing the risk of bleeding.
Platelet aggregation inhibitors: Medicines like clopidogrel can have their effectiveness reduced when taken alongside Topp-40 Tablet.
Anticancer medicines: When combined with Topp-40 Tablet, methotrexate levels may increase in the body, leading to enhanced side effects.

Drug-Food Interactions

Topp-40 Tablet doesn't have any specific interactions with food. However, it's always a good idea to consume a balanced diet while on medication.

Drug-Disease Interactions

Topp-40 Tablet interacts with the following diseases:

Liver disease: If you have liver issues, your body's ability to metabolise and eliminate Topp-40 Tablet could be affected.
Vitamin B12 Deficiency: Long-term use of Topp-40 Tablet could lead to a decrease in Vitamin B12 absorption.
Bone Fractures: There's an increased risk of bone fractures associated with prolonged use of proton pump inhibitors like Topp-40 Tablet.
Lupus Erythematosus: Rare instances of cutaneous and systemic lupus erythematosus have been reported in patients taking PPIs, including those using Topp-40 Tablet.

Daily Dose

It's important to take your daily dose of Topp-40 Tablet as instructed by your doctor. This dosage may vary depending on factors such as the severity of your condition and how you respond to this medicine. Always follow your doctor's prescribed dosage and avoid exceeding it without first consulting your doctor.

Over Dose

If you accidentally take more Topp-40 Tablet than prescribed, you might experience symptoms like confusion, blurred vision, or feelings of nausea. It's important not to panic but do inform your doctor about the situation.

Missed Dose

If you realise that you've missed a dose of Topp-40 Tablet, take it as soon as you remember. However, if the time for your next dose is near, skip the missed dose and continue with your usual dosage schedule. Never increase your dosage without consulting your doctor.

Store Topp-40 Tablet at room temperature, ideally below 30°C.
Keep away from direct light and moisture.
Ensure the medicine is out of reach of children.
Remember to use this product before its expiry date.

To help manage symptoms of Gastroesophageal reflux disease (GERD), avoid foods that trigger heartburn, such as spicy or fatty foods, chocolate, and caffeine.
Regular, gentle exercise can support digestive health. However, avoid intense workouts soon after meals as they can worsen GERD symptoms.

Fact Box

Drug Category	Proton Pump Inhibitor
Therapeutic Category	Antacid
Available Dosage Types	Tablet
Habit Forming	No
Ailment	GERD, Erosive Esophagitis, ZE Syndrome

What is Topp-40 Tablet used for?

Topp-40 Tablet is prescribed to manage acid-related disorders of the stomach and oesophagus, including gastroesophageal reflux disease and Zollinger-Ellison syndrome.

How does the Topp-40 Tablet work?

Topp-40 Tablet contains pantoprazole, which reduces stomach acidity by specifically blocking the final step of acid production in the stomach.

Can I take Topp-40 Tablet with antacids?

Yes, you can. Antacids do not affect the absorption of pantoprazole, the active component in Topp-40 Tablet.

What are possible side effects of Topp-40 Tablet?

Common side effects may include headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and joint pain.

Who shouldn't take Topp-40 Tablet?

Topp-40 Tablet should not be taken by people who are allergic to pantoprazole or any other component of this medicine.

Does Topp-40 Tablet interact with other medicines?

Yes, it may interact with medicines like warfarin, clopidogrel, or methotrexate. Always consult your doctor before starting any new medication.

Can I take Topp-40 Tablet during pregnancy or while breastfeeding?

You should use Topp-40 Tablet during pregnancy or while breastfeeding only if your doctor believes the benefits outweigh the potential risks.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

References

Pfizer Inc. (2000). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020987s045lbl.pdf
Pantoprazole: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00213
DailyMed - PANTOPRAZOLE SODIUM DELAYED RELEASE- pantoprazole sodium tablet. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e4edc4d-fa80-4afc-9864-59009764601f
Pantoprazole: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a601246.html

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