Valvorex 750 Er Tablet 10

Leeford Healthcare

Strip of 10 Units

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MRP ~~₹90~~

₹44.91

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Store Below 30^o C

Composition

Divalproex (750 Mg)

Strength:

500 MG 250 MG 750 MG

Valvorex 750 Er Tablet 10 is primarily used to control and prevent seizures. This medication is part of a group of medicines known as anticonvulsants and mood stabilisers.

In addition to managing bipolar disorder, this tablet also plays a crucial role in controlling and preventing complex partial seizures, occurring either alone or in combination with other types of epileptic seizures. Moreover, it is also used for the prophylaxis of migraine headaches, reducing the frequency and intensity of these attacks.

Before starting this medicine, you must consult your doctor who will guide you on the correct dosage and frequency. Make sure you inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects while taking this medication, notify your doctor immediately. Continue taking this medicine for the duration prescribed by your doctor for optimal results.

Valvorex 750 Er Tablet 10 is used for managing the following health conditions:

Episodes of acute mania or mixed states in bipolar disorder
Complex partial seizures, whether occurring alone or with other seizure types
Prophylaxis or prevention of migraine headaches

Each of these conditions can significantly impact your daily life, and this medication helps to control their symptoms, enhancing the quality of your life and comfort.

Directions for Use of Valvorex 750 Er Tablet 10

Here's how you should take Valvorex 750 Er Tablet 10:

Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet, as this can affect its effectiveness.
This medicine can be taken with or without food, according to your doctor's consultation.
Do not exceed the recommended dose without consulting your doctor.

Remember, it's important to continue taking this medicine for as long as your doctor has prescribed it. If you're unsure about anything or have questions, don't hesitate to consult your doctor.

Valvorex 750 Er Tablet 10 is taken orally.

Side Effects of Valvorex 750 Er Tablet 10

Valvorex 750 Er Tablet 10 might have the following common side effects:

Nausea
Vomiting
Indigestion
Abdominal pain
Dizziness
Drowsiness: You may feel sleepy or less alert than usual.
Tremor: You may notice a slight shaking in your hands or other body parts.
Weakness
Rash
Hair loss

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Valvorex 750 Er Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Indigestion: If you have discomfort in your stomach, consider taking this medicine with meals to lessen this effect.
Drowsiness: If you feel sleepy after taking Valvorex 750 Er Tablet 10, you may want to take it at bedtime.

Valvorex 750 Er Tablet 10 contains divalproex (750 mg), which has several actions on the body:

Increased Brain Concentrations of GABA: The therapeutic effects of divalproex are believed to be associated with increased concentrations of Gamma-Aminobutyric acid (GABA) in the brain. GABA is a chemical that sends messages between the brain and the nervous system, and its increased levels can help control seizures.
Effects on GABA and Glutamate: Divalproex may affect both GABA and glutamate, two significant neurotransmitters in the brain. These effects could contribute to its ability to manage manic episodes in bipolar disorder.
Influence on Sodium Channels: It's suggested that divalproex's therapeutic activity might also involve its effects on voltage-sensitive sodium channels in our brain cells.

Pregnancy

Valvorex 750 Er Tablet 10 is contraindicated during pregnancy due to a high risk of birth defects. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Women who are breastfeeding should consult their doctor before using Valvorex 750 Er Tablet 10.

Alcohol

Caution is advised while consuming alcohol during the period you are taking this medicine. It's best to discuss it with your doctor.

Liver

If you have liver problems, caution is advised when taking Valvorex 750 Er Tablet 10. This medicine could affect liver function, particularly if you have hepatic disease or significant hepatic dysfunction.

Kidney

If you have any kidney problems, it is advised to exercise caution before using Valvorex 750 Er Tablet 10. It is recommended to consult your doctor beforehand.

Using Machines & Driving

As Valvorex 750 Er Tablet 10 may cause dizziness and drowsiness, caution is recommended while driving or operating heavy machinery.

Allergy

Valvorex 750 Er Tablet 10 is contraindicated in patients with known hypersensitivity. If you have a history of allergies, consult your doctor before starting this medication.

Children

Valvorex 750 Er Tablet 10 is intended for adult use. Always consult your doctor before giving any medication to a child.

Older Patients

Older patients should take Valvorex 750 Er Tablet 10 under medical supervision, as they may be more susceptible to its side effects. Caution is advised if patients are over 70 years of age. Your doctor will guide you based on your health status.

Interactions of Valvorex 750 Er Tablet 10

Drug-Drug Interactions

Valvorex 750 Er Tablet 10 interacts with the following medicines:

Anti-epileptic Medicines: When taken with other antiepileptic medicines like carbamazepine and phenytoin, divalproex can alter their levels and increase the risk of side effects or reduce seizure control.
Anti-depressants: Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and sertraline can increase the concentration of divalproex, leading to enhanced side effects.
Anti-coagulants: Medications like warfarin may have an increased risk of bleeding when taken with divalproex due to its potential to alter clotting times.
CNS Depressants: Combining divalproex with benzodiazepines or opioids may enhance sedative effects, leading to increased drowsiness and impaired motor function.

Drug-Food Interactions

Consuming high-fat meals, like oils, butter, fish, etc., before taking this medication may slow down its absorption and reduce its effectiveness.

Drug-Disease Interactions

Valvorex 750 Er Tablet 10 interacts with the following diseases:

Liver disease: If you have a liver disease or significant liver dysfunction, using this medicine could potentially worsen your condition.
Urea cycle disorders: This medication should not be used if you have known urea cycle disorders, as it can increase ammonia levels in your body.
Bipolar disorder: The medicine can increase the risk of suicidal thoughts or behaviour. Monitor for any unusual changes in mood or behaviour.

Daily Dose

You should take your daily dose of Valvorex 750 Er Tablet 10 as prescribed by your doctor. The dosage may vary based on factors like condition severity and response to the medication. Remember to follow the prescribed dosage and avoid exceeding it without a doctor's consultation.

Over Dose

Overdosing on Valvorex 750 Er Tablet 10 can lead to common side effects like drowsiness, dizziness, or an upset stomach. If you suspect an overdose, inform your doctor right away.

Missed Dose

If you forget to take Valvorex 750 Er Tablet 10, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never increase your dosage without consulting your doctor.

Store Valvorex 750 Er Tablet 10 at a temperature below 30°C.
Protect it from light and moisture to maintain its effectiveness.
Always keep the medicine out of reach of children for their safety.
Make sure you use this medicine before its expiration date for optimal results.

If you're taking Valvorex 750 Er Tablet 10 for bipolar disorder, try incorporating stress management techniques like yoga or meditation into your routine. These can help manage mood swings and improve overall mental well-being.
For those using this medicine to manage seizures, a balanced diet rich in fruits, vegetables, and whole grains can support overall brain health. Limit your intake of processed foods, as certain additives may potentially trigger seizures in some individuals.

Fact Box

Drug Category	Anticonvulsant, Mood-Stabilizer
Therapeutic Category	Neuro-Psychiatry
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Bipolar Disorder, Complex Partial Seizures, Migraine Prophylaxis

What is Valvorex 750 Er Tablet 10 used for?

This medicine is used to manage acute manic episodes linked to bipolar disorder, complex partial seizures, and migraine headaches.

How does Valvorex 750 Er Tablet 10 work?

This medicine works by increasing the concentration of a brain chemical called gamma-aminobutyric acid (GABA) which helps regulate mood and seizures.

Can I take this medicine with food?

Yes, you can take Valvorex 750 Er Tablet 10 with or without food as per your doctor's advice.

Are there any side effects of Valvorex 750 Er Tablet 10?

Yes, common side effects include nausea, dizziness, vision changes, rash, weight gain, and mood changes.

Is Valvorex 750 Er Tablet 10 safe during pregnancy?

No, it has a high risk of causing birth defects. Women of childbearing potential must use effective contraception while taking this tablet.

What precautions should I take while using this medicine?

Monitor for signs of liver damage, pancreatitis, and depression. Regular blood tests are advised to check liver function during treatment.

Can Valvorex 750 Er Tablet 10 interact with other medicines?

Yes, it can interact with several medicines like phenytoin, aspirin, and diazepam which might alter its efficacy or increase side effects.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Leo House, Shaheed Bhagat Singh Nagar, Dugri Dhandra Road, Near Joseph School Ludhiana PB 141002 IN

Country of origin: INDIA

References

FDA. (2011). Depakote (divalproex sodium) Tablets for Oral use (pp. 1–57). https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018723s037lbl.pdf
Depakote® (divalproex sodium): Bipolar mania & epilepsy. (n.d.). Depakote® (divalproex sodium): bipolar mania & epilepsy. https://www.depakote.com/prescribing-information
DailyMed - DIVALPROEX SODIUM capsule, coated pellets. (n.d.). https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=71e803ef-f684-dc73-9612-9c05cb091405&version=7
Divalproex sodium | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/salts/DBSALT000185
Bond, D. J., Lam, R. W., & Yatham, L. N. (2010). Divalproex sodium versus placebo in the treatment of acute bipolar depression: A systematic review and meta-analysis. Journal of Affective Disorders, 124(3), 228–234. https://doi.org/10.1016/j.jad.2009.11.008

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