Zerograin 10 Mg Tablet 10

Zerograin 10 Tablet 10

Mankind Pharmaceuticals Ltd.

Strip of 10 Units

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Composition

Flunarizine (10 Mg)

Zerograin 10 Tablet is primarily used for the prevention of migraine headaches, a neurological condition that can cause severe pain, nausea, and sensitivity to light and sound. This medicine belongs to a class of medications known as calcium channel blockers.

Apart from managing migraines, this tablet is also beneficial in reducing symptoms of dizziness and vertigo. These conditions involve a sense of spinning or loss of balance which can be quite disturbing in daily life.

Before starting this medicine, it's important to consult your doctor for the right dosage and frequency. Make sure you inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects while taking this medicine, notify your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

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Zerograin 10 Tablet is used for the following:

Prevention of recurrent migraine headaches
Management of disabling neurological symptoms accompanying migraines such as aura, one-sided weakness, dizziness, and vertigo.

Directions for Use of Zerograin 10 Tablet 10

Here's how you should take Zerograin 10 Tablet:

Swallow the tablet whole with a glass of water.
Avoid chewing or crushing the tablet.
Aim to take the tablet at the same time each day, preferably at night.
If you forget a dose, take it as soon as you remember unless it's nearly time for your next dose. In that case, skip the missed dose. Do not double up on doses.
Always consult your doctor if you are unsure about anything related to this medicine's use.

Zerograin 10 Tablet is taken orally.

You might experience some side effects when taking Zerograin 10 Tablet. The common ones include:

Drowsiness
Weight gain due to increased appetite
Depression
Dry mouth
Nausea
Anxiety
Muscle aches

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Zerograin 10 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some tips to manage common side effects:

Drowsiness: You may find it helpful to take Zerograin 10 Tablet at bedtime to lessen the drowsiness during daytime activities.
Nausea: Try taking your medicine after meals to minimize this effect.

Zerograin 10 Tablet contains flunarizine (10 mg), which acts on your body through the following mechanisms:

Calcium Channel Blocker: Flunarizine acts as a selective calcium channel blocker. It blocks the entry of calcium into neurons, thereby reducing their excitability. By doing so, it helps prevent abnormal dilation of blood vessels in the brain that can trigger migraines.
Antihistamine Activity: In addition to blocking calcium channels, flunarizine also binds to calmodulin and exhibits antihistamine activity at the H1 receptor. This helps in preventing migraines and managing vertigo by reducing inflammation and promoting normal blood flow in the brain.

Pregnancy

Caution is advised while taking Zerograin 10 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, Zerograin 10 Tablet should be used with caution. It's recommended to discuss this with your doctor before starting this medicine.

Alcohol

Avoid alcohol consumption while taking Zerograin 10 Tablet as it can increase drowsiness and impair alertness.

Liver

Caution is advised when using Zerograin 10 Tablet in case of mild to moderate liver impairment. Discuss your liver health with your doctor before starting this medicine as it may affect liver function.

Kidney

If you have a history of kidney problems, exercise caution before using Zerograin 10 Tablet. Always consult your doctor before starting this medication.

Using Machines & Driving

Zerograin 10 Tablet can cause drowsiness and impair alertness. Refrain from driving or operating heavy machinery until you know how the medicine affects you.

Allergy

Don't take Zerograin 10 Tablet if you're allergic to flunarizine or any of the other ingredients in the tablet. Discuss any known allergies with your doctor prior to starting this medication.

Children

Zerograin 10 Tablet is generally not recommended for children under 12 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Zerograin 10 Tablet under medical supervision as they could be more susceptible to its side effects. Caution is advised if patients are above 70 years of age due to potential liver and kidney issues. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Zerograin 10 Tablet Interacts with the Following Medicines:

Sedatives and Sleeping Pills: When combined with sedatives such as lorazepam or sleeping pills like zolpidem, the medication can cause excessive drowsiness.
Anti-Anxiety Medicines: This medicine may interact with anti-anxiety medications like diazepam or alprazolam, leading to an increase in drowsiness and dizziness.
Antipsychotics and Tranquilisers: Taking this medicine with antipsychotics like risperidone, and tranquilisers such as haloperidol can result in low blood pressure, increased drowsiness and dizziness.
Anticonvulsants: When used with anticonvulsants like carbamazepine or phenytoin for seizures, the sedative effect of both medicines might be increased.

Drug-Food Interactions

Consuming grapefruit juice while taking this medication can potentially increase the levels of flunarizine in your body, enhancing its effects and side effects.

Drug-Disease Interactions

Zerograin 10 Tablet Interacts with the Following Diseases:

Depression: People who have depression should use this medicine cautiously as it may exacerbate their condition.
Parkinson's Disease: This medicine is not recommended for those who have Parkinson's disease or a family history of Parkinson's because it could worsen their symptoms.
Severe Liver Impairment: Patients with severe liver issues should avoid this medication as it can further deteriorate their condition.

Daily Dose

The daily dose of Zerograin 10 Tablet should be taken as your doctor advises. The dosage might change based on factors like the severity of your condition and how you respond to the medicine. It's important to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you accidentally take more Zerograin 10 Tablet than advised, you may feel drowsy or fatigued, experience stomach pain, or notice an increase in your weight. If these symptoms persist, inform your doctor.

Missed Dose

If you forget to take your regular dose of Zerograin 10 Tablet, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and carry on with your regular schedule. Do not increase your dosage without consulting your doctor.

Store Zerograin 10 Tablet in a cool, dry place, ideally at room temperature of about 25°C.
Keep it away from direct sunlight and moisture to protect its potency.
Ensure the medicine is out of reach and sight of children for their safety.
Check the expiry date on the packet before use and do not use it beyond that date.

To help manage migraines, limit your intake of foods known to trigger headaches like chocolates, cheese, and caffeine. Every person's triggers may differ, so keep a food diary to identify yours.
Regular physical activity can reduce the frequency and intensity of migraines. Incorporate low-impact exercises like yoga or walking into your daily routine.

Fact Box

Drug Category	Calcium Channel Blocker
Therapeutic Category	Antimigraine
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Migraine, Dizziness, Vertigo

What Is Zerograin 10 Tablet Used for?

It's primarily used to manage and prevent migraine headaches, especially those accompanied by dizziness, vertigo, or aura.

How Does Zerograin 10 Tablet Work?

Zerograin 10 Tablet contains flunarizine which blocks calcium entry into neurons, reducing their excitability and preventing abnormal dilation of brain blood vessels.

How Should I Take Zerograin 10 Tablet?

Take this medicine orally with water. It can be consumed with or without food. Aim to take it at the same time each day for best results.

What If I Miss a Dose of Zerograin 10 Tablet?

If you miss a dose, take it as soon as you remember. However, skip the missed dose if it's almost time for the next one.

What Are the Side Effects of Zerograin 10 Tablet?

Common side effects include drowsiness, weight gain due to increased appetite, a low mood, nausea, and muscle aches. Always report persistent side effects to your doctor.

Can I Take Zerograin 10 Tablet With Other Medicines?

Certain medicines can interact with flunarizine causing drowsiness or dizziness. Inform your doctor about all medications and supplements you're taking before starting Zerograin.

How Should I Store Zerograin 10 Tablet?

Store this medicine in a cool, dry place away from direct sunlight and heat. Keep it out of reach of children and pets.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

References

Sibelium. (n.d.). PACKAGE LEAFLET: INFORMATION FOR THE USER - Sibelium 5 mg Tablets. https://www.hpra.ie/img/uploaded/swedocuments/bc725729-1dcc-48c0-b451-a3149ca2f886.pdf
AA PHARMA INC. (2010). PRODUCT MONOGRAPH FLUNARIZINE. https://www.aapharma.ca/downloads/en/PIL/2016/Flunarizine-PM.pdf
National Institute of Child Health and Human Development. (2022, November 30). Flunarizine. Drugs and Lactation Database (LactMed®) - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK525505/
PubChem. (n.d.). Flunarizine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Flunarizine
Flunarizine: uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB04841

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