Zimigut 200 Mg Tablet 10

Zimigut 200 Tablet 10

Intas Pharmaceuticals Ltd

Strip of 10 Units

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MRP ~~₹217.00~~

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₹21.70/Units

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Composition

Rifaximin (200 Mg)

Strength:

200 MG 400 MG 550 MG

Zimigut 200 Tablet 10 is primarily used to manage traveller's diarrhoea caused by specific strains of Escherichia coli (E. coli) bacteria. It is an antibiotic medicine that falls under the class of rifamycin antibacterials.

Apart from this main use, the tablet may be used for other medical conditions where bacterial infection is proven or strongly suspected to be caused by susceptible bacteria. However, it's not recommended for diarrhoea accompanied by fever, blood in stools, or those caused by pathogens other than E. coli.

Before you start taking the medicine, consult your doctor, who will guide you on the correct dosage and frequency based on your health condition. It's important to inform your doctor about any pre-existing diseases or ongoing medication before starting this medicine. If you notice any side effects while on this medicine, notify your doctor immediately. Ensure you continue taking the tablet for the duration your doctor prescribes for optimal results.

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Zimigut 200 Tablet 10 is used for the following:

Managing traveller's diarrhoea caused by non-invasive strains of Escherichia coli in adults and children aged 12 and above.
Treating adults with irritable bowel syndrome with diarrhoea (IBS-D).
Reducing the risk of recurrent overt hepatic encephalopathy (HE) in adults.

Directions for Use of Zimigut 200 Tablet 10

Swallow the whole tablet with water.
Do not crush or chew the tablet.
Complete the entire course as prescribed by your doctor, even if symptoms improve earlier.
Always consult your doctor for specific advice on taking this medicine.

Zimigut 200 Tablet 10 is taken orally.

Zimigut 200 Tablet 10 may cause the following side effects:

Headache
Abdominal pain
Nausea
Vomiting
Constipation
Fatigue
Fever

Managing the Side Effects:

Most side effects are temporary and generally harmless, and they resolve when you discontinue taking Zimigut 200 Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips to manage common side effects:

Nausea: This medicine can be taken with food to reduce this effect.
Abdominal pain: If Zimigut 200 Tablet 10 causes stomach discomfort, consider taking it after food.

Zimigut 200 Tablet 10 contains rifaximin (200 mg). This active ingredient works in the body in the following ways:

Binding to Bacterial RNA Polymerase: Rifaximin binds to a component of the bacterial cell called DNA-dependent RNA polymerase. This enzyme plays a crucial role in bacterial reproduction.
Inhibition of Bacterial RNA Synthesis: By binding to RNA polymerase, rifaximin blocks a stage in transcription, which is vital for bacterial reproduction and growth. This action effectively prevents the growth and multiplication of susceptible bacteria within your gut that cause infectious diarrhoea.

Pregnancy

Caution is advised while taking Zimigut 200 Tablet 10 if you are pregnant. This medicine can cause foetal harm, and it is advised to consult your doctor before taking this medicine.

Breastfeeding

It is unknown whether rifaximin, the active ingredient in Zimigut 200 Tablet 10, is excreted in human milk. Therefore, it's advisable to consult your doctor before using this medicine if you are breastfeeding.

Alcohol

Caution is advised when consuming alcohol if this medication is prescribed to you, to avoid any adverse effects.

Liver

Zimigut 200 Tablet 10 should be used with caution in patients with severe liver impairment. It is recommended that you discuss any liver-related issues with your doctor before starting this medicine.

Kidney

Caution is advised while taking this medication, if you suffer from kidney disease. Inform your doctor if you have a history of kidney problems .

Using Machines & Driving

Zimigut 200 Tablet 10 doesnot typically affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or fatigue, avoid such activities until they subside or consult your doctor.

Allergy

If you are allergic to rifaximin or any other rifamycin-class antibacterial agents, avoid using Zimigut 200 Tablet 10. Always consult your doctor before starting a new medication.

Children

The safety and efficacy of Zimigut 200 Tablet 10 have not been established for children under 12. Always consult the doctor before giving this medicine to a child.

Older Patients

Older patients may be more susceptible to certain side effects of Zimigut 200 Tablet 10. If you are above 70 years of age, it is advisable to take this medicine under medical supervision. Your doctor will guide you based on your overall health status.

Drug-Drug Interactions

Zimigut 200 Tablet 10 interacts with the following medicines:

Anticoagulants: Medicines like warfarin might interact with Zimigut 200 Tablet 10. This could affect how quickly your blood clots, so you may need to adjust your warfarin dosage and monitor your prothrombin time/INR more closely.
CYP3A4-metabolised medicines: Zimigut 200 Tablet 10 may interact with medicines metabolised by the CYP3A4 enzyme. Although specific interactions have not been confirmed, caution should be exercised when taking medications such as erythromycin or ketoconazole.

Drug-Food Interactions

None

Drug-Disease Interactions

Zimigut 200 Tablet 10 interacts with the following diseases:

Severe Liver Impairment: If you have severe liver disease (Child-Pugh Class C), use Zimigut 200 Tablet 10 cautiously. This is because there is an increased chance of the medicine being absorbed into your body, which could potentially lead to side effects.
Clostridium Difficile-Associated Diarrhoea (CDAD): There have been reports of CDAD occurring with almost all antibacterial medicines, including Zimigut 200 Tablet 10. If you have this condition, it is essential to manage it carefully while taking this medication.

Daily Dose

Always take the recommended dose of Zimigut 200 Tablet 10 as per your doctor's instructions. The dosage may vary based on individual factors, such as how severe your condition is and how you respond to the medicine. It is essential to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

In case of an accidental overdose, you might experience side effects such as headaches, abdominal pain, or nausea. If these symptoms persist or worsen, itis advisable to consult your doctor.

Missed Dose

If you realise you have missed a dose of Zimigut 200 Tablet 10, take it as soon as you remember. However, if it is close to your next dose, skip the missed one and continue with your regular schedule. Never increase your dosage without consulting your doctor.

Keep Zimigut 200 Tablet 10 in a cool, dry place.
Protect it from direct sunlight.
Avoid areas with high humidity or moisture.
Always keep this medicine beyond the reach of children.
Remember to use your Zimigut 200 Tablet 10 before its expiry date.

Drink plenty of fluids when taking Zimigut 200 Tablet 10, as it is used to manage traveller's diarrhoea. Staying well-hydrated helps replace lost fluids and prevent dehydration.
Since Zimigut 200 Tablet 10 is an antibiotic, consuming probiotic-rich foods like yoghurt can be beneficial. Probiotics may help restore the natural balance of bacteria in your gut, which antibiotics can disrupt.

Fact Box

Drug Category	Antibiotic
Therapeutic Category	Antibacterial
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Traveler's Diarrhoea, E. coli Infections

What is Zimigut 200 Tablet 10?

Zimigut 200 Tablet 10 is an antibiotic in the rifamycin class primarily used to manage traveller's diarrhoea.

How does Zimigut 200 Tablet 10 work?

This medicine acts in your gut, blocking bacterial RNA synthesis, which stops bacteria from growing and multiplying and manages your diarrhoea.

Can I crush or chew Zimigut 200 Tablet 10?

No, you should swallow the whole tablet . Crushing or chewing it might alter, how the medicine works in your body. Please consult your doctor for the best advice.

What if I miss a dose of Zimigut 200 Tablet 10?

If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed one. Never adjust your dosage without consulting your doctor.

Can Zimigut 200 Tablet 10 cause red-coloured urine?

Yes, rifaximin in Zimigut 200 Tablet 10 can cause harmless reddish discolouration of your urine. Consulting your doctor before hand is a wise step.

What should I do if my diarrhoea symptoms worsen or persist with Zimigut 200 Tablet 10?

If symptoms persist or worsen after 24-48 hours of starting the medicine, you should consult your doctor immediately.

Is there anything I should avoid while taking Zimigut 200 Tablet 10?

While taking this medicine, avoid skipping doses or stopping early, as it could reduce its effectiveness and increase bacterial resistance. Consult your doctor for individualised directions and advice.

Certified Content

Written by

Dr. Pauravi Abad

Medical Writer & Reviewer | 4 years

MBBS

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

References

U.S. National Library of Medicine. (2022). Rifaximin: MedlinePlus Drug Information. MedlinePlus. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a604027.html
U.S. Food and Drug Administration. (2022). Drug Approval Package: Xifaxan (rifaximin) Tablets. FDA. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/021361s029lbl.pdf
Robertson, K. D., & Nagalli, S. (2023, May 22). Rifaximin. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK562329/
Rifaximin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01220
Koo, H. L., & DuPont, H. L. (2010). Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases. Current Opinion in Gastroenterology, 26(1), 17–25. https://doi.org/10.1097/mog.0b013e328333dc8d

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