Zoryl M 0.5 Tablet 20

Intas Pharmaceuticals Ltd

Strip of 20 Units

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MRP ~~₹94~~

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Composition

Glimepiride (0.5 Mg) + Metformin (500 Mg)

Zoryl-M 0.5 Tablet is employed to manage type 2 diabetes mellitus in adults. This oral medication is a combination medicine, part of a group known as antidiabetic agents.

Apart from its primary application, this medicine can also help to improve blood sugar control in adults when diet and exercise alone do not provide satisfactory results. The use of this medicine is not limited to managing type 2 diabetes; it's also used when single-agent therapy using either of its components fails to bring about adequate glycemic control.

Before starting on this medicine, it's important you consult your doctor who will advise on the appropriate dosage and frequency. Please ensure you inform your doctor about any pre-existing health conditions or ongoing medications that you're taking. If you notice any side effects while on this medication, notify your doctor immediately. It's crucial that you continue taking the medication for the duration prescribed by your doctor for the best outcomes.

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Zoryl-M 0.5 Tablet is used for:

Managing type 2 diabetes in adults when the body is resistant to insulin or produces insufficient insulin
Assisting in blood glucose control when diet and exercise alone are insufficient
Complementing single-agent therapy when glimepiride or metformin alone doesn't adequately control blood sugar

Directions for Use of Zoryl M 0.5 Tablet 20

You should take Zoryl-M 0.5 Tablet as follows:

Swallow the tablet whole with a glass of water.
Don't chew, crush, or cut the tablet.
Aim to take the medicine at the same time each day to maintain consistent blood glucose control.
For precise dosage and duration recommendations, ensure you consult your doctor.

Zoryl-M 0.5 Tablet is taken orally.

Taking Zoryl-M 0.5 Tablet might have the following side effects:

Nausea
Vomiting
Diarrhoea
Abdominal pain
Headache
Hypoglycaemia: This is a condition where your blood sugar levels may fall below normal, causing symptoms like dizziness, confusion, and weakness.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Zoryl-M 0.5 Tablet. However, if you experience any serious side effects or worsening of any symptoms, please consult your doctor. To manage common side effects:

Nausea or Vomiting: Consider taking Zoryl-M 0.5 Tablet with food to possibly lessen these effects.
Hypoglycaemia: Try to maintain regular meal timings when taking this medication to avoid sudden drops in blood sugar levels.

Zoryl-M 0.5 Tablet comprises two active ingredients:

Glimepiride (0.5 mg): This sulfonylurea works by encouraging the pancreatic beta cells in your body to release insulin. Insulin is a hormone that helps lower blood sugar levels. When Glimepiride binds with certain receptors on these cells, it triggers them to release insulin.
Metformin (500 mg): Identified as a biguanide, metformin functions by reducing glucose production in your liver. It enhances insulin sensitivity and encourages glucose uptake by peripheral tissues – parts of your body like muscles where glucose is used as energy. This ingredient activates an enzyme known as adenosine monophosphate-activated protein kinase (AMPK), which plays a vital role in controlling how cells process energy.

Pregnancy

Taking Zoryl-M 0.5 Tablet during pregnancy, especially in the second and third trimesters, is not recommended. If you are pregnant or planning to conceive, it's crucial to consult your doctor before starting this medicine.

Breastfeeding

Zoryl-M 0.5 Tablet is not suitable for lactating women as metformin can pass into breast milk. Therefore, breastfeeding while taking this medication should be avoided.

Alcohol

Alcohol should be avoided when taking Zoryl-M 0.5 Tablet due to the increased risk of lactic acidosis. It's best to discuss this with your doctor for a better understanding of potential risks.

Liver

Patients with liver problems should use Zoryl-M 0.5 Tablet with caution as it can affect liver function. Consult your doctor before beginning this medication if you have any liver-related health issues.

Kidney

Zoryl-M 0.5 Tablet is not recommended for those with severe kidney impairment. If you have kidney problems, it's advisable to discuss them with your doctor before starting this medicine.

Using Machines & Driving

There is no specific information available about the effect of Zoryl-M 0.5 Tablet on driving or operating machinery. However, if you experience any side effects that may affect your ability to concentrate or react, refrain from such activities and consult your doctor immediately.

Allergy

If you have known allergies to glimepiride or metformin, or any other ingredients present in Zoryl-M 0.5 Tablet, avoid using this medicine. Discuss alternative options with your doctor.

Children

Zoryl-M 0.5 Tablet is not recommended for use in children as its safety and effectiveness in paediatric patients have not yet been established.

Older Patients

Older patients, especially those with reduced kidney function, should use Zoryl-M 0.5 Tablet cautiously. Start with a lower dose and adjust based on your blood sugar control and kidney function. Always take this medicine under the guidance of your doctor.

Drug-Drug Interactions

Zoryl-M 0.5 Tablet may interact with the following medicines:

Corticosteroids: Medicines like prednisone and dexamethasone can increase blood glucose levels, reducing the effectiveness of this medication.
Diuretics: Thiazide diuretics such as hydrochlorothiazide can also increase blood glucose levels, potentially lessening this medicine's impact.
Sympathomimetic Agents: Medicines like epinephrine and albuterol can raise blood glucose levels, potentially reducing the efficacy of Zoryl-M 0.5 Tablet.

Drug-Food Interactions

Zoryl-M 0.5 Tablet interacts with certain foods:

High-Fat Foods: Consuming high-fat meals may delay the absorption of metformin, one component of this medicine.

Drug-Disease Interactions

Zoryl-M 0.5 Tablet may interact with the following conditions/diseases:

Renal Disease: Patients with severe renal impairment should not take this medication as it could lead to further kidney damage.
Liver Disease: This medication should be used with caution in patients with liver disease as it could exacerbate their condition.
Metabolic Acidosis: Individuals suffering from metabolic acidosis, including diabetic ketoacidosis, should avoid this medicine as it could worsen their condition.

Daily Dose

The daily dose of Zoryl-M 0.5 Tablet is decided by your doctor, based on factors such as your health condition and how your body responds to the medicine. It's crucial to take the medicine as prescribed and not change the dosage without your doctor's approval. For further details regarding dosage, read the package insert.

Over Dose

Accidentally taking more than the prescribed dose of Zoryl-M 0.5 Tablet may cause symptoms like nausea, stomach pain, or dizziness. If you experience these symptoms after an overdose, reach out to your doctor for advice.

Missed Dose

Missed a dose of Zoryl-M 0.5 Tablet? If it's not too close to your next dose time, take it as soon as you remember. But if it's nearly time for your next dose, skip the missed one and continue with your normal schedule. Always remember, don't increase the dose without consulting your doctor.

Keep Zoryl-M 0.5 Tablet in a cool, dry place.
Avoid direct sunlight and moisture.
Keep it away from children.
Make sure to use this medicine before its expiry date.

Since Zoryl-M 0.5 Tablet is used to manage type 2 diabetes, maintain a balanced diet with plenty of fresh vegetables, fruits, and lean proteins. Limit your intake of sugary foods and drinks.
Regular physical activity, like brisk walking or cycling, can help control your blood sugar levels; however, consult your doctor before starting any new exercise regimen.

Fact Box

Drug Category	Sulfonylurea, Biguanide
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes

What is Zoryl-M 0.5 Tablet used for?

Zoryl-M 0.5 Tablet is used to manage type 2 diabetes in adults when diet, exercise and single-agent therapy aren't providing enough blood sugar control.

How does Zoryl-M 0.5 Tablet work?

This medicine combines two active ingredients: glimepiride, which stimulates insulin release from the pancreas, and metformin, which reduces glucose production in the liver.

Can I take Zoryl-M 0.5 Tablet if I'm pregnant or breastfeeding?

It's not recommended to take Zoryl-M 0.5 Tablet during pregnancy, especially in the later stages, or while breastfeeding. Always consult your doctor.

What should I do if I miss a dose of Zoryl-M 0.5 Tablet?

If you miss a dose, take it as soon as you remember. However, if it's near the time for your next dose, skip the missed one.

What are the common side effects of Zoryl-M 0.5 Tablet?

Common side effects include nausea, vomiting, diarrhoea, abdominal pain and headache but these usually improve as your body adjusts to the medicine.

Can I drink alcohol while taking Zoryl-M 0.5 Tablet?

Avoid alcohol intake while on this medication as it can increase the risk of lactic acidosis a rare but serious condition that can be fatal.

How should I store my Zoryl-M 0.5 Tablets?

Store your tablets at room temperature, protect them from moisture and keep them out of reach of children.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 9 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

References

Unknown. (n.d.). Metformin hydrochloride Prolonged Release & Glimepiride tablets I.P. [Pharmaceutical Information]. https://www.sanofi.in/dam/jcr:6c1f15ea-d4af-4e93-b38c-91a76293b247/Amaryl%20M%20-%20PI.pdf
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
AMARYL. (n.d.). AMARYL (glimepiride tablets) 1, 2, and 4 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Glimepiride: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00222

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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