Zoryl Mv 2 Mg Tablet 15

Zoryl Mv 2 Tablet 15

Intas Pharmaceuticals Ltd

STRIP of 15 Units
Pack of 10 Units

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MRP ~~₹423.50~~

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Composition

Glimepiride (2 Mg) + Metformin (500 Mg) + Voglibose (0.2 Mg)

Zoryl-MV 2 Tablet is primarily used to manage type 2 diabetes mellitus. It is a combination medicine that belongs to the class of oral antidiabetic medications. This medicine is particularly useful when single or dual therapy with other oral antidiabetic medicines fails to maintain adequate glycemic control.

Besides this main use, this tablet can also assist in improving the body's overall response to insulin, a natural substance that regulates the amount of glucose in the blood. It aids in controlling high blood sugar levels, preventing kidney damage, blindness, nerve problems, loss of limbs and sexual function problems.

The dosage and frequency of this medicine should be strictly as directed by your doctor. Before starting this medication, it is crucial to inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects while on this medicine, notify your doctor immediately. Continue taking the medication for the duration prescribed by your doctor for optimal results.

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Zoryl-MV 2 Tablet is used for managing the following conditions:

Regulating high blood sugar levels in adults with type 2 diabetes mellitus

Directions for Use of Zoryl Mv 2 Tablet 15

Here are some instructions to keep in mind while taking Zoryl-MV 2 Tablet:

Swallow the tablet whole with a glass of water.
Do not split, chew, or crush the tablet.
Always take this medicine with meals, preferably at breakfast.
Do not increase your dose without consulting your doctor.
If you plan to stop taking this medicine, make sure you speak to your doctor first.

Zoryl-MV 2 Tablet is taken orally.

Zoryl-MV 2 Tablet may have the following common side effects:

Hypoglycemia
Dizziness
Nausea and vomiting
Diarrhoea
Stomach Upset
Headache

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Zoryl-MV 2 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Try taking Zoryl-MV 2 Tablet with food or milk to lessen this effect.
Diarrhoea: Consider taking this medicine with a meal to reduce the risk of diarrhoea.

Zoryl-MV 2 Tablet contains three active ingredients that work together to control high blood sugar levels:

Glimepiride (2 mg): Glimepiride stimulates insulin release by binding to specific receptors on pancreatic beta-cells. It also decreases hepatic insulin clearance and may increase insulin sensitivity in peripheral target sites.
Metformin (500 mg): Metformin acts by decreasing glucose production in the liver and reducing intestinal glucose absorption. It also increases insulin sensitivity by enhancing peripheral glucose uptake and utilization.
Voglibose (0.2 mg): Voglibose slows down carbohydrate digestion and absorption by inhibiting alpha-glucosidase enzymes in the small intestine. This action delays glucose absorption thereby lowering post-meal blood sugar levels.

These three components together offer an efficient mechanism to manage high blood sugar levels in adults with type 2 diabetes mellitus.

Pregnancy

When you're pregnant, caution is advised while taking Zoryl-MV 2 Tablet. Having poorly controlled diabetes during pregnancy can increase risks for both mother and baby. It is best to discuss with your doctor if you should continue with this medicine during pregnancy or switch to insulin.

Breastfeeding

It's not recommended to breastfeed while on Zoryl-MV 2 Tablet. Always check with your doctor about the potential risks and benefits.

Alcohol

Avoid excessive alcohol intake while using this medicine. Alcohol can intensify the effect of metformin on lactate metabolism, which might increase the risk of lactic acidosis.

Liver

If you have liver problems, exercise caution when taking Zoryl-MV 2 Tablet. Abnormal liver functioning can affect the metabolism of this medicine. Your doctor can guide you based on your health status.

Kidney

Zoryl-MV 2 Tablet is contraindicated if you have moderate to severe renal impairment, due to the increased risk of lactic acidosis with metformin. Do consult your doctor beforehand if you have any kidney health issues.

Using Machines & Driving

No specific precautions are required when driving or operating machinery during treatment with Zoryl-MV 2 Tablet. However, be aware that hypoglycemia (low blood sugar) can impair your ability to concentrate.

Allergy

If you are allergic to glimepiride, metformin, voglibose or any other ingredients in Zoryl-MV 2 Tablet, refrain from taking this medicine and seek advice from your doctor.

Children

It's advised to consult a doctor before giving this medicine to a child.

Older Patients

For older patients, especially those above 65 years, more frequent assessment of renal function is recommended due to aging associated with reduced kidney function. Consult your doctor before taking Zoryl-MV 2 Tablet.

Drug-Drug Interactions

Zoryl-MV 2 Tablet interacts with the following medicines:

Antihypertensives such as captopril, and enalapril: The concomitant use of this tablet with antihypertensives can increase insulin sensitivity and potentiate blood glucose-lowering effects and may cause hypoglycaemia.
Carbonic anhydrase inhibitors: Medicines like acetazolamide used for glaucoma treatment may increase the risk of lactic acidosis, a side effect of metformin; regular monitoring is advised.
Medicines that reduce metformin clearance: Medicines such as ranolazine (a heart medication), vandetanib (used for thyroid cancer), and dolutegravir (an HIV medicine) can slow down the elimination of metformin from your body, increasing the risk of lactic acidosis.

Drug-Food Interactions

Consuming a diet high in fibre while on this medicine may slow down the absorption of glimepiride, affecting its effectiveness.

Drug-Disease Interactions

Zoryl-MV 2 Tablet interacts with the following diseases:

Hypoxia: Conditions causing low oxygen levels in your body can increase the risk of lactic acidosis from metformin.
Vitamin B12 Deficiency: Long-term use of metformin may lead to low vitamin B12 levels. Monitor these levels regularly if you have this deficiency.

Daily Dose

The daily dose of Zoryl-MV 2 Tablet should be taken as directed by your doctor. The dosage may vary based on individual factors such as the severity of your condition and how you respond to the medication. Always follow the dosage prescribed by your doctor, and never modify it without consulting them first.

Over Dose

If you accidentally take more Zoryl-MV 2 Tablet than instructed, you might experience hypoglycemia or low blood sugar. To combat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins). Seek medical attention if hypoglycemia persists.

Missed Dose

In case you forgot to take your regular dose of Zoryl-MV 2 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not increase your dosage without consulting your doctor.

Store Zoryl-MV 2 Tablet at room temperature below 30°C.
Keep it away from excessive heat and direct light.
Ensure that the medicine is kept in a dry place, protecting it from moisture and humidity.
Always keep Zoryl-MV 2 Tablet out of the reach of children.
Always check the expiry date before using the medicine.

Following a healthy diet low in simple sugars can help manage type 2 diabetes. Try to incorporate more whole grains, fruits, vegetables, and lean proteins into your meals.
Regular physical activity can help increase your body's sensitivity to insulin and help manage your blood glucose level. Aim for at least 30 minutes of moderate exercise like brisk walking or cycling daily.

Fact Box

Drug Category	Sulfonylurea, Biguanide, Alpha-Glucosidase Inhibitor
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus

What is Zoryl-MV 2 Tablet used for?

It's used to manage type 2 diabetes when diet, exercise, and other oral medications are not sufficient in controlling blood sugar levels.

How does Zoryl-MV 2 Tablet work?

It contains three active ingredients that work together to reduce blood sugar levels by increasing insulin release, reducing glucose production, and slowing glucose absorption.

Can I split or crush the Zoryl-MV 2 Tablet?

No, tablets should be swallowed whole without crushing or splitting, preferably with breakfast.

What are the common side effects of Zoryl-MV 2 Tablet?

Some people may experience hypoglycaemia, nausea, diarrhoea, and upper respiratory tract infection while taking this medicine.

Is it safe to take Zoryl-MV 2 Tablet during pregnancy?

When you're pregnant, caution is advised while taking Zoryl-MV 2 Tablet.

What happens if I overdose on Zoryl-MV 2 Tablet?

Overdosing can cause severe hypoglycaemia and lactic acidosis. Immediate medical attention is necessary in such cases.

Should I avoid alcohol when taking Zoryl-MV 2 Tablet?

Yes, excessive alcohol intake can affect lactate metabolism while on this medicine and increase risk of lactic acidosis.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

References

Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Glimepiride: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00222
Voglibose: uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB04878
Amaryl. (n.d.). Metformin hydrochloride (SR), glimepiride, & voglibose tablets [Pharmaceutical]. https://www.sanofi.in/dam/jcr:99ce79b7-f940-4c0e-ae78-225fbf7b45b3/Amaryl%20MV%20PI.pdf
Bantwal, G., Ayyar, V., Kovil, R., Chawla, M., Shah, T., Kumar, S., Abhyankar, M., & Revankar, S. (2021). Assessment of clinical experience of triple drug fixed-dose combination of glimepiride, metformin and voglibose in the management of Type 2 diabetes mellitus: a retrospective study. Journal of Clinical and Diagnostic Research. https://doi.org/10.7860/jcdr/2021/47919.15346

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