Zukanorm M 50500 Mg Tablet 20

Zukanorm M 500 Tablet 20

Mankind Pharmaceuticals Ltd.

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MRP ~~₹163.35~~

₹133.95

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Composition

Metformin (500 Mg) + Vildagliptin (50 Mg)

Zukanorm M 500 Tablet 20 is primarily used to manage type 2 diabetes mellitus. This combination medication falls into the class of oral anti-diabetic agents.

It is also prescribed for improved control of blood sugar levels in adults who have type 2 diabetes and cannot manage their condition via diet and exercise alone. The medicine plays a significant role in reducing both fasting and post-meal blood sugar levels, thus lowering the risk of serious long-term complications such as heart disease, kidney damage, nerve problems, and vision loss.

Inform your doctor about any pre-existing conditions or ongoing medications you're currently on. If you experience any side effects while taking this medication, notify your doctor immediately. Remember to continue taking this medicine for the duration prescribed by your doctor to achieve the best results.

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Zukanorm M 500 Tablet 20 is used to manage Type 2 Diabetes Mellitus.

Directions for Use of Zukanorm M 500 Tablet 20

Here are some steps to follow when taking Zukanorm M 500 Tablet 20:

Swallow the whole tablet with a glass of water.
Avoid splitting, crushing or chewing the tablet.
This medicine should be taken regularly as prescribed by your doctor to maintain steady blood glucose control.
Consult your doctor before altering the dosage or stopping the medication.

Zukanorm M 500 Tablet 20 is taken orally.

Side Effects of Zukanorm M 500 Tablet 20

Zukanorm M 500 Tablet 20 may have the following side effects:

Diarrhoea
Nausea
Vomiting
Abdominal pain
Appetite loss
Upper respiratory tract infections
Nasopharyngitis: Inflammation of the throat or nose due to a common cold.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Zukanorm M 500 Tablet 20. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some simple tips to manage a couple of common side effects:

Diarrhoea: Try taking this medicine with food, as it can help ease this symptom.
Nausea and vomiting: Taking this medicine after meals might help reduce these symptoms.

Zukanorm M 500 Tablet 20 comprises two key components:

Vildagliptin (50 mg): This component selectively inhibits an enzyme called dipeptidyl peptidase-4 (DPP-4). DPP-4 breaks down natural substances called incretins that help control insulin secretion based on glucose levels in your body. Therefore, by inhibiting DPP-4, vildagliptin increases and extends incretin activity, resulting in better regulation of insulin secretion and lower glucose levels with minimal risk of hypoglycaemia.
Metformin (500 mg): This ingredient reduces sugar production in the liver, decreases sugar absorption in the gut, and improves insulin sensitivity, which enhances glucose uptake and utilization by tissues like muscles.
These two components work together effectively to improve insulin sensitivity, reduce liver-produced glucose, enhance glucose-dependent insulin secretion, and manage blood sugar levels in individuals with type 2 diabetes.

Pregnancy

Caution is advised while taking Zukanorm M 500 Tablet 20 if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

Breastfeeding women should exercise caution while taking this medicine. Consult your doctor before starting on Zukanorm M 500 Tablet 20 to understand the potential risks and benefits.

Alcohol

Avoid excessive alcohol consumption whilst taking Zukanorm M 500 Tablet 20 as it may increase the risk of lactic acidosis, a potential side effect of metformin.

Liver

This medicine is not recommended if you have severe liver problems. If you have mild to moderate liver issues, discuss them with your doctor before starting on this medication.

Kidney

If you have a history of kidney problems, caution is advised before using Zukanorm M 500 Tablet 20. It's a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

This medicine may cause side effects affecting your ability to drive or operate machinery. Ensure you know how this medication affects you before undertaking such activities.

Allergy

Do not take Vidalip M 500 mg/50 mg Tablet if you are allergic to metformin, vildagliptin, or any other ingredients. Always inform your doctor about any known allergies beforehand.

Children

This medicine is not intended for use in children under the age of 18 years. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take this medication under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Interactions of Zukanorm M 500 Tablet 20

Drug-Drug Interactions

Zukanorm M 500 Tablet 20 can interact with the following medicines:

Cationic Medications: Metformin, an active ingredient in Zukanorm M 500 Tablet 20, may interact with medications like amiloride, digoxin, and trimethoprim, resulting in increased plasma concentrations of these agents.
Iodinated Contrast Agents: When used together with Zukanorm M 500 Tablet 20, these agents may cause acute renal failure and lactic acidosis. So, it's wise to temporarily stop taking this medication during such procedures.
CYP3A4 inducers: Medicines like rifampicin can reduce the efficacy of vildagliptin, another active ingredient in Zukanorm M 500 Tablet 20.

Drug-Food Interactions

No specific food interactions have been reported with Zukanorm M 500 Tablet 20.

Drug-Disease Interactions

Zukanorm M 500 Tablet 20 may interact with the following diseases:

Renal Impairment: People with kidney diseases should avoid using this medicine as the kidneys predominantly excrete metformin.
Diabetic Ketoacidosis: This medication is not suitable for people suffering from diabetic ketoacidosis.
Severe Hepatic Dysfunction: Those with severe liver disease should refrain from using this medication as it might exacerbate their condition.

Daily Dose

Your daily dose of Zukanorm M 500 Tablet 20 should be as your doctor prescribes. The dosage can vary depending on factors like the severity of your condition and how you respond to treatment. Always follow your doctor's prescribed dosage and never alter it without consulting your doctor first.

Over Dose

Overdosing on Zukanorm M 500 Tablet 20 may lead to symptoms such as nausea, diarrhoea, and stomach pains. If you suspect an overdose, it's crucial to inform your doctor promptly. Never take more than the prescribed dose.

Missed Dose

If you forget to take a dose of Zukanorm M 500 Tablet 20, take it as soon as you remember. However, if it's nearly time for your next scheduled dose, skip the one you missed and continue with your regular schedule. It's important not to double your dose without discussing it with your doctor.

Keep Zukanorm M 500 Tablet 20 in a cool, dry place.
Avoid direct exposure to sunlight, heat, and moisture.
Ensure the medicine is out of reach of children.
Always check and respect the expiry date before taking the medicine.

Incorporate foods rich in fibre and low in sugar into your diet to manage blood glucose levels effectively, aiding Zukanorm M 500 Tablet 20's function.
Regular physical activity, such as a brisk 30-minute walk daily, can improve insulin sensitivity and improve diabetes management.

Fact Box

Drug Category	Biguanide Antidiabetic, DPP-4 Inhibitor
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes

What is Zukanorm M 500 Tablet 20 used for?

This medicine is used to manage high blood sugar levels in adults with type 2 diabetes, alongside diet and exercise.

How does Zukanorm M 500 Tablet 20 work?

It contains metformin and vildagliptin, which together help improve insulin sensitivity and reduce glucose levels.

Can anyone take Zukanorm M 500 Tablet 20?

No, it's not suitable for people with type 1 diabetes, kidney issues, metabolic acidosis or severe liver disease.

How should Zukanorm M 500 Tablet 20 be taken?

It should be taken orally and as prescribed by the doctor. Always swallow the tablet whole without crushing or chewing it.

What are some side effects of Zukanorm M 500 Tablet 20?

Common side effects include nausea, vomiting, diarrhoea and loss of appetite. Contact your doctor if these symptoms persist or worsen.

Can I drink alcohol while taking Zukanorm M 500 Tablet 20?

Avoid excessive alcohol consumption as it may increase the risk of lactic acidosis, a severe side effect.

Where should I store Zukanorm M 500 Tablet 20?

Store it in a cool, dry place below 30°C, away from direct sunlight and out of reach of children.

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

208, Okhla Industrial Estate, Phase-III, New Delhi South Delhi DL 110020 IN

Country of origin: INDIA

References

Medlineplus. (n.d.). Metformin. Retrieved from https://medlineplus.gov/druginfo/meds/a696005.html
National Center for Biotechnology Information. (2010). Vildagliptin: a new oral treatment for type 2 diabetes mellitus. Retrieved from https://pubmed.ncbi.nlm.nih.gov/20964454/
Vildagliptin: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB04876
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 6918537, Vildagliptin. Retrieved June 16, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Vildagliptin.
Metformin: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331

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