D Fresh Gel is a pain reliever that is applied to the skin. It works by preventing the release of chemical messengers that cause inflammation and pain. It also increases blood circulation and has a cooling impact on the skin at the application location. Depending on the severity of your problem, D Fresh Spray can be used 2 to 4 times each day to the affected area. It should be applied to the skin slowly and evenly until it is rubbed in. It should not be used too frequently, and the treated region should not be covered with a bandage or plaster.