Amlodipine + Bisoprolol

Dosage Forms Available

• Amlodipine + Bisoprolol is available as tablets for oral use.

Age and Dose Restrictions

• This combination is intended for adults only.

Contraindications

• Amlodipine + Bisoprolol is contraindicated in patients who have known allergies to either amlodipine or bisoprolol.

• It should not be used by those suffering from cardiogenic shock, severe bradycardia (very slow heartbeat), second or third-degree heart block, sick sinus syndrome, severe liver impairment, or untreated pheochromocytoma (adrenal gland tumour).

Other Medications to Avoid

• This combination may interact with other blood pressure medicines (e.g., lisinopril, metoprolol), heart rhythm medicines (e.g., amiodarone, propafenone), antibiotics (e.g., rifampicin), antidepressants (e.g., fluoxetine, paroxetine), and herbal supplements (e.g., St. John's wort).

Overdose and Missed Dose

• An overdose of this combination medicine can lead to symptoms like extremely low blood pressure and slow heartbeat. If these occur, seek immediate medical attention.

• If you forget to take this medicine, take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water can help manage side effects like headache, dizziness, and fatigue.

• Resting and avoiding sudden movements can help manage dizziness.

Use in Driving and Operating Machinery

• Amlodipine + Bisoprolol can cause side effects such as dizziness or fatigue, which may affect your ability to drive or operate heavy machinery. It is advised to avoid such activities until you know how this medication affects you.

Use in Pregnancy and Lactation

• This medicine is not approved for use during pregnancy and its safety during breastfeeding is not established. Consult your doctor if you are pregnant or breastfeeding before using this medicine.

Caution in Other Conditions

• Patients with severe liver or kidney disease, asthma or other breathing problems, peripheral artery disease, thyroid problems, diabetes, or certain heart conditions like heart block or slow heartbeat should exercise caution when taking this combination.

Special Dietary and Lifestyle Recommendations

• Avoid grapefruit and grapefruit juice as they may increase the blood levels of amlodipine.

• Reduce your intake of high-salt foods as excess sodium can counteract the blood pressure-lowering effect of this medicine.