Atorvastatin + Ezetimibe
Uses of Atorvastatin + Ezetimibe
Atorvastatin + Ezetimibe is mainly used to manage high cholesterol levels and belongs to the group of statin medicines combined with cholesterol absorption inhibitors.
It is also often used in patients with increased cardiovascular risk, such as those with multiple cardiovascular risk factors or familial hypercholesterolemia, to reduce the risk of heart attack, stroke, and other complications related to high cholesterol.
Side effects of Atorvastatin + Ezetimibe
Nasopharyngitis
Diarrhoea
Joint pain
Muscle pain
Fatigue
How Atorvastatin + Ezetimibe works
Atorvastatin is a statin. It blocks a key enzyme necessary for cholesterol synthesis in the liver. This action reduces levels of "bad" LDL cholesterol and triglycerides and increases "good" HDL cholesterol.
Ezetimibe is a cholesterol-lowering medication. It selectively inhibits cholesterol absorption in the small intestine. This prevents the delivery of cholesterol to the liver. Working together, these two components effectively reduce LDL cholesterol by inhibiting both its synthesis in the liver and its absorption in the intestines.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Atorvastatin + Ezetimibe can be taken orally (tablet).
Age and Dose Restrictions
This combination is generally recommended for use in adults.
Contraindications
This medication is contraindicated in patients diagnosed with active liver disease or unexplained persistent elevations in hepatic transaminases. It is also contraindicated for patients who have a known hypersensitivity to any component of this medication.
Other Medications to Avoid
Atorvastatin + Ezetimibe may interact with certain medications, such as immunosuppressant medicines (like cyclosporine), cholesterol-modifying medicines (like fibrates), heart rhythm medications (like digoxin), and antibiotics (like rifampin).
Overdose and Missed Dose
An overdose of Atorvastatin + Ezetimibe can result in complications like muscle pain and weakness, muscle breakdown, and liver damage. If you suspect an overdose, immediately seek medical attention.
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not double up the dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.
Drinking plenty of water can help manage side effects like headaches and dry mouth.
Resting or taking a short nap can help if dizziness or fatigue occurs.
Use in Driving and Operating Machinery
Atorvastatin + Ezetimibe can cause dizziness or fatigue. If you experience these symptoms, avoid driving or operating heavy machinery until you feel well enough.
Use in Pregnancy and Lactation
Atorvastatin + Ezetimibe is not recommended for use during pregnancy and lactation.
Caution in Other Conditions
Patients with renal impairment, hepatic impairment, or thyroid disorders should exercise caution when taking Atorvastatin + Ezetimibe.
A regular liver function test is recommended for patients on this medication as it can cause changes in liver enzymes.
Special Dietary and Lifestyle Recommendations
Limit intake of saturated fats, trans fats, and dietary cholesterol.
Regular check-ups with your doctor and routine cholesterol screenings can help monitor your progress and adjust your treatment plan if necessary.
Frequently asked questions
Can Atorvastatin + Ezetimibe be used for long-term management of cholesterol?
Yes, Atorvastatin + Ezetimibe can be used for long-term management of cholesterol levels. However, it is important to follow your doctor's instructions regarding the duration of use.
Can I stop using Atorvastatin + Ezetimibe once my cholesterol levels normalize?
Do not stop taking Atorvastatin + Ezetimibe without consulting your doctor. The medication manages your cholesterol levels but does not cure the condition.
Can Atorvastatin + Ezetimibe affect my mood or behaviour?
Atorvastatin + Ezetimibe does not affect mood or behaviour. However, if you notice any changes in your mood or behaviour, please consult your doctor.
Does Atorvastatin + Ezetimibe have an impact on weight loss?
Atorvastatin + Ezetimibe does not have a direct impact on weight loss. But maintaining a healthy weight is crucial in managing high cholesterol levels.
Can Atorvastatin + Ezetimibe cause weight gain?
Weight gain is not a commonly reported side effect of Atorvastatin + Ezetimibe. However, if you notice any unusual changes in your weight, you should report this to your doctor.
How long does it take for Atorvastatin + Ezetimibe to start showing its effect?
While Atorvastatin + Ezetimibe begins working soon after you take it, it may take about 2-4 weeks to see the full effect on cholesterol levels. However, the exact period may vary depending on your health condition.
Does Atorvastatin + Ezetimibe have any effect on menstruation?
No, Atorvastatin + Ezetimibe is not known to affect menstruation. If you experience any changes in your menstrual cycle while taking this medication, consult your doctor.
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