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Benzalkonium Chloride + Brimonidine + Timolol

Uses of Benzalkonium Chloride + Brimonidine + Timolol

  • Benzalkonium Chloride + Brimonidine + Timolol is mainly used for managing elevated intraocular pressure associated with open-angle glaucoma or ocular hypertension. It belongs to the group of glaucoma medications.

Side effects of Benzalkonium Chloride + Brimonidine + Timolol

  • Eye irritation (redness, burning, stinging, itching)

  • Dryness of the eyes or mouth

  • Fatigue or drowsiness

  • Blurred vision

  • Unusual taste in the mouth

How Benzalkonium Chloride + Brimonidine + Timolol works

  • Benzalkonium Chloride + Brimonidine + Timolol is an intraocular pressure-lowering ophthalmic combination.

  • Benzalkonium Chloride acts as an antimicrobial preservative in this combination. It ensures that the solution remains sterile for safe use.

  • Brimonidine is an alpha-2 adrenergic agonist. It binds to alpha-2 adrenergic receptors in the eye, which reduces the formation of aqueous humour and increases its outflow. Aqueous humour is a clear fluid in the front of the eye, and its increased outflow helps lower the pressure within the eye.

  • Timolol is a non-selective beta-adrenergic receptor-blocking agent. It works by slowing down the production of aqueous humour, further helping to decrease intraocular pressure.

  • Together, these three components work in synergy to manage conditions like open-angle glaucoma or ocular hypertension by effectively lowering intraocular pressure.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Benzalkonium Chloride + Brimonidine + Timolol is available as a sterile ophthalmic solution.

Age and Dose Restrictions

  • This combination is meant for adults and children older than 2 years due to potential severe adverse effects in younger children.

Contraindications

  • This combination is contraindicated in patients with hypersensitivity to any of its components.

  • It is also contraindicated in individuals with bronchospasm or bronchial asthma, severe COPD, sinus bradycardia, 2nd or 3rd degree AV block, cardiogenic shock, and overt heart failure.

Other Medications to Avoid

  • This combination may interact with beta-blockers (such as atenolol and propranolol), calcium channel blockers (such as amlodipine and verapamil), catecholamine-depleting medicines (like reserpine), antiarrhythmics (including amiodarone and sotalol), digitalis (such as digoxin), CYP2D6 inhibitors (like fluoxetine and paroxetine), tricyclic antidepressants (such as amitriptyline and imipramine), barbiturates (including phenobarbital), phenothiazines (like chlorpromazine), monoamine oxidase inhibitors (such as selegiline and phenelzine), and oral carbonic anhydrase inhibitors (like acetazolamide).

Overdose and Missed Dose

  • An overdose of Benzalkonium Chloride + Brimonidine + Timolol might lead to an exacerbation of side effects such as dizziness, slow heart rate, or respiratory difficulties. In such cases, immediate medical attention is essential.

  • In case you happen to put a few extra drops in your eye, do not panic. Rinse your eyes with clean water at room temperature. If any symptoms persist or worsen, inform your doctor.

  • If you miss a dose of this combination, administer it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For dry eyes or mouth that may occur as side effects, sipping water throughout the day can be helpful.

  • For minor eye irritation or redness, resting your eyes periodically can be beneficial.

Use in Driving and Operating Machinery

  • This combination can cause visual disturbances such as blurred vision, which may affect your ability to drive or operate heavy machinery. It is advisable to avoid these activities if these symptoms occur.

Use in Pregnancy and Lactation

  • The safety of using Benzalkonium Chloride + Brimonidine + Timolol during pregnancy and lactation has not been established. Therefore, it is recommended to consult your doctor before using this combination if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Individuals with diabetes or hypoglycemia, thyroid disorders, and kidney or liver problems should use this combination with caution.

Special Dietary and Lifestyle Recommendations

  • To support overall eye health and potentially aid in managing conditions like glaucoma, which this medication addresses, consider incorporating foods rich in antioxidants such as leafy greens, berries, and nuts into your diet.

  • Maintaining a healthy weight helps reduce the risk of developing complications related to ocular hypertension.

  • Avoidance of excessive caffeine and high-sodium foods may be beneficial in managing intraocular pressure.

Frequently asked questions

Yes, though rare, some patients might be allergic to Benzalkonium Chloride + Brimonidine + Timolol or any of its ingredients. Symptoms of an allergic reaction include rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing. If such symptoms occur, contact your doctor immediately.

No specific mood changes have been linked to the use of Benzalkonium Chloride + Brimonidine + Timolol. However, if you experience unusual mood swings or other psychological effects while using this combination, it is recommended that you consult your doctor.

No, it is not a steroid. It is a combination of two types of medicines: an alpha-2 adrenergic agonist and a beta blocker.

There is no evidence to suggest that this combination will affect your fertility. However, if you are trying to conceive, it is always best to discuss this with your doctor.

No, there is no evidence to suggest that this combination can lead to dependency. However, it should always be used as prescribed by your doctor.

There are no specific dietary restrictions while taking this combination. However, it is always good to maintain a balanced diet for overall health.

This combination is often prescribed for daily use. However, it should be taken exactly as directed by your doctor.

Terms & Conditions


Benzalkonium Chloride + Brimonidine + Timolol in other salts

BRIMONIDINE + TIMOLOLBENZALKONIUM CHLORIDE + CHOLINE SALICYLATE + LIDOCAINE / LIGNOCAINEBENZALKONIUM CHLORIDE + ZINC OXIDEBENZALKONIUM CHLORIDE + BROMFENAC + MOXIFLOXACINBENZALKONIUM CHLORIDE + OFLOXACINBENZALKONIUM CHLORIDE + CYCLOPENTOLATEBENZALKONIUM CHLORIDE + CIPROFLOXACINBENZALKONIUM CHLORIDE + CIPROFLOXACIN + DEXAMETHASONEBENZALKONIUM CHLORIDE + FLUOROMETHOLONEBENZALKONIUM CHLORIDE + FLUOROMETHOLONE + TOBRAMYCINBENZALKONIUM CHLORIDE + GATIFLOXACINTIMOLOLBENZALKONIUM CHLORIDE + DEXAMETHASONE + OFLOXACINBENZALKONIUM CHLORIDE + NEPAFENACBENZALKONIUM CHLORIDE + MOXIFLOXACIN + PREDNISOLONEBENZALKONIUM CHLORIDE + TOBRAMYCINOXYCHLORO COMPLEX + TIMOLOLBENZALKONIUM CHLORIDE + CHOLINE SALICYLATEBENZALKONIUM CHLORIDE + DEXAMETHASONE + TOBRAMYCINALCAFTADINE + BENZALKONIUM CHLORIDEBRIMONIDINEBENZALKONIUM CHLORIDE + TIMOLOLBENZALKONIUM CHLORIDE + BRINZOLAMIDEBENZALKONIUM CHLORIDE + FLUCONAZOLEBENZALKONIUM CHLORIDE + KETOROLAC + MOXIFLOXACINBENZALKONIUM CHLORIDE + LATANOPROSTBENZALKONIUM CHLORIDE + OLOPATADINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + BRIMONIDINEBRIMONIDINE + OXYCHLORO COMPLEXBENZALKONIUM CHLORIDE + PHENYLEPHRINE + TROPICAMIDEBENZALKONIUM CHLORIDE + BEPOTASTINEBENZALKONIUM CHLORIDE + BRIMONIDINE + BRINZOLAMIDEBENZALKONIUM CHLORIDE + BIMATOPROSTBENZALKONIUM CHLORIDE + BIMATOPROST + TIMOLOLBENZALKONIUM CHLORIDE + BRINZOLAMIDE + TIMOLOLBRIMONIDINE + BRINZOLAMIDEBIMATOPROST + TIMOLOLBENZALKONIUM CHLORIDE + CYCLOSPORINBENZALKONIUM CHLORIDE + KETOROLAC + OLOPATADINEBENZALKONIUM CHLORIDE + DORZOLAMIDEBENZALKONIUM CHLORIDE + DORZOLAMIDE + TIMOLOLBENZALKONIUM CHLORIDE + GATIFLOXACIN + PREDNISOLONEBENZALKONIUM CHLORIDE + LATANOPROST + TIMOLOLLATANOPROST + TIMOLOLTIMOLOL + TRAVOPROSTBENZALKONIUM CHLORIDE + LOTEPREDNOLBENZALKONIUM CHLORIDE + LOTEPREDNOL + TOBRAMYCINBENZALKONIUM CHLORIDE + DEXAMETHASONE + MOXIFLOXACINBENZALKONIUM CHLORIDE + LOTEPREDNOL + MOXIFLOXACINBENZALKONIUM CHLORIDE + BROMFENACBENZALKONIUM CHLORIDE + MOXIFLOXACINDORZOLAMIDE + TIMOLOLBENZALKONIUM CHLORIDE + OLOPATADINEBENZALKONIUM CHLORIDE + PREDNISOLONEBENZALKONIUM CHLORIDE + TIMOLOL + TRAVOPROSTBENZALKONIUM CHLORIDE + TRAVOPROSTBENZALKONIUM CHLORIDE + NATAMYCINBENZALKONIUM CHLORIDE + CAMPHOR + MENTHOL + NAPHAZOLINE HYDROCHLORIDE + PHENYLEPHRINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + NETARSUDILBRIMONIDINE + OXYCHLORO COMPLEX + TIMOLOLBENZALKONIUM CHLORIDE + GANCYCLOVIR
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