Benzalkonium Chloride + Brimonidine + Timolol

Dosage Forms Available

• Benzalkonium Chloride + Brimonidine + Timolol is available as a sterile ophthalmic solution.

Age and Dose Restrictions

• This combination is meant for adults and children older than 2 years due to potential severe adverse effects in younger children.

Contraindications

• This combination is contraindicated in patients with hypersensitivity to any of its components.

• It is also contraindicated in individuals with bronchospasm or bronchial asthma, severe COPD, sinus bradycardia, 2nd or 3rd degree AV block, cardiogenic shock, and overt heart failure.

Other Medications to Avoid

• This combination may interact with beta-blockers (such as atenolol and propranolol), calcium channel blockers (such as amlodipine and verapamil), catecholamine-depleting medicines (like reserpine), antiarrhythmics (including amiodarone and sotalol), digitalis (such as digoxin), CYP2D6 inhibitors (like fluoxetine and paroxetine), tricyclic antidepressants (such as amitriptyline and imipramine), barbiturates (including phenobarbital), phenothiazines (like chlorpromazine), monoamine oxidase inhibitors (such as selegiline and phenelzine), and oral carbonic anhydrase inhibitors (like acetazolamide).

Overdose and Missed Dose

• An overdose of Benzalkonium Chloride + Brimonidine + Timolol might lead to an exacerbation of side effects such as dizziness, slow heart rate, or respiratory difficulties. In such cases, immediate medical attention is essential.

• In case you happen to put a few extra drops in your eye, do not panic. Rinse your eyes with clean water at room temperature. If any symptoms persist or worsen, inform your doctor.

• If you miss a dose of this combination, administer it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• For dry eyes or mouth that may occur as side effects, sipping water throughout the day can be helpful.

• For minor eye irritation or redness, resting your eyes periodically can be beneficial.

Use in Driving and Operating Machinery

• This combination can cause visual disturbances such as blurred vision, which may affect your ability to drive or operate heavy machinery. It is advisable to avoid these activities if these symptoms occur.

Use in Pregnancy and Lactation

• The safety of using Benzalkonium Chloride + Brimonidine + Timolol during pregnancy and lactation has not been established. Therefore, it is recommended to consult your doctor before using this combination if you are pregnant or breastfeeding.

Caution in Other Conditions

• Individuals with diabetes or hypoglycemia, thyroid disorders, and kidney or liver problems should use this combination with caution.

Special Dietary and Lifestyle Recommendations

• To support overall eye health and potentially aid in managing conditions like glaucoma, which this medication addresses, consider incorporating foods rich in antioxidants such as leafy greens, berries, and nuts into your diet.

• Maintaining a healthy weight helps reduce the risk of developing complications related to ocular hypertension.

• Avoidance of excessive caffeine and high-sodium foods may be beneficial in managing intraocular pressure.