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Benzalkonium Chloride + Netarsudil

Uses of Benzalkonium Chloride + Netarsudil

  • The main use of Benzalkonium Chloride + Netarsudil is for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It belongs to the group of Rho kinase inhibitors and antimicrobial preservatives.

Side effects of Benzalkonium Chloride + Netarsudil

  • Eye redness

  • Deposits in the cornea

  • Eye discomfort

  • Reduced visual acuity

  • Bleeding from the eyes

How Benzalkonium Chloride + Netarsudil works

  • Benzalkonium Chloride + Netarsudil is an ophthalmic solution.

  • Netarsudil is a Rho kinase inhibitor. It increases the outflow of aqueous humor the fluid in our eyes by relaxing specific muscles in the eyes. This allows the fluid to drain more easily, thus reducing pressure inside the eyes.

  • Benzalkonium Chloride acts as an antimicrobial preservative. It kills bacteria and other microorganisms that could contaminate ophthalmic solutions. This compound works by breaking down the cell walls of these microorganisms, causing them to die and preventing them from multiplying and causing infections.

Certified content

Written By

docImg
Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • The combination of Benzalkonium Chloride + Netarsudil is available as an ophthalmic solution.

  • This medicine is administered topically, in the form of eye drops.

Age and Dose Restrictions

  • This medicine is intended for use in adults.

  • It is not to be used by children as the safety and efficacy in pediatric population have not been established.

Contraindications

  • Benzalkonium Chloride + Netarsudil is contraindicated in patients with known hypersensitivity to either benzalkonium chloride or netarsudil.

Other Medications to Avoid

  • Benzalkonium Chloride + Netarsudil may interact with other ocular preservatives (such as thimerosal), antiglaucoma agents (like latanoprost or timolol), and ocular lubricants (like propylene glycol). These interactions may increase the risk of eye irritation, dryness, or reduced efficacy of Netarsudil due to the preservative's potential to disrupt the ocular surface.

Overdose and Missed Dose

  • In case of an overdose, discontinuation of the medication and supportive care is recommended.

  • If you miss a dose, administer it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose and continue with your regular dosing schedule.

  • In case you happen to put a few extra drops in your eye, do not panic. Rinse your eyes with clean water at room temperature. If any symptoms persist or worsen, inform your doctor.

Management of Side Effects

Most side effects are temporary and generally harmless, resolving when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Avoid rubbing your eyes after administering the drops as this may cause irritation.

  • Use lubricating eye drops if you experience dry eyes as a side effect.

Use in Driving and Operating Machinery

  • This medication may affect your vision temporarily and hence it is advisable to avoid driving or operating heavy machinery until your vision is clear.

Use in Pregnancy and Lactation

  • There are no adequate and well-controlled studies of Benzalkonium Chloride + Netarsudil in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

  • Caution should be exercised when this medication is administered to a nursing woman.

Caution in Other Conditions

  • Caution should be exercised while using this medicine in patients with narrow-angle glaucoma, as it may trigger an acute angle-closure attack.

  • Special Dietary and Lifestyle Recommendations

  • Maintain regular eye check-ups to monitor the progress of your condition.

  • Wear sunglasses to protect your eyes from sun and dust.

  • Avoid smoking as it can increase intraocular pressure.

  • Limit the intake of caffeine as it can increase eye pressure.

  • Incorporate leafy greens, fish high in omega-3 fatty acids, and non-meat protein sources like eggs, nuts, and beans in your diet. These foods are good for eye health.

Frequently asked questions

Benzalkonium Chloride + Netarsudil may cause changes in the pigmentation of the iris, eyelid skin, and eyelashes, which can be permanent.

This combination is commonly used in eye drops to reduce high intraocular pressure (IOP) in patients with glaucoma or ocular hypertension.

No, it is recommended to remove contact lenses before applying the drops because Benzalkonium Chloride can be absorbed by soft lenses. You can reinsert them after 15 minutes.

This medication is contraindicated in patients with hypersensitivity to netarsudil, benzalkonium chloride, or any of the other ingredients in the formulation.

Overdosage with Benzalkonium Chloride + Netarsudil may result in increased ocular adverse reactions. If you suspect an overdose, stop using the medication and seek medical attention immediately.

The opened bottle of this medication should be discarded 4 weeks after opening.

Patients should avoid touching the tip of the eye dropper to their eye or any other surface, as this may contaminate the solution.

Terms & Conditions


Benzalkonium Chloride + Netarsudil in other salts

BENZALKONIUM CHLORIDE + CHOLINE SALICYLATE + LIDOCAINE / LIGNOCAINEBENZALKONIUM CHLORIDE + ZINC OXIDEBENZALKONIUM CHLORIDE + BROMFENAC + MOXIFLOXACINBENZALKONIUM CHLORIDE + OFLOXACINBENZALKONIUM CHLORIDE + CYCLOPENTOLATEBENZALKONIUM CHLORIDE + CIPROFLOXACINBENZALKONIUM CHLORIDE + CIPROFLOXACIN + DEXAMETHASONEBENZALKONIUM CHLORIDE + FLUOROMETHOLONEBENZALKONIUM CHLORIDE + FLUOROMETHOLONE + TOBRAMYCINBENZALKONIUM CHLORIDE + GATIFLOXACINBENZALKONIUM CHLORIDE + DEXAMETHASONE + OFLOXACINBENZALKONIUM CHLORIDE + NEPAFENACBENZALKONIUM CHLORIDE + MOXIFLOXACIN + PREDNISOLONEBENZALKONIUM CHLORIDE + TOBRAMYCINBENZALKONIUM CHLORIDE + CHOLINE SALICYLATEBENZALKONIUM CHLORIDE + DEXAMETHASONE + TOBRAMYCINBENZALKONIUM CHLORIDE + BRIMONIDINE + TIMOLOLALCAFTADINE + BENZALKONIUM CHLORIDEBENZALKONIUM CHLORIDE + TIMOLOLBENZALKONIUM CHLORIDE + BRINZOLAMIDEBENZALKONIUM CHLORIDE + FLUCONAZOLEBENZALKONIUM CHLORIDE + KETOROLAC + MOXIFLOXACINBENZALKONIUM CHLORIDE + LATANOPROSTBENZALKONIUM CHLORIDE + OLOPATADINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + BRIMONIDINEBENZALKONIUM CHLORIDE + PHENYLEPHRINE + TROPICAMIDEBENZALKONIUM CHLORIDE + BEPOTASTINEBENZALKONIUM CHLORIDE + BRIMONIDINE + BRINZOLAMIDEBENZALKONIUM CHLORIDE + BIMATOPROSTBENZALKONIUM CHLORIDE + BIMATOPROST + TIMOLOLBENZALKONIUM CHLORIDE + BRINZOLAMIDE + TIMOLOLBENZALKONIUM CHLORIDE + CYCLOSPORINBENZALKONIUM CHLORIDE + KETOROLAC + OLOPATADINEBENZALKONIUM CHLORIDE + DORZOLAMIDEBENZALKONIUM CHLORIDE + DORZOLAMIDE + TIMOLOLBENZALKONIUM CHLORIDE + GATIFLOXACIN + PREDNISOLONEBENZALKONIUM CHLORIDE + LATANOPROST + TIMOLOLBENZALKONIUM CHLORIDE + LOTEPREDNOLBENZALKONIUM CHLORIDE + LOTEPREDNOL + TOBRAMYCINBENZALKONIUM CHLORIDE + DEXAMETHASONE + MOXIFLOXACINBENZALKONIUM CHLORIDE + LOTEPREDNOL + MOXIFLOXACINBENZALKONIUM CHLORIDE + BROMFENACBENZALKONIUM CHLORIDE + MOXIFLOXACINBENZALKONIUM CHLORIDE + OLOPATADINEBENZALKONIUM CHLORIDE + PREDNISOLONEBENZALKONIUM CHLORIDE + TIMOLOL + TRAVOPROSTBENZALKONIUM CHLORIDE + TRAVOPROSTBENZALKONIUM CHLORIDE + NATAMYCINBENZALKONIUM CHLORIDE + CAMPHOR + MENTHOL + NAPHAZOLINE HYDROCHLORIDE + PHENYLEPHRINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + GANCYCLOVIR
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