Bortezomib

Dosage Forms Available

• Bortezomib is available as a sterile lyophilized powder in single-use vials and is administered either by intravenous or subcutaneous infusion.

Age and Dose Restrictions

• Bortezomib is primarily for adults, but Bortezomib may be considered for pediatric patients with certain cancers, subject to the discretion of the treating doctor.

Contraindications

• Bortezomib is contraindicated in patients with severe hypersensitivity to Bortezomib, boron or mannitol. Caution should be exercised in patients with pre-existing severe peripheral neuropathy.

Other Medications to Avoid

• Bortezomib may interact with strong inhibitors of the CYP3A4 enzyme (e.g., ketoconazole and ritonavir) and strong inducers of the CYP3A4 enzyme (e.g., rifampin and carbamazepine).

Overdose and Missed Dose

• Overdosing on Bortezomib can result in serious adverse effects such as severe peripheral neuropathy and acute kidney injury. Consult your doctor immediately.

• If a dose is missed, it should be taken as soon as it is remembered, but not if it is almost time for the next scheduled dose. In such cases, the missed dose should be skipped and the usual dosing schedule resumed.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing Bortezomib. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Nausea and vomiting can be managed by taking the medication after meals.

• Fatigue can be managed by taking rest and maintaining adequate hydration.

Use in Driving and Operating Machinery

• Bortezomib may cause dizziness, fatigue, or other side effects that can affect your ability to drive or operate heavy machinery. Avoid such activities if you experience these symptoms.

Use in Pregnancy and Lactation

• Bortezomib is not recommended during pregnancy and lactation unless prescribed by your doctor. Consult your doctor before taking this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

• Patients with existing liver or kidney disease should exercise caution when taking Bortezomib as it may affect liver function and renal function. Caution should also be exercised in patients with existing cardiac conditions as Bortezomib may cause cardiac side effects such as heart failure and abnormal heart rhythms.

Special Dietary and Lifestyle Recommendations

• Include magnesium-rich foods like spinach, almonds and avocados to help manage potential electrolyte imbalances caused by Bortezomib.

• Focus on small, frequent, high-calorie meals to maintain energy levels, especially if experiencing reduced appetite or weight loss.