The primary use of Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium is in the management of chronic obstructive pulmonary disease (COPD) and asthma, belonging to the class of triple combination bronchodilator and corticosteroid medications.
This medication is also used in patients whose symptoms are not adequately controlled on other medications.
Headache
Nausea
Throat irritation
Muscle spasms
Dry mouth
Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium is a combination medicine used to manage chronic obstructive pulmonary disease (COPD) and asthma.
Budesonide is a corticosteroid. This means it works by lowering the activity of your body's immune response, which reduces inflammation, swelling, and excess mucus in your airways.
Formoterol Fumarate is a long-acting beta2-adrenergic receptor agonist (LABA). It functions by relaxing and opening the muscles around your airways, increasing airflow to your lungs.
Glycopyrrolate or Glycopyrronium is a long-acting muscarinic antagonist (LAMA). Similarly to Formoterol Fumarate, it works by relaxing the muscles around your airways, further improving airflow.
Doctor of Medicine
BMS, FMC, MD Resident
Dosage Forms Available
Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium is available via inhalation route, as a metered dose inhaler (MDI) and dry powder inhaler (DPI).
It can also be used as respicaps or respules, which are liquid formulations that are converted into a mist by a nebulizer for inhalation.
Age and Dose Restrictions
This combination medication is intended for use by adults and children above the age of 12 years.
Contraindications
Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium is contraindicated in patients with known allergies to any of these three active ingredients.
It is also contraindicated as the primary treatment for acute episodes of chronic obstructive pulmonary disease (COPD) and status asthmaticus.
Other Medications to Avoid
Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium may interact with strong CYP3A4 inhibitors (like ketoconazole and itraconazole), beta-blockers (like propranolol), diuretics (like furosemide), monoamine oxidase inhibitors (like phenelzine), and tricyclic antidepressants (like amitriptyline).
Always inform your doctor about all other medicines you are currently taking before starting this medication.
Overdose and Missed Dose
An overdose of this medicine may cause symptoms such as headache, nausea, fast heartbeat, tremors, and dry mouth. If you experience these symptoms, immediately inform your doctor.
If you miss a dose of this medicine, take it as soon as you remember. If it is close to the time for your next dose, then skip the missed dose and continue with your regular schedule. Do not double the dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage throat irritation or oral thrush, rinse your mouth with water after each use of the inhaler.
The risk of dry mouth can be reduced by drinking plenty of fluids throughout the day.
Avoid caffeine and alcohol as they may exacerbate some side effects such as tremors and fast heart rate.
Use in Driving and Operating Machinery
This medication may cause dizziness or blurred vision. If you experience these symptoms, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
Use of Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium during pregnancy or breastfeeding should be done only if needed and under the supervision of a doctor.
Caution in Other Conditions
Patients with cardiovascular disorders, convulsive disorders, thyrotoxicosis, diabetes, ketoacidosis should exercise caution when using Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium.
Special Dietary and Lifestyle Recommendations
Regular exercises like walking or swimming can help to improve lung capacity and overall health.
Maintaining a healthy diet rich in fruits, vegetables, lean proteins can provide essential nutrients necessary for good health.
Smoking cessation is crucial as it can worsen lung conditions.
Avoid exposure to allergens or triggers that lead to asthma attacks or COPD exacerbations.
Regular monitoring of lung function tests can help in early detection of any decline in lung function.
Frequently asked questions
Yes, Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium does contain a steroid component. Budesonide, one of the active ingredients in the combination, is a corticosteroid that helps to reduce inflammation in the airways.
While it is not common, some patients may experience mood changes as a side effect. If you notice any unusual mood changes while using the medication, it is important to discuss this with your doctor.
Yes, Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium does not contain any animal-derived components and is therefore suitable for vegetarians and vegans. However, if you have specific dietary requirements or concerns, it would be best to consult your doctor or pharmacist for more information.
There are no known natural alternatives that can provide the same therapeutic effects as this combination medication. It is designed to manage chronic obstructive pulmonary disease (COPD) and asthma by reducing inflammation and relaxing airway muscles.
If you are allergic to any of the components of Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium, you should not take this medication. Consult your doctor for alternative treatments.
Certain medications can interact with this combination and potentially cause serious side effects. Always inform your doctor of all the medications and supplements you are currently taking.
Abrupt discontinuation of this medication may lead to withdrawal symptoms or worsening of your condition. It is advised to taper off the dose gradually under your doctor's supervision.
Budesonide + Formoterol Fumarate + Glycopyrrolate / Glycopyrronium in other salts
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