Cilostazol
Uses of Cilostazol
The primary use of Cilostazol is to manage the symptoms of intermittent claudication, a condition characterised by leg pain and cramping during walking due to insufficient blood flow. Cilostazol belongs to the group of medications known as phosphodiesterase III inhibitors.
By enhancing blood flow to the extremities, it improves overall mobility and quality of life for those suffering from peripheral vascular disease. It also reduces pain, tingling, numbness, and muscle cramps in the legs, enabling patients to walk longer distances without discomfort.
Side effects of Cilostazol
Headache
Diarrhoea
Abnormal stools
Dizziness
Palpitations
How Cilostazol works
Cilostazol is a phosphodiesterase III inhibitor.
It primarily works by blocking an enzyme called phosphodiesterase III. This action prevents the breakdown of a compound called cyclic adenosine monophosphate (cAMP) in blood vessels and platelets, which leads to increased levels of cAMP. As a result, it reduces the clumping of platelets (blood cells that help clotting) and causes blood vessels to relax and widen, a process called vasodilation. In addition, Cilostazol inhibits the clumping together of platelets, which helps prevent the formation of harmful blood clots.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Cilostazol can be taken orally (tablets).
Age and Dose Restrictions
Cilostazol is primarily intended for use in adults. Children should not be given this medication unless prescribed by a doctor.
Contraindications
Cilostazol is contraindicated in patients with congestive heart failure. It is also contraindicated in patients with active bleeding disorders such as bleeding ulcers and intracranial bleeding. People with severe hepatic impairment should not take Cilostazol. Patients who are hypersensitive to Cilostazol or any of its components should avoid this medication.
Other Medications to Avoid
Cilostazol may interact with inhibitors of CYP3A4 and CYP2C19 (such as, ketoconazole and omeprazole), antiplatelet agents (like aspirin and clopidogrel), and anticoagulants (such as warfarin).
Overdose and Missed Dose
An overdose of Cilostazol can lead to serious health problems. If you accidentally take more than the recommended dose, you should immediately seek medical help.
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage headaches, rest and avoid activities that may trigger them.
For diarrhoea, drink plenty of fluids to replace lost fluids.
If you experience dizziness, sit or lie down until the symptoms pass.
Use in Driving and Operating Machinery
Cilostazol may cause dizziness or fainting in some individuals. Therefore, it is advised not to drive or operate heavy machinery if you experience these side effects while taking this medication.
Use in Pregnancy and Lactation
This medicine is not recommended during pregnancy and breastfeeding unless recommended by your doctor. Consult your doctor before using this medicine during pregnancy and breastfeeding.
Caution in Other Conditions
Patients with a history of angina, myocardial infarction, coronary interventions, or ventricular tachycardia should exercise caution while taking Cilostazol. Regular monitoring of cardiovascular and hematologic parameters is advised in these cases.
Special Dietary and Lifestyle Recommendations
Exercise regularly to improve cardiovascular health.
Make sure to keep your feet clean and moisturise to prevent dryness and cracks that can lead to complications.
Frequently asked questions
Is Cilostazol a steroid?
No, Cilostazol is not a steroid. It is a phosphodiesterase III inhibitor used to manage symptoms of intermittent claudication.
How does Cilostazol impact sleep?
Cilostazol does not typically impact sleep. However, if you are experiencing sleep disturbances, consult your doctor, as it might be due to an underlying condition or another medication you are taking.
Is Cilostazol likely to affect fertility?
Cilostazol is not directly associated with affecting fertility. However, if you have concerns about this, it is always best to consult your doctor
Is Cilostazol available over the counter or do I need a prescription?
Cilostazol is a prescription medication and is not available over the counter.
Is it safe to take Cilostazol daily?
Yes, it is safe to take Cilostazol daily as per the prescribed dosage by your doctor.
How much time does Cilostazol take to show effects?
Patients may start noticing improvements in their walking distance within 2-4 weeks of initiating therapy with Cilostazol.
What is the best time to take Cilostazol?
Cilostazol should ideally be taken at least 30 minutes before or 2 hours after meals, as per your doctor's advice.
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