Cyclosporin

Dosage Forms Available

• Cyclosporin is available for oral administration (capsules and solutions).

• It is also available as eye drops for ophthalmic use and in injection form (intravenously).

Age and Dose Restrictions

• This medicine is meant for adults and children above 2 years.

Contraindications

• Cyclosporin is contraindicated in patients with known hypersensitivity to Cyclosporin or any of its excipients.

• It is also contraindicated in patients with uncontrolled hypertension, malignancies (except non-melanoma skin cancer), and those who are using bosentan.

Other Medications to Avoid

• Cyclosporin may interact with CYP3A4 inhibitors (e.g., ketoconazole and erythromycin), CYP3A4 inducers (e.g., rifampin and carbamazepine), P-gp inhibitors (e.g., verapamil and quinidine), and nephrotoxic medicines (e.g., aminoglycosides and amphotericin B).

Overdose and Missed Dose

• Overdose of Cyclosporin can lead to symptoms like reversible renal dysfunction, hepatotoxicity, hypertension, and neurotoxicity. Immediate medical attention is required.

• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of fluids may help with side effects like dry mouth and constipation.

• Taking this medicine with meals can help reduce stomach upset.

Use in Driving and Operating Machinery

• Cyclosporin may cause drowsiness or dizziness. If this happens, do not drive or operate heavy machinery.

Use in Pregnancy and Lactation

• Cyclosporin should only be used during pregnancy if the potential benefit to the mother justifies the potential risk to the fetus. It has been found in breast milk; thus, Cyclosporin is not recommended during breastfeeding. Always consult your doctor before starting any medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

• Caution is advised when using Cyclosporin in patients with renal impairment or liver disease. Dose adjustment may be necessary for these patients.

Special Dietary and Lifestyle Recommendations

• Limit sodium intake, as this medicine may cause hypertension.

• Continue to take this medicine even if you feel well. Do not stop taking it without consulting your doctor.