Diacerein
Uses of Diacerein
Diacerein is primarily used in the management of symptomatic osteoarthritis, specifically in the knee and hip joints, and falls under the category of anthraquinone medications.
It is often prescribed as a long-term therapy to reduce pain, stiffness, and functional limitations associated with this condition.
Side effects of Diacerein
Diarrhoea
Abdominal pain
Soft stools
Urine discoloration
Skin rash
How Diacerein works
Diacerein is an anthraquinone class of medicine.
It works by inhibiting the production and activity of interleukin-1 beta (IL-1β), a key inflammatory mediator in osteoarthritis. This reduces inflammation and associated symptoms in osteoarthritis. Diacerein also reduces the sensitivity of cells to IL-1 by decreasing the number of IL-1 receptors on chondrocytes (cartilage cells).
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Diacerein is primarily available in the form of oral capsules.
Age and Dose Restrictions
Diacerein is intended for use in adults.
Contraindications
Diacerein is contraindicated in patients with hypersensitivity to diacerein or any components of the formulation. It should be avoided in individuals with severe liver or kidney disease.
Other Medications to Avoid
Diacerein may interact with diuretics (such as furosemide and hydrochlorothiazide). It should be used cautiously with cardiac glycosides (like digoxin and digitoxin).
Overdose and Missed Dose
Overdosing on Diacerein can cause an increase in the severity of side effects, particularly gastrointestinal disturbances. If you suspect an overdose, contact your doctor immediately.
If you miss a dose of Diacerein, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For mild gastrointestinal side effects such as diarrhoea or abdominal pain, consider taking the medication with meals.
Stay hydrated to help manage diarrhoea.
Ensure adequate rest to manage fatigue or dizziness.
Use in Driving and Operating Machinery
Diacerein might cause dizziness or fatigue in some individuals. If you experience such symptoms, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
Diacerein is not recommended for use during pregnancy or lactation.
Caution in Other Conditions
Individuals with liver and kidney diseases should exercise caution while using Diacerein as it might increase the risk of adverse effects. Elderly patients and individuals with inflammatory bowel diseases should also use this medication carefully.
Special Dietary and Lifestyle Recommendations
Weight control is essential as excess weight can put extra pressure on weight-bearing joints, worsening the symptoms of osteoarthritis.
Avoid activities that strain affected joints.
Frequently asked questions
How much time does It take for Diacerein to show effects?
As a symptomatic slow-acting medicine for osteoarthritis (SYSADOA), the full effects of Diacerein may take several weeks to appear.
Does Diacerein belong to the group of steroids?
No, Diacerein is not a steroid. It belongs to the class of medications known as anthraquinones.
Is a prescription required to purchase Diacerein?
Yes, a prescription from a registered medical practitioner is typically required to purchase Diacerein.
Can I take Diacerein daily?
Diacerein should be taken as per the dosage prescribed by your doctor.
What is the best time to take Diacerein?
Diacerein should be taken orally with meals as directed by your doctor.
Can Diacerein cause sleep disturbances?
There is no evidence suggesting that Diacerein directly impacts sleep patterns. However, if you experience any unusual changes, consult with your doctor.
Could Diacerein affect fertility in men or women?
No known evidence suggests that Diacerein directly affects fertility in men or women.
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