Divalproex

Dosage Forms Available

• Divalproex can be taken orally (delayed-release tablet, extended-release tablet, sprinkle capsule and capsule)

Age and Dose Restrictions

• Divalproex is indicated for use in adults and children who are 10 years of age or older.

Contraindications

• Divalproex is contraindicated in patients who have known hypersensitivity to the medicine or any of its components. It should not be used in patients with significant hepatic disease or dysfunction, or known urea cycle disorders.

Other Medications to Avoid

• Divalproex can interact with non-steroidal anti-inflammatory medicine (such as aspirin), carbapenem antibiotics (like imipenem), other antiepileptic (like lamotrigine, phenobarbital, primidone, phenytoin, and carbamazepine) and antiviral medications (like ritonavir, lopinavir, efavirenz, and rifampin).

Overdose and Missed Dose

• An overdose of Divalproex can lead to severe drowsiness, heart disturbances, low body temperature, and heavy or laboured breathing. If an overdose is suspected, immediate medical attention is required.

• If a dose of Divalproex is missed, it should be taken as soon as remembered. However, if it is near the time for the next dose, the missed dose should be skipped. Do not double the dose to catch up.

Management of Side Effects

Most side effects of Divalproex are temporary and generally resolve when discontinuing the medicine. However, if severe side effects are experienced or symptoms worsen, consult your doctor.

• Drinking plenty of water might help alleviate some gastrointestinal side effects such as nausea and indigestion.

• Ensure to get enough rest to manage dizziness or drowsiness.

Use in Driving and Operating Machinery

• Divalproex may cause dizziness, drowsiness, or blurred vision. These could affect the ability to drive or operate machinery. It is advised to avoid such activities until you know how this medication affects you.

Use in Pregnancy and Lactation

• Divalproex can cause harm to the fetus when administered to a pregnant woman. It is advised to avoid use during pregnancy unless clearly needed. Consult your doctor before using this medication while breastfeeding.

Caution in Other Conditions

• Patients with liver disease should exercise caution when taking Divalproex as it may elevate liver enzymes and cause liver injury.

• The medicine should also be used with caution in patients with mitochondrial disorders due to an increased risk of liver failure.

Special Dietary and Lifestyle Recommendations

• Regular checkups are recommended for patients who are taking Divalproex for a longer duration.

• Stress management techniques such as deep breathing, yoga, and other relaxation therapies may be beneficial as stress can exacerbate conditions like bipolar disorder and seizures.