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Glibenclamide

Uses of Glibenclamide

  • The primary use of Glibenclamide is to manage blood sugar levels in adults with type 2 diabetes. It falls under the class of oral antidiabetic medications known as sulfonylureas.

  • Though Glibenclamide is most commonly used to manage type 2 diabetes, it can also be combined with other antidiabetic agents like metformin or insulin when diet, exercise, and weight reduction alone are not sufficient to control blood glucose levels.

Side effects of Glibenclamide

  • Hypoglycaemia (low blood sugar)

  • Nausea

  • Heartburn

  • Dizziness

  • Weight gain

How Glibenclamide works

  • Glibenclamide is a second-generation sulfonylurea antidiabetic medicine.

  • It works by stimulating the pancreas to release more insulin. It does this by binding to and inhibiting ATP-sensitive potassium channels in pancreatic beta cells, which leads to the depolarization of the cell membrane and the opening of calcium channels. The influx of calcium triggers insulin release, helping to lower blood sugar levels.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage forms available

  • Glibenclamide is available for oral use in the form of tablets.

  • This medicine is taken by mouth, ensuring it is accessible and convenient for patients managing type 2 diabetes.

Age and dose restrictions

  • Glibenclamide is meant for use in adults only.

Contraindications

  • This medicine is contraindicated in patients with severe renal or hepatic impairment.

  • It is also not suitable for those with a known hypersensitivity to sulfonylureas.

Other medications to avoid

  • Glibenclamide may interact with non-selective beta-blockers (such as propranolol and nadolol), salicylates (like aspirin), sulfonamides (such as sulfamethoxazole), chloramphenicol, probenecid, coumarins (like warfarin), monoamine oxidase inhibitors (like selegiline), and antifungals (such as fluconazole).

  • Additionally, interactions may occur with thiazides, corticosteroids (like prednisone), phenytoin, thyroid products, estrogens, oral contraceptives, phenothiazines (like chlorpromazine), and sympathomimetics (such as epinephrine).

Overdose and missed dose

  • An overdose of Glibenclamide can lead to severe hypoglycemia, which might present symptoms such as confusion, trembling, excessive sweating, and even loss of consciousness. Immediate medical intervention is crucial in such cases.

  • If you miss a dose of Glibenclamide, take it as soon as you remember unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to make up for the missed one.

Management of side effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage nausea or heartburn that may occur with Glibenclamide, consider taking the medication with or after food.

  • If dizziness occurs, ensure you stand up slowly from a sitting or lying position to prevent falls.

Use in driving and operating machinery

  • Glibenclamide may cause dizziness or light-headedness in some individuals. It is advisable to avoid driving or operating heavy machinery until you know how Glibenclamide affects you.

Use in pregnancy and lactation

  • Glibenclamide is not recommended during pregnancy or while breastfeeding. Consult your doctor for safer alternatives.

Caution in other conditions

  • Caution should be exercised when using Glibenclamide in elderly patients and those who are malnourished.

  • Patients with mild to moderate renal or hepatic impairment should start on a lower dose due to the increased risk of hypoglycemia.

Special dietary and lifestyle recommendations

  • Adhering to a balanced diet rich in fibre and low in simple sugars can augment the effectiveness of Glibenclamide in managing blood glucose levels.

  • Regular physical activity can help enhance insulin sensitivity, which complements the action of Glibenclamide.

  • Monitoring carbohydrate intake is crucial; consider spacing carbohydrates evenly throughout the day to prevent spikes in blood glucose levels.

  • It may be helpful to work with a dietitian to create an eating plan that aligns with your health goals and medication regimen.

Frequently asked questions

No, Glibenclamide is not a steroid. It belongs to a class of medications known as sulfonylureas, which are used to manage type 2 diabetes.

There are no known reported effects of Glibenclamide on sleep. However, if you notice changes in your sleep patterns after starting this medicine, consult your doctor for advice.

Extensive medical studies do not suggest that Glibenclamide directly affects fertility. Seek your doctor's advice if you have concerns.

While taking Glibenclamide, it is essential to maintain a balanced diet as recommended by your doctor or dietician, particularly a diet that helps manage your blood sugar levels.

Yes, it is safe to take Glibenclamide daily as per your doctor's instructions. This medicine is generally prescribed for daily use to help manage blood sugar levels in people with type 2 diabetes.

Glibenclamide begins to lower blood glucose levels within an hour of oral administration, with peak effects seen within 2-4 hours.

Glibenclamide is usually taken with breakfast or the first main meal of the day. However, the timing can vary based on individual health conditions and the doctor's recommendations.

Terms & Conditions


Available medicines for GLIBENCLAMIDE
Gliconil Tablet 10
Gliconil Tablet 10
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Glybovin 2.5 Tablet 10
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₹4.63
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Glinil Tablet 10
Glinil Tablet 10
Cipla Ltd.
Pack of 10 Units
₹9.02
MRP ₹11.00
18.00% OFF
Glybovin 5 Tablet 10
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₹7.91
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Daonil Tablet 30
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Emcure Pharmaceuticals Ltd
Pack of 30 Units
₹43.97
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Glibamide 5 MG Tablet 10
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Lupin Ltd
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₹5.17
MRP ₹6.30
18.00% OFF
Semi Daonil Tablet 10
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₹6.05
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