The primary use of Letrozole is for the management of hormone receptor-positive or hormone receptor-unknown locally advanced or metastatic breast cancer in postmenopausal women. This medication belongs to the class of medicines known as aromatase inhibitors.
Apart from this, it is also used for the management of advanced breast cancer in postmenopausal women who have experienced disease progression following anti-estrogen therapy. Additionally, it serves as an extended adjuvant treatment for early-stage breast cancer in postmenopausal women who have already undergone 5 years of adjuvant tamoxifen therapy.
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Letrozole is an aromatase inhibitor.
It works by blocking the action of an enzyme called aromatase, which is responsible for converting androgens (a type of hormone) into oestrogens. In specific types of breast cancer, oestrogens can encourage the tumour to grow. Therefore, by reducing the production of oestrogens, Letrozole helps slow down or halt the growth of these cancer cells.
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Letrozole can be taken orally (tablet).
Letrozole is prescribed for adult women, specifically those who have reached menopause.
Letrozole is contraindicated in premenopausal women.
Patients who have known hypersensitivity to Letrozole or any of its components should not take this medicine.
Letrozole may interact with CYP2A6 inhibitors (such as methoxsalen and tranylcypromine), CYP3A4 inhibitors (like ketoconazole and ritonavir), and selective estrogen Receptor Modulators (such as tamoxifen).
In case of an overdose, symptoms such as dizziness, fatigue, nausea, and vomiting may occur. There is no specific antidote available; treatment should be symptomatic and supportive. Contact your doctor immediately if an overdose is suspected.
If you miss a dose of Letrozole, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Fatigue can be managed by taking rest breaks throughout the day.
If you experience dizziness, sit or lie down until the feeling passes.
Letrozole may cause dizziness and fatigue. If affected, patients should avoid driving or operating heavy machinery until they know how this medication affects them.
Letrozole may cause harm to an unborn baby and should not be used during pregnancy. It is also not recommended for use during breastfeeding due to potential risks to the nursing infant.
Letrozole should be used cautiously in patients who have osteoporosis or are at a high risk of developing bone fractures.
Patients with a history of thromboembolic events or cardiovascular disease should also exercise caution while taking this medicine.
Maintain a diet rich in calcium and vitamin D to support bone health, as Letrozole can potentially lead to weakening of the bones (osteoporosis).
Regular weight-bearing exercises are recommended to maintain bone strength.
Frequently asked questions
No, Letrozole tablets should not be crushed or split. If you have trouble swallowing the tablet whole, you can disperse it in water or orange juice just before taking it.
The therapeutic effects of Letrozole are typically seen within 2-3 months of starting the medicine. However, everyone is different, and the exact timing may vary. Regular follow-ups with your doctor are crucial to monitor your response to the medication.
No, Letrozole is not a steroid. It is classified as an aromatase inhibitor which is a type of non-steroidal medication used for managing certain types of breast cancer in postmenopausal women.
Occasional alcohol consumption is unlikely to interfere with the effectiveness of Letrozole. However, excessive alcohol intake may enhance some of the side effects of this medication, such as dizziness, and should be avoided.
Letrozole tablets should be stored at room temperature (15-30°C), in a tightly sealed container. Keep them away from heat, moisture, and direct light. Always keep this medication out of reach of children and pets.
Letrozole can be taken at any time of the day, but it should be taken at the same time each day for maximum effectiveness.
Yes, it is safe to take Letrozole daily as long as it is taken according to the doctor's prescribed dose and duration.
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