Metformin + Remogliflozin Etabonate + Vildagliptin

Dosage Forms Available

• Metformin + Remogliflozin Etabonate + Vildagliptin is available in the form of tablets.

• This medicine is taken orally, and the tablets should be swallowed whole with water.

Age and Dose Restrictions

• This medicine is intended for use in adults only.

• It is not recommended for use by children or adolescents under 18 years of age.

Contraindications

• Metformin + Remogliflozin Etabonate + Vildagliptin is contraindicated in patients with type 1 diabetes mellitus.

• It is also contraindicated in those experiencing diabetic ketoacidosis.

• Patients with severe renal impairment (eGFR <30 mL/min/1.73m²) should not use this medicine.

• It is contraindicated for those with a history of serious hypersensitivity reactions to any of its components.

Other Medications to Avoid

• This combination may interact with other antidiabetic agents (such as insulin, glipizide), medications affecting renal function (like furosemide), and medicines that impact glucose metabolism (like dexamethasone).

Overdose and Missed Dose

• In the event of an overdose, supportive treatment should be initiated based on the patient's clinical signs and symptoms. For Metformin overdose, hemodialysis may be required to remove accumulated medicine.

• If a dose of Metformin + Remogliflozin Etabonate + Vildagliptin is missed, it should be taken as soon as remembered, unless it is almost time for the next dose. In such cases, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage gastrointestinal upset, consider taking the medicine with food or adjusting the timing of the dose.

• Increase fluid intake to help manage minor dehydration symptoms possibly caused by remogliflozin etabonate.

Use in Driving and Operating Machinery

• This medication may affect your ability to drive or operate heavy machinery, particularly if you experience dizziness or light-headedness as a side effect. Caution is advised.

Use in Pregnancy and Lactation

• The safety of using Metformin + Remogliflozin Etabonate + Vildagliptin during pregnancy and lactation has not been established. It should be used only if clearly needed and after consulting a doctor.

Caution in Other Conditions

• Caution is advised for patients with liver impairment as metformin accumulation can occur, leading to potential lactic acidosis.

• Patients with moderate renal impairment should have their dosage adjusted accordingly.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet rich in whole grains, fruits, vegetables, lean proteins, and healthy fats to help control blood sugar levels.

• Regular physical activity can improve insulin sensitivity and help manage blood glucose levels effectively.

• Monitor blood sugar levels regularly as recommended by your doctor to ensure effective management of diabetes.

• Avoid excessive alcohol consumption as it can interfere with blood glucose control and potentially interact with metformin.

• Stay hydrated, especially when taking remogliflozin etabonate, as it increases urinary glucose excretion which can lead to dehydration.

• Manage stress through techniques such as yoga or meditation which can positively affect blood sugar levels.