Nintedanib is primarily used to manage various types of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF), chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype, and systemic sclerosis-associated interstitial lung disease (SSc-ILD). It belongs to the class of tyrosine kinase inhibitors.
Diarrhoea
Nausea
Abdominal pain
Vomiting
Decreased appetite
Nintedanib is a Tyrosine Kinase Inhibitor.
It works by obstructing the activity of certain enzymes known as tyrosine kinases. Specifically, it targets those involved in the signalling pathways of Vascular Endothelial Growth Factor Receptor (VEGFR), Fibroblast Growth Factor Receptor (FGFR), and Platelet-Derived Growth Factor Receptor (PDGFR). By inhibiting these enzymes, Nintedanib helps to reduce inflammation and scarring (also called fibrosis), and slows down the abnormal growth of blood vessels in the lungs. This action helps to slow down the progression of interstitial lung diseases.
BDS, MDS
BMS, FMC, MD Resident
Nintedanib is available in the form of capsules for oral administration.
This medicine is meant for adults.
It is not recommended for use in children as the safety and effectiveness in this age group have not been established.
Nintedanib is contraindicated in patients with known hypersensitivity to the active ingredient or any of the excipients used in the formulation.
Nintedanib may interact with P-glycoprotein (P-gp) inhibitors (such as amiodarone and verapamil) and CYP3A4 inhibitors (such as ketoconazole and ritonavir).
Overdose of Nintedanib may cause symptoms like severe diarrhoea, nausea, vomiting, or stomach pain. In case of suspected overdose, consult a doctor immediately.
If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids can help manage side effects like diarrhoea and nausea.
Eating small, frequent meals can help manage decreased appetite.
Nintedanib may cause side effects such as dizziness or blurred vision which may affect your ability to drive or operate machinery.
Nintedanib can cause harm to the fetus and is not recommended during pregnancy.
It's also not recommended during breastfeeding as it's unknown whether this medicine passes into breast milk.
Nintedanib should be used with caution in patients with liver problems as it may worsen the condition.
Its use should also be monitored closely in patients with bleeding disorders or heart problems.
Those suffering from interstitial lung disease should maintain a healthy weight as being overweight can put more stress on the lungs.
Engage in regular physical activity to keep the lungs healthy and functioning well.
Avoid exposure to pollutants and irritants that can cause further damage to the lungs.
Follow a balanced diet, rich in fruits, vegetables, and lean proteins to support overall health and well-being.
Regular follow-ups with the doctor are necessary to monitor the progression of the disease and adjust medication if needed.
Frequently asked questions
No, Nintedanib is not a steroid. It is an anti-fibrotic drug classified as a tyrosine kinase inhibitor.
The research data does not specify any impact of Nintedanib on sleep. However, individual patient experiences may vary. If any sleep disturbances are noticed while taking Nintedanib, it should be discussed with the doctor.
Nintedanib may potentially harm the foetus if given to pregnant women. Women of reproductive age are advised to use highly effective contraception during treatment and for at least 3 months after the last dose of Nintedanib.
Nintedanib should be taken as advised by your doctor. The usual recommended dosage is twice daily.
The exact time for Nintedanib to show its effect can vary between individuals and depends on the specific condition being managed.
Nintedanib should be taken orally twice daily, approximately 12 hours apart, with food, or as instructed by your doctor.
Yes, weight loss is one of the common side effects associated with Nintedanib.
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